Science Express Index Reports Calcium-Permeable AMPA Receptor Dynamics Mediate Fear Memory Erasure Roger L. Clem and Richard L. Huganir* Traumatic fear memories can be inhibited by behavioral therapy or extinction training in rodent models, but are prone to relapse. Under some conditions, however, these treatments generate a permanent effect on behavior suggesting emotional memory erasure. The neural basis for such disparate outcomes is unknown. We found that a central component of extinction-induced erasure is the synaptic removal of calcium-permeable {alpha}-amino-3- hydroxyl-5-methyl-4-isoxazole-propionate receptors (AMPARs) in the lateral amygdala. A transient upregulation of this form of plasticity, which involves phosphorylation of the glutamate receptor 1 subunit of the AMPA receptor, defines a temporal window in which fear memory can be degraded by behavioral experience. These results provide a molecular mechanism for fear erasure and the relative instability of recent memory. Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. * To whom correspondence should be addressed. E-mail: r******[email protected] Received for publication 19 July 2010. Accepted for publication 15 October 2010.
a*a
10 楼
多谢,看到版面前面有人说打电话给amx啥的,以为还可以合并。。。
y*r
11 楼
怎么忽悠的bale主演的...
【在 f****g 的大作中提到】 : another crap by zhang
m*g
12 楼
谢谢. 今天硬件区冷清啊, 还是说这个用过的人不多?
【在 y**b 的大作中提到】 : x201很好,前几天烧瓶版还有deal : : 何,
n*k
13 楼
not new anymore, there was PKC inhibitor I believe
extinction conditions,
【在 s******y 的大作中提到】 : http://www.sciencemag.org/cgi/content/abstract/science.1195298 : Published Online October 28, 2010 : Science DOI: 10.1126/science.1195298 : : Science Express Index : Reports : Calcium-Permeable AMPA Receptor Dynamics Mediate Fear Memory Erasure : Roger L. Clem and Richard L. Huganir* : Traumatic fear memories can be inhibited by behavioral therapy or extinction : training in rodent models, but are prone to relapse. Under some conditions,
r*e
14 楼
人民币升值了
【在 y*r 的大作中提到】 : 怎么忽悠的bale主演的...
g*g
15 楼
好机器,没啥可说的
s*y
16 楼
PKC inhibitor? Can you explain a little bit more about this? I don't know too much about other neuronal things but PKC is one of the enzyme I sometimes work with.
【在 n********k 的大作中提到】 : not new anymore, there was PKC inhibitor I believe : : extinction : conditions,
【在 s******y 的大作中提到】 : PKC inhibitor? : Can you explain a little bit more about this? : I don't know too much about other neuronal things but PKC is one of the : enzyme I sometimes work with.
Really cool! I think the big question now under what normal conditions is this mechanism activated.
extinction conditions,
【在 s******y 的大作中提到】 : http://www.sciencemag.org/cgi/content/abstract/science.1195298 : Published Online October 28, 2010 : Science DOI: 10.1126/science.1195298 : : Science Express Index : Reports : Calcium-Permeable AMPA Receptor Dynamics Mediate Fear Memory Erasure : Roger L. Clem and Richard L. Huganir* : Traumatic fear memories can be inhibited by behavioral therapy or extinction : training in rodent models, but are prone to relapse. Under some conditions,
Curious why women have never complained the weight of their rediculously large handbags and pounds and pounds of stuffs inside the bag.
y*b
49 楼
本子办公,无论在家还是在办公室,是不能不接外界大屏幕的。 出差在外也就凑合一下了。
【在 g******z 的大作中提到】 : 我完全无法忍受13"一下的办公用本
p*t
50 楼
因为她们已经背了那么多东西了(而且对她们来说那些东西显然是比电脑更 重要的),所以电脑必需要够轻
【在 n***s 的大作中提到】 : Curious why women have never complained the weight of their rediculously : large handbags and pounds and pounds of stuffs inside the bag.
j*g
51 楼
乌龟还不嫌壳重呢
【在 n***s 的大作中提到】 : Curious why women have never complained the weight of their rediculously : large handbags and pounds and pounds of stuffs inside the bag.