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MCBC journal club paper (the 3rd?)

MCBC journal club paper (the 3rd?)# Biology - 生物学

b*t2003-02-04 08:02

1 楼

BBS一直不通，所以我都快一个礼拜没上来了。今天一看，斑竹已经发信给我要求present
a paper，而且deadline就是今天。虽然晚上了，但我还是met the deadline了吧？
我picked的paper如下：(没有access的请给我来信。）
Nf1 has an essential role in endothelial cells.
Gitler AD, Zhu Y, Ismat FA, Lu MM, Yamauchi Y, Parada LF, Epstein JA.
Nat Genet 2003 Jan;33(1):75-9
very nice genetics experiments. it came out as a big surprise that NF1 played
an essential role in endothelium cells themselves, as it had been thought
previously that it was the neural crest that resulted in the heart d

g*n2003-02-04 08:02

2 楼

1. It's a promising method for pathological study of diseases or development
with multi-tissue-specific gene knockout/in technique.
2. In Fig.2L, it showed thinned myocardium in nf1(nc),but not in the
tissue-specific inactivation of nf1 in myocadial cell(not shown), which
suggests nf1 is necessary for myocardium development, but not after some time
point. How about at earlier period of development than this point? So, i
think it's not cautious to conclude that nf1 function in the neural crest i

【在 b*********t 的大作中提到】

: BBS一直不通，所以我都快一个礼拜没上来了。今天一看，斑竹已经发信给我要求present
: a paper，而且deadline就是今天。虽然晚上了，但我还是met the deadline了吧？
: 我picked的paper如下：(没有access的请给我来信。）
: Nf1 has an essential role in endothelial cells.
: Gitler AD, Zhu Y, Ismat FA, Lu MM, Yamauchi Y, Parada LF, Epstein JA.
: Nat Genet 2003 Jan;33(1):75-9
: very nice genetics experiments. it came out as a big surprise that NF1 played
: an essential role in endothelium cells themselves, as it had been thought
: previously that it was the neural crest that resulted in the heart d