女人的福音：60岁生娃不是梦了 - 未名空间MITBBS历史存档

女人的福音：60岁生娃不是梦了# Piebridge - 鹊桥

s*92012-02-27 08:02

1 楼

NOW 20% off everything
sorry can't type Chinese now
I bought there twice, but each time I feel like the products don't have a
high quality
Anyone has the good experience for that?
Thank you!!

l*92012-02-27 08:02

2 楼

http://www.businessweek.com/news/2012-02-27/ovarian-stem-cells-
Ovarian Stem Cells Make Human Eggs in Possible Aid to Fertility
By Ryan Flinn
Feb. 27 (Bloomberg) -- Stem cells taken from human ovaries were used to
produce early-stage eggs by scientists in Boston who may have created a new
method to help infertile women.
Females have a fixed number of eggs from birth that are depleted by the time
of menopause. The finding, published today in the journal Nature Medicine,
challenges the belief that their ovaries can’t make more. The research was
led by Jonathan Tilly, the director of Massachusetts General Hospital’s
Vincent Center for Reproductive Biology.
Tilly reported in 2004 that ovarian stem cells in mice create new eggs, or
oocytes, in a way similar to how stem cells in male testes produce sperm
throughout a man’s life. His latest work, if reproduced, would suggest the
same is true for human ovaries, potentially pointing at new ways to aid
fertility by delaying when the ovaries stop functioning.
“The 50-year-old belief in our field wasn’t actually based on data proving
it was impossible, or not ongoing,” Tilly said in a telephone interview.
“It was simply an assumption made because there was no evidence indicating
otherwise. We have human cells that can produce new oocytes.”
In the study, healthy ovaries were obtained from consenting patients
undergoing sex reassignment surgery. The researchers were able to identify
ovarian stem cells because they express a rare protein that’s only seen in
reproductive cells.
The stem cells from the ovaries were injected into human ovarian tissue that
was then grafted under the skin of mice, which provided the blood supply
that enabled growth. Within two weeks, early stage human follicles with
oocytes had formed.
7-Million Eggs
A female is most endowed with oocytes, or eggs, as a fetus, when she has
about 7 million. That number that drops to 1 million by birth, and around
300,000 by puberty. By menopause, the number is zero. Since the 1950’s,
scientists thought that ovarian stem cells capable of producing new eggs are
only active during fetal development.
“This paper essentially opens the door to the ability to control oocyte
development in human ovaries,” Tilly said.
About 10 percent of women of child-bearing age in the U.S., or 6.1 million,
have difficulty getting pregnant or staying pregnant, according to the
Centers for Disease Control and Prevention. Most cases of female infertility
are caused by problems with ovulation, hormone imbalance or age.
The study by Tilley and his colleagues offers “a new model system for
understanding the human egg cell,” said David F. Albertini, director of the
Center for Reproductive Services and professor in the department of
molecular and integrative physiology at Kansas University, in a telephone
interview.
‘Practical Applications”
Still, “there’s a long way to go before this has real practical
applications. I’ve spent 35 years of my life studying egg cells and this is
a cell that is at least as complicated as a neuron in the brain, if not
more,” Albertini said.
The work needs to be reproduced and expanded by other scientists “to make
it into something that will make us confident the cells are safe to use and
we could actually use them to repopulate an egg-depleted ovary,” he said.
Tilly’s team is exploring the development of an ovarian stem-cell bank that
can be cryogenically frozen and thawed without damage, unlike human eggs,
he said. The researchers are also working to identify hormones and other
growth factors for accelerating production of eggs from human ovarian stem
cells and ways to improve in-vitro fertilization.
“The problem we face with IVF is we don’t have many eggs to work with,”
he said. “These cells are renewable. If we are successful -- and it’s a
big if -- in generating functioning eggs from these cells, we can generate
as many eggs as we need to on a per patient basis.”
Tilly is also collaborating with researchers at the University of Edinburgh
in the U.K. to determine whether the oocytes can be developed into fully
mature human eggs for fertilizing. The U.S bans creating or fertilizing
embryos for experimental purposes, he said.
A company Tilly co-founded, Boston-based OvaScience Inc., has licensed the
technology for potential commercial applications.
--With assistance from Sarah Frier in New York. Editors: Angela Zimm, Andrew
Pollack
To contact the reporter on this story: Ryan Flinn in San Francisco at rflinn
@bloomberg.net
To contact the editor responsible for this story: Reg Gale at [email protected]
bloomberg.net

P*d2012-02-27 08:02

3 楼

退休金都要给baby买奶粉了。。。

l*92012-02-27 08:02

4 楼

找嫩牛

【在 P******d 的大作中提到】

: 退休金都要给baby买奶粉了。。。