Re: MCBJC, cell division (more discussion, 我又来乐)# Biology - 生物学
M*e
1 楼
to
i think it requires knowledge about the structure of separase. if
intermolecular, there should be protein-protein interaction, and mutations
that inhibit the interaction should abolish the cleavage, otherwise, not. i do
not know how those genius found out the intramolecular cleavage in ribozymes,
yet i think that sequence-specific mutations help to distinguish "inter" from
"intra" activation. for "intra", the problem is to find how the cleavage
occurs, there should be significant conformation
i think it requires knowledge about the structure of separase. if
intermolecular, there should be protein-protein interaction, and mutations
that inhibit the interaction should abolish the cleavage, otherwise, not. i do
not know how those genius found out the intramolecular cleavage in ribozymes,
yet i think that sequence-specific mutations help to distinguish "inter" from
"intra" activation. for "intra", the problem is to find how the cleavage
occurs, there should be significant conformation