k*4
2 楼
臭虫，蜈蚣，老鼠， 人粪尿
【在 m******u 的大作中提到】
: eat right. what's the right thingies to eat?
【在 m******u 的大作中提到】
: eat right. what's the right thingies to eat?
l*r
3 楼
Eat more veggie, fruits, fish/shell, less fatty meat. Walk after dinner
helps.
【在 m******u 的大作中提到】
: eat right. what's the right thingies to eat?
helps.
【在 m******u 的大作中提到】
: eat right. what's the right thingies to eat?
N*2
4 楼
跑步最有效。不过你一停可能很快就会去了。
【在 m******u 的大作中提到】
: eat right. what's the right thingies to eat?
【在 m******u 的大作中提到】
: eat right. what's the right thingies to eat?
c*9
5 楼
all in with margin for six month.
no more chlosterl
no more chlosterl
h*s
6 楼
mayoutu's egg?
【在 m******u 的大作中提到】
: eat right. what's the right thingies to eat?
【在 m******u 的大作中提到】
: eat right. what's the right thingies to eat?
C*1
7 楼
酵母中有植物类胆固醇，能降低胆固醇的吸收，所以可以吃些馒头之类的，或者直接吃
酵母粉。
少吃蛋黄，动物内脏，他们都富含胆固醇。
酵母粉。
少吃蛋黄，动物内脏，他们都富含胆固醇。
E*r
8 楼
I think I am probably the best person to answer this question as one of my
projects at San Francisco General Hospital is to differentiate cholesterol
imbalance. There are two major routes for cholesterol accumulation in the
body.
The first one is through in vivo biosynthesis via a key enzyme called HMGCoA
reductase. Therefore, in order to lower cholesterol based on de novo
systhesis, a drug family called statins, is widely used because it inhibits
this key enzyme. Nowadays, measuring the concentration of a biomarker called
Lathosterol is indicative of high cholesterol derived from this pathway due
to its identity as an intermediate in the process.
The second route is through small intestine absorption from diet. That is
to say, high cholesterol via this channel means eating too much. Certainly
, reducing food consumption is one way out. However, more people consider
taking a drug called ereztimibe,which inhibits the conversion from
substrates to cholesterol. Campesterol and sistosterol are two best markers
to reflect diet related cholesterol escalation.
We are going to launching an assay which can easily guide doctors through
the best treatment. This can be a lucrative business as everyone over 45
needs to be tested at least twice a year.
projects at San Francisco General Hospital is to differentiate cholesterol
imbalance. There are two major routes for cholesterol accumulation in the
body.
The first one is through in vivo biosynthesis via a key enzyme called HMGCoA
reductase. Therefore, in order to lower cholesterol based on de novo
systhesis, a drug family called statins, is widely used because it inhibits
this key enzyme. Nowadays, measuring the concentration of a biomarker called
Lathosterol is indicative of high cholesterol derived from this pathway due
to its identity as an intermediate in the process.
The second route is through small intestine absorption from diet. That is
to say, high cholesterol via this channel means eating too much. Certainly
, reducing food consumption is one way out. However, more people consider
taking a drug called ereztimibe,which inhibits the conversion from
substrates to cholesterol. Campesterol and sistosterol are two best markers
to reflect diet related cholesterol escalation.
We are going to launching an assay which can easily guide doctors through
the best treatment. This can be a lucrative business as everyone over 45
needs to be tested at least twice a year.
H*D
9 楼
zan!
my
HMGCoA
due
synthesis.
【在 E*********r 的大作中提到】
: I think I am probably the best person to answer this question as one of my
: projects at San Francisco General Hospital is to differentiate cholesterol
: imbalance. There are two major routes for cholesterol accumulation in the
: body.
: The first one is through in vivo biosynthesis via a key enzyme called HMGCoA
: reductase. Therefore, in order to lower cholesterol based on de novo
: systhesis, a drug family called statins, is widely used because it inhibits
: this key enzyme. Nowadays, measuring the concentration of a biomarker called
: Lathosterol is indicative of high cholesterol derived from this pathway due
: to its identity as an intermediate in the process.
my
HMGCoA
due
synthesis.
