Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway - 未名空间MITBBS历史存档

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Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway# Biology - 生物学

t*82013-10-25 07:10

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p*u2013-10-25 07:10

2 楼

http://www.sciencedirect.com/science/article/pii/S1550413113003
Exercise can improve cognitive function and has been linked to the increased
expression of brain-derived neurotrophic factor (BDNF). However, the
underlying molecular mechanisms driving the elevation of this neurotrophin
remain unknown. Here we show that FNDC5, a previously identified muscle
protein that is induced in exercise and is cleaved and secreted as irisin,
is also elevated by endurance exercise in the hippocampus of mice. Neuronal
Fndc5 gene expression is regulated by PGC-1α, and Pgc1a−/− mice
show reduced Fndc5 expression in the brain. Forced expression of FNDC5 in
primary cortical neurons increases Bdnf expression, whereas RNAi-mediated
knockdown of FNDC5 reduces Bdnf. Importantly, peripheral delivery of FNDC5
to the liver via adenoviral vectors, resulting in elevated blood irisin,
induces expression of Bdnf and other neuroprotective genes in the
hippocampus. Taken together, our findings link endurance exercise and the
important metabolic mediators, PGC-1α and FNDC5, with BDNF expression in
the brain.

A*y2013-10-25 07:10

3 楼

Yes, Bruce M. Spiegelman's post-docs, when irisin worked in human then let
us know. Sounds like another leptin...

I*g2013-10-25 07:10

4 楼

有谁知道内幕的展开说说。Irisin, FNDC5 story 好像不能hold up. 好多公司都不能
重复他的工作。是不是Spiegelman's work 都不大能让人相信。

I*g2013-10-25 07:10

5 楼

最近好像还被人黑了。匿名（假名）把他的结果发表了。估计仇家很多。
http://www.nature.com/news/mystery-over-obesity-fraud-1.13810
Mystery over obesity ‘fraud’
Researcher baffled after his results appear in bogus paper.