糖尿病孕妇如何选择降糖药？# NextGeneration - 我爱宝宝
m*8
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请教糖尿病孕妇如何选择降糖药？
这边的医生说glyburide或insulin在疗效上和安全性上没什么差别。可查了国内的医学
资料，glyburide禁忌用于孕妇。再上网查了英文资料，发现FDA没有足够证据证明
glyburide用于孕妇是安全的（归于C类），动物实验表明该药有危害性。
难道这边医生的说法有误？
（Glyburide has been assigned to pregnancy category C by the FDA. Animal
studies have revealed evidence of fetal toxicity. Other sulfonylureas have
been associated with an increased teratogenic risk in animal studies. There
are no controlled data in human pregnancy. The use of oral sulfonylureas
during pregnancy has been reported to result in neonatal hypoglycemia.
Insulin remains the mainstay of therapy for gestational diabetes due to the
close glucose control it affords. The manufacturer states that glyburide
should not be used during pregnancy. Glyburide is generally considered
contraindicated during pregnancy and is only recommend for use during
pregnancy when there are no alternatives and benefit outweighs risk. http://www.drugs.com/pregnancy/glyburide.html）。
这边的医生说glyburide或insulin在疗效上和安全性上没什么差别。可查了国内的医学
资料，glyburide禁忌用于孕妇。再上网查了英文资料，发现FDA没有足够证据证明
glyburide用于孕妇是安全的（归于C类），动物实验表明该药有危害性。
难道这边医生的说法有误？
（Glyburide has been assigned to pregnancy category C by the FDA. Animal
studies have revealed evidence of fetal toxicity. Other sulfonylureas have
been associated with an increased teratogenic risk in animal studies. There
are no controlled data in human pregnancy. The use of oral sulfonylureas
during pregnancy has been reported to result in neonatal hypoglycemia.
Insulin remains the mainstay of therapy for gestational diabetes due to the
close glucose control it affords. The manufacturer states that glyburide
should not be used during pregnancy. Glyburide is generally considered
contraindicated during pregnancy and is only recommend for use during
pregnancy when there are no alternatives and benefit outweighs risk. http://www.drugs.com/pregnancy/glyburide.html）。
