Re: 说防守，不能不提罗得曼 (转载)# Joke - 肚皮舞运动
T*7
1 楼
杂志：Annals of Allergy, Asthma & Immunology
请发简历给我，谢谢。
"Genome-wide association study identifies ALLC polymorphisms associated with
FEV1 change by corticosteroid"
Article Type: Original Article
Background: Asthma is characterized by chronic airway inflammation and
remodeling, which can be suppressed by inhaled corticosteroids (ICS).
However, response to ICS shows marked inter-individual variability.
Objective: To identify the genetic variants associated with the change in
the percentage of forced expiratory volume in 1 second (%FEV1)
following ICS treatment.
Methods: A genome-wide association study of 430,487 single-nucleotide
polymorphisms (SNPs) was performed in 189 Korean asthmatic subjects. To
further investigate these genetic associations, 11 additional SNPs on the
allantoicase (ALLC) gene were selected from the HapMap database and
genotyped in the same 189 asthmatic patients in the follow-up study.
Results: In a genome-wide study, we identified the lowest P-value in ALLC on
2q35, but none of the SNPs met the genome-wide association criteria (P < 1.
0 × 10-8). However, among 25 SNPs on ALLC in the follow-up study, six
variants (rs17445240, rs13418767, rs6754459, rs17017879, rs7558370, and
rs11123610) showed significant associations with the mean %FEV1 in
the study subjects (P < 3.73 × 10-6).
Conclusion: Although the associated signals could not overcome the genome-
wide multiple correction due to small sample size, our results suggest that
associated SNPs of ALLC might be genetic predictors of response to ICS, at
least with respect to %FEV1 in Korean asthmatics.
请发简历给我，谢谢。
"Genome-wide association study identifies ALLC polymorphisms associated with
FEV1 change by corticosteroid"
Article Type: Original Article
Background: Asthma is characterized by chronic airway inflammation and
remodeling, which can be suppressed by inhaled corticosteroids (ICS).
However, response to ICS shows marked inter-individual variability.
Objective: To identify the genetic variants associated with the change in
the percentage of forced expiratory volume in 1 second (%
following ICS treatment.
Methods: A genome-wide association study of 430,487 single-nucleotide
polymorphisms (SNPs) was performed in 189 Korean asthmatic subjects. To
further investigate these genetic associations, 11 additional SNPs on the
allantoicase (ALLC) gene were selected from the HapMap database and
genotyped in the same 189 asthmatic patients in the follow-up study.
Results: In a genome-wide study, we identified the lowest P-value in ALLC on
2q35, but none of the SNPs met the genome-wide association criteria (P < 1.
0 × 10-8). However, among 25 SNPs on ALLC in the follow-up study, six
variants (rs17445240, rs13418767, rs6754459, rs17017879, rs7558370, and
rs11123610) showed significant associations with the mean %
the study subjects (P < 3.73 × 10-6).
Conclusion: Although the associated signals could not overcome the genome-
wide multiple correction due to small sample size, our results suggest that
associated SNPs of ALLC might be genetic predictors of response to ICS, at
least with respect to %
