seems not correlated. if one gene has high level of expression, it should be in low methylation. does that also mean it has more copies? any literature is appreciated
literature 的懒得找 起码有个极端的例子, 脆性X 是FMR1 基因promoter 的CGG重复次数过度增加造成启动 子甲基化降低FMR1表达 ”if one gene has high level of expression, it should be in low methylation. “ 这个大部分时候成立,但是印象中也有反例 ”does that also mean it has more copies?“ 一个基因高表达,可能的原因太多了。多copy当然是可能的原因,也可能是低甲基化, 也有可能是某种转录因子上调/下调,也有可能是细胞活性增加。。。你最多可以说it has more copies, so one gene has high level of expression,而不是你刚才那样 反过来叙述
【在 e*****t 的大作中提到】 : seems not correlated. : if one gene has high level of expression, it should be in low methylation. : does that also mean it has more copies? : any literature is appreciated