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reliability of academic research data
avatar
S*e
2
以前做助演的时候每次出场气场都那么强大
怎么演怎么有
感觉就是很大的腕
可是一当主演,演的是嘛呀,我看了3分钟就说得被淘汰
结果以前当助演的时候能上10次场
当了主演就露了两次面,不知道以后有没有复活机会
据说是杨幂同学
而且很早就上过春晚
本身素质不错,肯定也有人在背后推
就是怎么也红不了
所以说能不能红能不能发财主要看命
avatar
d*3
3
Just heard a lecture from Dr. Janet Woodcock, Director, Center for Drug
Evaluation and Research. One thing she mentioned was interesting. It
sounded like that FDA was challenging NIH on the reliability of academic
research data. A huge amount of money was wasted because many researches on
drug development in industry were misled by unreliable data from academic
research groups. NIH fought back calling FDA's lack of scientific awareness.
I wonder who is going to win at the end at Congress, the money keeper.
http://www.nova.edu/ssss/QR/QR8-4/golafshani.pdf
avatar
d*p
4
有什么可急得?
eb2c肯定是u
eb3c应该会前进一两个月,即使这个月前进很少,下个月也会大前进
avatar
l*o
5
我一直觉得张小斐不适合演喜剧。
不好笑。
不过混的也挺好了吧,都是没黑点艺人要上春晚的了。
常远这次感觉来的有点晚,团队似乎也没有前两季给力。
话说张小斐不是贾玲在推吗?

【在 S****e 的大作中提到】
: 以前做助演的时候每次出场气场都那么强大
: 怎么演怎么有
: 感觉就是很大的腕
: 可是一当主演,演的是嘛呀,我看了3分钟就说得被淘汰
: 结果以前当助演的时候能上10次场
: 当了主演就露了两次面,不知道以后有没有复活机会
: 据说是杨幂同学
: 而且很早就上过春晚
: 本身素质不错,肯定也有人在背后推
: 就是怎么也红不了

avatar
a*g
6
it has been a widely accepted in industry that <30% academic research are
reproducible.
not surprising that FDA is taking a stand
avatar
l*i
7
关心的 是 1类啊
白鸡五凤丸
avatar
h*w
8
他们那个团队,在编剧水平上还是差开心麻花很多的.另外她长的好看,做助演突出主演
是优势,自己主演就变成劣势了,长的好看基本观众就看脸,没什么笑点了.中国演喜剧水
平高的能担当主演的,基本没长的好看的(无论男女),典型的就是朱时茂,大概是最佳拍
档(助演),但是离开陈佩斯就不灵
以前看过采访马丽(我最喜欢的喜剧女演员),她说刚开始演喜剧和小品也是受困长相(她
也算演喜剧里面长的不错的了),后来她发明了那种招牌低音狂笑才把观众的注意力给转
过来.
贾玲原来长的其实相当不错的,后来故意吃成个胖子才红,而且她的小品基本100%都是用
这个胖子的优势观众才能笑.
avatar
O*e
10
一类不用操心。
avatar
l*o
11

对呀,昨天看youtube下面评论一水的说张小斐长的好看。。。。
张小斐跟现在的贾玲比起来是好看,但是这是喜剧舞台。
并不是说卖丑才好笑,但是除了好看也确实需要有点个人特色做卖点才能让观众笑吧。
宋丹丹其实非常好看,但是宋丹丹这么多年演小品哪里是靠脸的?
不是农村小媳妇就是脸涂的一码黑的干瘪老太太。。
如果不是喜剧舞台,只是作为演员,张小斐长相也就不突出了。
她出来的这么快,还是喜剧女星少。。
张小斐是一个,还有爱情公寓2里面那个雨墨,长得很好看,但是我也觉得不适合演喜
剧,看着就没笑点。

