Help on synthesizing this product (see attachment) - 未名空间MITBBS历史存档

国际科技财经博客移民网络热点娱乐民生时事公众号

Redian新闻

>未名空间

>Chemistry - 化学

Help on synthesizing this product (see attachment)

Help on synthesizing this product (see attachment)# Chemistry - 化学

T*c2013-10-29 07:10

1 楼

战国狐这个转折太陡了啊
还好最后圆了下乐毅2天前就跑路了，估计还被追杀啥的，不然解释不过去为啥不派个
人来通知一声“狐子啊哥这事儿办砸了哥自身难保你也赶快跑路吧”，狐子找他不好找
，他找狐子还是容易的么。

A*X2013-10-29 07:10

2 楼

Hi All,
I am having difficulties on synthesizing the product below. I can only find
two methods reported in Literature. The first one is way too complicated.
Unless I really don't have any other choices, I would like to leave this
method as my last choice. The second one requires "autoclave", which I
couldn't do at all.
So, can anybody help me on this --- find other ways to synthesize the
product? The method can be just a speculation, as long as it is reasonable.
I can always to give a try to see it will work or not. Thanks in advance.

I*n2013-10-29 07:10

3 楼

已经留了后路了，估计最后主父逃出来跟主角里应外合
不过看来是瞎了

x*i2013-10-29 07:10

4 楼

cross coupling 应该比较靠谱

s*h2013-10-29 07:10

5 楼

作者还号称不虐主!

a*h2013-10-29 07:10

6 楼

第一种靠谱。
Chem. Commun., 2011,47, 5181–5183
看这篇文献，条件一样，只需要变一下锌试剂。

m*s2013-10-29 07:10

7 楼

啊？几天不看就瞎了？这是要闹哪能。。。

s*k2013-10-29 07:10

8 楼

Try a new strategy:
Do the C-H activation at the benzylic position

A*X2013-10-29 07:10

9 楼

Thanks. Actually I tried this one. The chemistry worked fine. But the
problem is that I can only get a mixture of isomers from the coupling
product on the different position of the alky chain. There is no way I can
purify the product from these isomers. They are so close on GC and TLC. So,
I gave up on this method. If anybody has any idea on how to control these
isomers, please let me know. Thanks.

【在 a********h 的大作中提到】

: 第一种靠谱。
: Chem. Commun., 2011,47, 5181–5183
: 看这篇文献，条件一样，只需要变一下锌试剂。

A*X2013-10-29 07:10

10 楼

Thanks. It might be a good approach. Do you have any reference on this? or,
if you have something in your mind, can you share with me. Reaction scheme
would be fine to me. Thanks.

【在 s***k 的大作中提到】

: Try a new strategy:
: Do the C-H activation at the benzylic position