审稿机会：Molecular BioSystems（影响因子3.859）# Immigration - 落地生根
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http://www.rsc.org/publishing/journals/MB/About.asp
稿件：
TITLE: Salivary proteins associated with hyperglycemia in diabetes: a
proteomic analysis
摘要：
ABSTRACT: Effective monitoring of glucose levels is necessary for patients
to achieve greater control over their diabetes. However, only about a
quarter of subjects with diabetes who requires close serum glucose
monitoring, regularly check their serum glucose daily. One of the potential
barriers to patient compliance is the blood sampling requirement. Saliva and
its protein contents can be altered in subjects with diabetes, possibly due
to changes in glycemic control. We propose here that salivary proteomes of
subjects with diabetes may be different based on their glycemic control as
reflected in A1C levels. A total of 153 subjects with type 1 or 2 diabetes
were recruited. Subjects in each type of diabetes were divided into 5 groups
based on their A1C levels; <7, 7-8, 8-9, 9-10, >10. To examine the global
proteomic changes associated with A1C, the proteomic profiling of pooled
saliva samples from each group was created using label-free quantitative
proteomics. Similar proteomic analysis for individual subjects (N=4, for
each group) were then applied to examine proteins that may be less abundant
in pooled samples. Principle component analysis (PCA) and cluster analysis (
p<0.01 and p<0.001) were used to define the proteomic differences. We,
therefore, defined the salivary proteomic changes associated with A1C
changes. This study demonstrates that differences exist between salivary
proteomic profiles in subjects with diabetes based on the A1C levels.
如果你感兴趣，请站内信告诉我你的名字，email，关键词(expertise)。
谢谢！
http://www.rsc.org/publishing/journals/MB/About.asp
稿件：
TITLE: Salivary proteins associated with hyperglycemia in diabetes: a
proteomic analysis
摘要：
ABSTRACT: Effective monitoring of glucose levels is necessary for patients
to achieve greater control over their diabetes. However, only about a
quarter of subjects with diabetes who requires close serum glucose
monitoring, regularly check their serum glucose daily. One of the potential
barriers to patient compliance is the blood sampling requirement. Saliva and
its protein contents can be altered in subjects with diabetes, possibly due
to changes in glycemic control. We propose here that salivary proteomes of
subjects with diabetes may be different based on their glycemic control as
reflected in A1C levels. A total of 153 subjects with type 1 or 2 diabetes
were recruited. Subjects in each type of diabetes were divided into 5 groups
based on their A1C levels; <7, 7-8, 8-9, 9-10, >10. To examine the global
proteomic changes associated with A1C, the proteomic profiling of pooled
saliva samples from each group was created using label-free quantitative
proteomics. Similar proteomic analysis for individual subjects (N=4, for
each group) were then applied to examine proteins that may be less abundant
in pooled samples. Principle component analysis (PCA) and cluster analysis (
p<0.01 and p<0.001) were used to define the proteomic differences. We,
therefore, defined the salivary proteomic changes associated with A1C
changes. This study demonstrates that differences exist between salivary
proteomic profiles in subjects with diabetes based on the A1C levels.
如果你感兴趣，请站内信告诉我你的名字，email，关键词(expertise)。
谢谢！