【在 h*****w 的大作中提到】
: 他们那个团队,在编剧水平上还是差开心麻花很多的.另外她长的好看,做助演突出主演
: 是优势,自己主演就变成劣势了,长的好看基本观众就看脸,没什么笑点了.中国演喜剧水
: 平高的能担当主演的,基本没长的好看的(无论男女),典型的就是朱时茂,大概是最佳拍
: 档(助演),但是离开陈佩斯就不灵
: 以前看过采访马丽(我最喜欢的喜剧女演员),她说刚开始演喜剧和小品也是受困长相(她
: 也算演喜剧里面长的不错的了),后来她发明了那种招牌低音狂笑才把观众的注意力给转
: 过来.
: 贾玲原来长的其实相当不错的,后来故意吃成个胖子才红,而且她的小品基本100%都是用
: 这个胖子的优势观众才能笑.

avatar
l*b
12
The other way to look at this is that the industry researchers are not
competent. Some experiments are indeed technically challenging so not many
people can successfully perform the experiments, especially when the authors
purposely don't mention detail procedures in the paper.
Having said that, when something as easy as throwing a reagent and measuring
cell cycle changes cannot be reproduced (this has happened quite a few
times), those studies become highly skeptical.
My ideal but unpractical way of solving this is, money should not be
involved in science, meaning that papers and funding are not related to the
researchers' income. That way science will be pure.
avatar
l*i
13
1类操心啊. 否则也不会难产的.

【在 O*********e 的大作中提到】
: 一类不用操心。
avatar
I*s
14
百度了一下张小斐,86年的,将来还有时间发展的。之前演了一堆正剧,战争剧之类的
,她长相也没好到能演偶像剧,不过演喜剧是绰绰有余的啦。
为啥喜剧人都要长得寒蝉的呢?
avatar
d*3
15
Maybe you are right. That's exactly what NIH said to FDA. However, if the
academic research can only enjoy itself and cannot be used to help people,
why should we fund it?

authors
measuring
the

【在 l****b 的大作中提到】
: The other way to look at this is that the industry researchers are not
: competent. Some experiments are indeed technically challenging so not many
: people can successfully perform the experiments, especially when the authors
: purposely don't mention detail procedures in the paper.
: Having said that, when something as easy as throwing a reagent and measuring
: cell cycle changes cannot be reproduced (this has happened quite a few
: times), those studies become highly skeptical.
: My ideal but unpractical way of solving this is, money should not be
: involved in science, meaning that papers and funding are not related to the
: researchers' income. That way science will be pure.

avatar
m*l
16
有了

【在 h*********f 的大作中提到】
: 娘的
avatar
f*s
17
还没看新的,但是之前的都看过,确实对她印象很好,觉得是很好的演员。不过也是她
就是配角的命,做主演颜值还是差些。
avatar
l*b
18
when we observe and study galaxy, how much are we helping people? same thing
when we study the development of wings and eyes in flies, or life span in c
elegans, are we really putting our science into application? my answer is
that we don't know yet the potential of these studies. might be huge in one
day, or might be nothing. Either way is fine, as long as the results are
solid.
The key issue here is, whether academic science is manipulated (or using a
less aggression expression, cherry-picked) to fatten some
researchers' wallet? If so, then we are wasting money. If not, I can't
speak for everyone but at least I am OK with it.

【在 d***3 的大作中提到】
: Maybe you are right. That's exactly what NIH said to FDA. However, if the
: academic research can only enjoy itself and cannot be used to help people,
: why should we fund it?
:
: authors
: measuring
: the

avatar
h*y
19
快去买个验孕纸试一试,如果一直没来估计有了。

【在 h*********f 的大作中提到】
: 娘的
avatar
g*e
20
喜剧太难了。难得有一个好的本子。

【在 S****e 的大作中提到】
: 以前做助演的时候每次出场气场都那么强大
: 怎么演怎么有
: 感觉就是很大的腕
: 可是一当主演,演的是嘛呀,我看了3分钟就说得被淘汰
: 结果以前当助演的时候能上10次场
: 当了主演就露了两次面,不知道以后有没有复活机会
: 据说是杨幂同学
: 而且很早就上过春晚
: 本身素质不错,肯定也有人在背后推
: 就是怎么也红不了

avatar
d*3
21
I don't want to start a fight because I basically agree with you. Regarding
the examples you listed, I do think they are helping people. Those are
different from publishing some results that no one else can reproduce. If
someone claims that he is the only person in the whole world who can produce
that result, then he is not helping people. One thing is clear. Any result
published by industry has to be repeatable. Otherwise, the products of that
company won't have any credit.

