If you have general questions, I can answer them here. However, if you want to go for details into the grant, you need to hire professionals. There are several consulting firm doing that. Here are two: http://www.evagarland.com/ http://bbcetc.com/ Your school business development office might be willing to upfront the cost (at least my school does). Btw, some SBIR reviewers are not very good at following SBIR instructions and make stupid comments because no one actually read the application instructional lane to lane even the funded ones. NCI and NINDS study sections are very good though. NIGMS not so much.