肿瘤在不停的shed cells. 原发肿瘤可以手术切除,那些进入circulation的癌细胞可 以在合适的环境下生存,条件适宜的话会发展成转移的肿瘤。 术后化疗就是为了尽可能杀死这些潜伏的癌细胞。化疗的fractional kill性质,一次 不能杀死全部癌细胞,重复的疗程能尽可能接近全部杀死癌细胞。 这就是其实你母亲的决定是有道理的。清除越干净,复发几率越小,间隔时间越长。 化疗的副作用,换来的其实是更长的生存时间。 一些已经转移的dormant tumor cells是无法被杀死的。他们会静静潜伏多年,在适当 条件下复发。 From Wiki In oncology, the fact that one round of chemotherapy does not kill all the cells in a tumor is a poorly understood phenomenon called fractional kill, or fractional cell kill. The fractional kill hypothesis states that a defined chemotherapy concentration, applied for a defined time period, will kill a constant fraction of the cells in a population, independent of the absolute number of cells [1][2][3]. In solid tumors, poor access of the tumor to the drug can limit the fraction of tumor cells killed, but the validity of the fractional kill hypothesis has also been established in animal models of leukemia, as well as in human leukemia and lymphoma, where drug access is less of an issue[3]. Because only a fraction of the cells die with each treatment, repeated doses must be administered to continue to reduce the size of the tumor [4]. Current chemotherapy regimens apply drug treatment in cycles, with the frequency and duration of treatments limited by toxicity to the patient [3]. The goal is to reduce the tumor population to zero with successive fractional kills [3]. For example, assuming a 99% kill per cycle of chemotherapy, a tumor of 1011 cells would be reduced to less than one cell with six treatment cycles: 1011 * 0.016 < 1 [3]. However, the tumor can also re-grow during the intervals between treatments, limiting the net reduction of each fractional kill [4].
【在 n*********0 的大作中提到】 : 肿瘤在不停的shed cells. 原发肿瘤可以手术切除,那些进入circulation的癌细胞可 : 以在合适的环境下生存,条件适宜的话会发展成转移的肿瘤。 : 术后化疗就是为了尽可能杀死这些潜伏的癌细胞。化疗的fractional kill性质,一次 : 不能杀死全部癌细胞,重复的疗程能尽可能接近全部杀死癌细胞。 : 这就是其实你母亲的决定是有道理的。清除越干净,复发几率越小,间隔时间越长。 : 化疗的副作用,换来的其实是更长的生存时间。 : 一些已经转移的dormant tumor cells是无法被杀死的。他们会静静潜伏多年,在适当 : 条件下复发。 : From Wiki : In oncology, the fact that one round of chemotherapy does not kill all the