thing
c
one

【在 l****b 的大作中提到】
: when we observe and study galaxy, how much are we helping people? same thing
: when we study the development of wings and eyes in flies, or life span in c
: elegans, are we really putting our science into application? my answer is
: that we don't know yet the potential of these studies. might be huge in one
: day, or might be nothing. Either way is fine, as long as the results are
: solid.
: The key issue here is, whether academic science is manipulated (or using a
: less aggression expression, cherry-picked) to fatten some
: researchers' wallet? If so, then we are wasting money. If not, I can't
: speak for everyone but at least I am OK with it.

avatar
o*n
22
这个准吗

【在 h****y 的大作中提到】
: 快去买个验孕纸试一试,如果一直没来估计有了。
avatar
g*e
23
张小斐当时在第一期出来时很惊艳

【在 S****e 的大作中提到】
: 以前做助演的时候每次出场气场都那么强大
: 怎么演怎么有
: 感觉就是很大的腕
: 可是一当主演,演的是嘛呀,我看了3分钟就说得被淘汰
: 结果以前当助演的时候能上10次场
: 当了主演就露了两次面,不知道以后有没有复活机会
: 据说是杨幂同学
: 而且很早就上过春晚
: 本身素质不错,肯定也有人在背后推
: 就是怎么也红不了

avatar
l*b
24
No offense taken. We are simply discussing. :-)

Regarding
produce
result
that

【在 d***3 的大作中提到】
: I don't want to start a fight because I basically agree with you. Regarding
: the examples you listed, I do think they are helping people. Those are
: different from publishing some results that no one else can reproduce. If
: someone claims that he is the only person in the whole world who can produce
: that result, then he is not helping people. One thing is clear. Any result
: published by industry has to be repeatable. Otherwise, the products of that
: company won't have any credit.
:
: thing
: c

avatar
p*8
25
God Bless! 04/08!
avatar
I*s
26
对,印象深刻。

【在 g*******e 的大作中提到】
: 张小斐当时在第一期出来时很惊艳
avatar
b*k
27
我觉得直接造假(包括cherry picking),和故意把实验条件隐藏,和实验条件过于复
杂以至于没人能重复,其实后果都是一样的:那就是得出的结论没有用,因为别人一是
不知道真假,二是想知道真假也不知道怎么去验证。
所以如果工业界大范围的不能重复学术界的研究成果,不管是不是有什么客观原因,学
术界的这些成果不管对于推动知识进步还是解决国计民生都是没有用处的。
当然三种情形反映的人品问题的程度不一样。

thing
c
one

【在 l****b 的大作中提到】
: when we observe and study galaxy, how much are we helping people? same thing
: when we study the development of wings and eyes in flies, or life span in c
: elegans, are we really putting our science into application? my answer is
: that we don't know yet the potential of these studies. might be huge in one
: day, or might be nothing. Either way is fine, as long as the results are
: solid.
: The key issue here is, whether academic science is manipulated (or using a
: less aggression expression, cherry-picked) to fatten some
: researchers' wallet? If so, then we are wasting money. If not, I can't
: speak for everyone but at least I am OK with it.

avatar
g*s
28
弱问哪儿查VB啊?
avatar
s*e
29
造假的都应该tjjtds。
看过一个国内的非常大医院的头头发的文章,连cancer cell proliferation (MTT
assay) 的数据我都没有办法重复,给他写信,没有回音;给他的美国薄厚老板写信,
他的美国薄厚老板给他写信,还是没有回音。这种人就是垃圾。
avatar
q*i
30
小妹妹,不用弱问,知道啥叫谷歌吗?知道在美国谷歌叫google吗?
知道VB是啥的简写吗?
都知道的话,就不要用弱问来撒娇了,好不好呢?

