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MCBJC(Neurogenesis/adult neural stem cell)

MCBJC(Neurogenesis/adult neural stem cell)# Biology - 生物学

M*e2003-04-07 07:04

1 楼

this Nature paper (2002 417:39) addressed the mechanisms that
control fate of neural stem cells. astrocytes have been
thought merely as supportive cells in the central nervous
system, however, this work has demonstrated that astrocytes
isolated from adult hippocampus, but not spinal chord,
promoted neurogenesis (i.e., neuron fate) of the adult neural
stem cells in cell culture. this study has highlighted the
effects of the environment on the specification of stem cells.
for stem cell research, m

m*d2003-04-07 07:04

2 楼

To study NSC differentiation, GFP and differentiation maker can be used in
vitro, which is relatively easy. In vivo differentiation
studies usually adopt 2 strategies: transplantation or retroviral injection
to trace the progenies of NSC. People have done that,
showing that different cell types are generated, but it's really hard to say
these different progenies are from the same SINGLE
ancestor. Till now, I think there is still NO convicing evidence to demostra
te NSC existence in vivo. Some p

【在 M****e 的大作中提到】

: this Nature paper (2002 417:39) addressed the mechanisms that
: control fate of neural stem cells. astrocytes have been
: thought merely as supportive cells in the central nervous
: system, however, this work has demonstrated that astrocytes
: isolated from adult hippocampus, but not spinal chord,
: promoted neurogenesis (i.e., neuron fate) of the adult neural
: stem cells in cell culture. this study has highlighted the
: effects of the environment on the specification of stem cells.
: for stem cell research, m

M*e2003-04-07 07:04

3 楼

very good points. while you have listed so many answers that
others could not participate, i have to ban you. hehe.
as for the functional analysis, i think a long-term in vivo
observation is important if the final goal is for clinics.
however, when i talked with Fred Gage, he did not seem to be
interested; one reason i think is that stem cell research is
not welcomed by the politicians and its clinical prospect is
still shaddowed. btw, there are too many unknowns, and it is
still not applicable

【在 m*******d 的大作中提到】

:
: To study NSC differentiation, GFP and differentiation maker can be used in
: vitro, which is relatively easy. In vivo differentiation
: studies usually adopt 2 strategies: transplantation or retroviral injection
: to trace the progenies of NSC. People have done that,
: showing that different cell types are generated, but it's really hard to say
: these different progenies are from the same SINGLE
: ancestor. Till now, I think there is still NO convicing evidence to demostra
: te NSC existence in vivo. Some p