【在 E*********r 的大作中提到】
: I think I am probably the best person to answer this question as one of my
: projects at San Francisco General Hospital is to differentiate cholesterol
: imbalance. There are two major routes for cholesterol accumulation in the
: body.
: The first one is through in vivo biosynthesis via a key enzyme called HMGCoA
: reductase. Therefore, in order to lower cholesterol based on de novo
: systhesis, a drug family called statins, is widely used because it inhibits
: this key enzyme. Nowadays, measuring the concentration of a biomarker called
: Lathosterol is indicative of high cholesterol derived from this pathway due
: to its identity as an intermediate in the process.
m*u
10 楼
thanks, E牛。
E*r
11 楼
You may also check the website of Boston Heart Diagnostics. They are the
first company launching a test to differentiate high cholesterol. This test
is called cholesterol balance test. The charge is $120.
If possible, you can send your blood to this company and have them measure
several steroids. That way, doctors may know which medication is the best
for you. We will be their major competitor very soon so I cannot tell too
much about what we are going to do.
first company launching a test to differentiate high cholesterol. This test
is called cholesterol balance test. The charge is $120.
If possible, you can send your blood to this company and have them measure
several steroids. That way, doctors may know which medication is the best
for you. We will be their major competitor very soon so I cannot tell too
much about what we are going to do.
l*u
12 楼
看来大牛是专家，请解惑，多谢。
纯属好奇，看到有朋友为了降低胆固醇、血脂，刻意不吃某类东西，这样会不会造成机
体补偿性代谢导致更严重的后果？就比如代糖的副作用。
HMGCoA
inhibits
called
due
【在 E*********r 的大作中提到】
: I think I am probably the best person to answer this question as one of my
: projects at San Francisco General Hospital is to differentiate cholesterol
: imbalance. There are two major routes for cholesterol accumulation in the
: body.
: The first one is through in vivo biosynthesis via a key enzyme called HMGCoA
: reductase. Therefore, in order to lower cholesterol based on de novo
: systhesis, a drug family called statins, is widely used because it inhibits
: this key enzyme. Nowadays, measuring the concentration of a biomarker called
: Lathosterol is indicative of high cholesterol derived from this pathway due
: to its identity as an intermediate in the process.
纯属好奇，看到有朋友为了降低胆固醇、血脂，刻意不吃某类东西，这样会不会造成机
体补偿性代谢导致更严重的后果？就比如代糖的副作用。
HMGCoA
inhibits
called
due
【在 E*********r 的大作中提到】
: I think I am probably the best person to answer this question as one of my
: projects at San Francisco General Hospital is to differentiate cholesterol
: imbalance. There are two major routes for cholesterol accumulation in the
: body.
: The first one is through in vivo biosynthesis via a key enzyme called HMGCoA
: reductase. Therefore, in order to lower cholesterol based on de novo
: systhesis, a drug family called statins, is widely used because it inhibits
: this key enzyme. Nowadays, measuring the concentration of a biomarker called
: Lathosterol is indicative of high cholesterol derived from this pathway due
: to its identity as an intermediate in the process.
l*u
13 楼
嗯，这个可行：）。
【在 c*******9 的大作中提到】
: all in with margin for six month.
: no more chlosterl
【在 c*******9 的大作中提到】
: all in with margin for six month.
: no more chlosterl
l*o
14 楼
mark。
【在 m******u 的大作中提到】
: eat right. what's the right thingies to eat?
【在 m******u 的大作中提到】
: eat right. what's the right thingies to eat?
