Second Paper - 未名空间MITBBS历史存档

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Second Paper

Second Paper# Biology - 生物学

d*r2003-10-25 07:10

1 楼

HI, all,
I eventually find a second paper for our random journal club. I first
randomly pick a letter from S, N, C and P, representing Science, Nature, Cell
and PNAS. I got C. Then I choose a month. It is 04/2003. There are two issues
in that month. I use a coin to pick one. It is the 04/18 issue. I go to its
preview. There are four of them. I randomly choose one. It is the second one,
named as: Global Phage Diversity (Cell, Vol 113, 141, 18 April 2003).
Here is the citation and summary of that

d*r2003-10-25 07:10

2 楼

This is an interesting paper because it elucidated how much information the
comparative genomics can tell us. In this paper, the authors discovered ten
new mycobacteriaphages, sequenced their genome and compared their genomes with
each other. The conclusion is revealing.
1) It shows the mycobacteriaphage genomes are highly mosaic, which means in
some part of the genome the sequence is homologous, while in other area, it is
not. This result shows there is significant horizontal gene transfer am

d*r2003-10-25 07:10

3 楼

Mycobacteriaphage (EM) image
alpha3 bacteriaphage (structure determined by X-ray and cryo-EM)
Look at the figure above, the tail of the phage is kind of fibular protein,
not globular as most proteins do.
If you look at the genome of bacteriaphage, you will find most recombination
events are outside the gene boundary. The explaination is that any
recombination within a gene will result in defective protein. This obviously
will lead to the elimination of the phages that carries this recomination
e