【在 g*****s 的大作中提到】
: 弱问哪儿查VB啊?
avatar
y*3
31
科研市场化的必经之路吧。只能靠完善管理制度来慢慢改进。
avatar
g*s
32
额 小妹妹有用尼格做头像的吗

【在 q****i 的大作中提到】
: 小妹妹,不用弱问,知道啥叫谷歌吗?知道在美国谷歌叫google吗?
: 知道VB是啥的简写吗?
: 都知道的话,就不要用弱问来撒娇了,好不好呢?

avatar
p*s
33
今天听国内同学说的好玩的事情,国内某大城市研究所的研究,RT-PCR是用粉条做的..

【在 s**********e 的大作中提到】
: 造假的都应该tjjtds。
: 看过一个国内的非常大医院的头头发的文章,连cancer cell proliferation (MTT
: assay) 的数据我都没有办法重复,给他写信,没有回音;给他的美国薄厚老板写信,
: 他的美国薄厚老板给他写信,还是没有回音。这种人就是垃圾。

avatar
g*s
34
额 小妹妹有用尼格做头像的吗

【在 q****i 的大作中提到】
: 小妹妹,不用弱问,知道啥叫谷歌吗?知道在美国谷歌叫google吗?
: 知道VB是啥的简写吗?
: 都知道的话,就不要用弱问来撒娇了,好不好呢?

avatar
a*h
35
Nature 也有行动了。。那句:“ and may consult with statisticians on certain
papers.”很耳熟啊。
One Step, One Checklist at a Time
April 26, 2013
Nature Publishing Group has announced a new initiative aimed at improving
the reproducibility of research published in articles appearing across its
spectrum of journals.
To help with the issue of reproducibility, the publishing company says in a
press release it has developed a checklist to help researchers report the
details of their methodologies. The checklist "focuses on a small number of
often-incompletely reported elements of experimental and analytical design
that are crucial to the interpretation of research results; it also
consolidates several existing policies about data deposition and
presentation," the statement adds.
Nature adds that it will also be changing some of its in-house practices,
eliminating length restrictions on methods sections, and may consult with
statisticians on certain papers.
It notes in an editorial, though, that this is but a "small step" toward
solving the issue of reproducibility. "Tackling these issues is a long-term
endeavour that will require the commitment of funders, institutions,
researchers and publishers. …. We urge others to take note of these and of
our initiatives, and do whatever they can to improve research
reproducibility," the editorial adds.
avatar
r*t
37
没看明白
什么叫粉条做的RT-PCR?

..

【在 p****s 的大作中提到】
: 今天听国内同学说的好玩的事情,国内某大城市研究所的研究,RT-PCR是用粉条做的..
avatar
f*e
38
韩国造假王黄禹锡在被踢爆前讲的也是这样。这种细活只有我们韩国人能干。
科学要纯净,要和铜臭味划清界线?那绝大多数的科学家都得去喝西北风。

authors
measuring
the

【在 l****b 的大作中提到】
: The other way to look at this is that the industry researchers are not
: competent. Some experiments are indeed technically challenging so not many
: people can successfully perform the experiments, especially when the authors
: purposely don't mention detail procedures in the paper.
: Having said that, when something as easy as throwing a reagent and measuring
: cell cycle changes cannot be reproduced (this has happened quite a few
: times), those studies become highly skeptical.
: My ideal but unpractical way of solving this is, money should not be
: involved in science, meaning that papers and funding are not related to the
: researchers' income. That way science will be pure.

avatar
l*s
39
probably he means to use 粉条 instead of agarose to run electrophoresis.

【在 r*****t 的大作中提到】
: 没看明白
: 什么叫粉条做的RT-PCR?
:
: ..

avatar
l*b
40
就是要让绝大多数的科学家去喝西北风。可以提高基本工资,适当的奖励是可以的,但
是不能有grant抽头之说。grant可以让你有钱做实验,雇人,不是用来给PI买大房子的
。这样一高,以后搞科研的就只剩富二代,或是对science甘愿赴汤蹈火之人了,
science的结果也就可信的多。

【在 f**********e 的大作中提到】
: 韩国造假王黄禹锡在被踢爆前讲的也是这样。这种细活只有我们韩国人能干。
: 科学要纯净,要和铜臭味划清界线?那绝大多数的科学家都得去喝西北风。
:
: authors
: measuring
: the

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