E*r
15 楼
您好！ 首先我不是专家，我是搞疾病早期诊断和预防，目前偏重于个体化医疗。我
刚才提到的是在胆固醇偏高的患者中分两类，一类是内源性，即先天性胆固醇合成过高
，这和病人体内HMGCR这个酶活性高有关。HMGCR在胆固醇合成中是一个非常关键的酶。
因此这种病人即便吃东西很注意，或者体型也偏瘦，但是胆固醇还是高。如果是这样的
话，你的朋友虽然刻意去避免吃某些可能含胆固醇高的食品，胆固醇还是不会下降，因
为本身体内产的就多。这种病人在临床上是要服用他丁Statins类药物。 第二类是外源
性，即小肠吸收胆固醇能力太强，这种病人可以通过饮食调控降低胆固醇，但是如果要
饱口福的话，可以采用Ereztimibe这个药物，它可以降低食品中一些物质转化成胆固醇
的能力。
从您谈到的情况，想知道您的朋友是刻意不吃哪种类型的东西，如果是人体必需的
，譬如像某些氨基酸，那么他/她会出现一些疾病。因为有些必要元素会激活体内的一
些酶，这些酶如果不工作，或者不100%工作的话，就会出现疾病。
我们这边马上要推出一个胆固醇平衡的测试，结果可以告知医生对病人应该以哪种
方式进行治疗，所谓的个体化医疗方案。这是一个比较热门的发展方向。李嘉诚去年就
投资给我们医院所属的UCSF 200万美元进行Precision Medicine的研究，看来老李也觉
得这是个很有前途的方向。
【在 l*****u 的大作中提到】
: 看来大牛是专家，请解惑，多谢。
: 纯属好奇，看到有朋友为了降低胆固醇、血脂，刻意不吃某类东西，这样会不会造成机
: 体补偿性代谢导致更严重的后果？就比如代糖的副作用。
:
: HMGCoA
: inhibits
: called
: due
l*u
16 楼
非常感谢您的热心回复。
朋友不吃红肉，鸡蛋，牛奶，但是吃海鲜。然后吃了处方鱼油据说效果不错。
【在 E*********r 的大作中提到】
:
: 您好！ 首先我不是专家，我是搞疾病早期诊断和预防，目前偏重于个体化医疗。我
: 刚才提到的是在胆固醇偏高的患者中分两类，一类是内源性，即先天性胆固醇合成过高
: ，这和病人体内HMGCR这个酶活性高有关。HMGCR在胆固醇合成中是一个非常关键的酶。
: 因此这种病人即便吃东西很注意，或者体型也偏瘦，但是胆固醇还是高。如果是这样的
: 话，你的朋友虽然刻意去避免吃某些可能含胆固醇高的食品，胆固醇还是不会下降，因
: 为本身体内产的就多。这种病人在临床上是要服用他丁Statins类药物。 第二类是外源
: 性，即小肠吸收胆固醇能力太强，这种病人可以通过饮食调控降低胆固醇，但是如果要
: 饱口福的话，可以采用Ereztimibe这个药物，它可以降低食品中一些物质转化成胆固醇
: 的能力。
朋友不吃红肉，鸡蛋，牛奶，但是吃海鲜。然后吃了处方鱼油据说效果不错。
【在 E*********r 的大作中提到】
:
: 您好！ 首先我不是专家，我是搞疾病早期诊断和预防，目前偏重于个体化医疗。我
: 刚才提到的是在胆固醇偏高的患者中分两类，一类是内源性，即先天性胆固醇合成过高
: ，这和病人体内HMGCR这个酶活性高有关。HMGCR在胆固醇合成中是一个非常关键的酶。
: 因此这种病人即便吃东西很注意，或者体型也偏瘦，但是胆固醇还是高。如果是这样的
: 话，你的朋友虽然刻意去避免吃某些可能含胆固醇高的食品，胆固醇还是不会下降，因
: 为本身体内产的就多。这种病人在临床上是要服用他丁Statins类药物。 第二类是外源
: 性，即小肠吸收胆固醇能力太强，这种病人可以通过饮食调控降低胆固醇，但是如果要
: 饱口福的话，可以采用Ereztimibe这个药物，它可以降低食品中一些物质转化成胆固醇
: 的能力。
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