Key word: ActRIIB Antagonism, muscle mouse, dramatic prolonged survival,
ubiquitin-proteasome system, Muscle Stem cell
这篇文章很有意思, 肌肉鼠得了癌症后,40天基本不死,对照组基本死光。
doi:10.1016/j.cell.2010.07.011
Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism
Leads to Prolonged Survival
Xiaolan Zhou1, Jin Lin Wang1, John Lu1, Yanping Song1, Keith S. Kwak1,
Qingsheng Jiao1, Robert Rosenfeld1, Qing Chen1, Thomas Boone1, W. Scott
Simonet1, David L. Lacey1, Alfred L. Goldberg2 and H.Q. Han1, ,
1 Departme