y*b
2 楼
想买GSM unlocked 的iphone 6或者iphone 6+,怎么买便宜啊
S*1
3 楼
PhD student position available
Department of Molecular Cell Biology, Leiden University Medical Center, The
Netherlands
Overview of the project and role
We are looking to recruit a PhD student to investigate the role of TGF-
61538; family members in liver fibrosis and cancer. A combination of
molecular biology, biochemistry, cell biology and animal model based
techniques will be used. The research project will be performed at the
Department of Molecular Cell Biology, Leiden University Medical Centre under
supervision of Prof. Dr. P. ten Dijke. This project is supported by a Marie
Curie ITN training programme grant from the European Community and involves
multiple laboratories within Europe. The PhD-student is responsible for
planning and performing the experiments and reporting and publishing the
results in scientific journals and international conferences.
The specific aims of the ITN Training programme are to:
• Provide talented early-stage researchers a research training
programme aimed at acquisition of
o state-of-the-art knowledge of the components of the skills spectrum
needed to combat liver fibrosis and cancer , i.e. science and technologies
of basic molecular liver cell biology, drug discovery and delivery systems
and development of preclinical models and (pre)clinical treatment modalities.
o the ability to assimilate the individual components of the skills
spectrum such that they will be able to oversee and in a goal-oriented
manner direct the multisectorial process of combating diseases.
• Improve employability of its trainees in the higher ranks of
academia and industry by enhancing their transferable skills e.g. in writing
, communication, intellectual property management, valorisation and
entrepreneurship.
• Strengthen research cooperation to advance our understanding of
the molecular and cellular mechanisms of disease progression and to
translate this knowledge into drug discovery and treatment modalities.
The department
Description of our Research Group: TGF-β signal transduction in disease.
In our research group we investigate signal transduction pathways of
transforming growth factor-β (TGF-β) in heath and disease. TGF- is
a secreted homodimeric protein that regulates numerous responses, such as
proliferation, differentiation, migration and apoptosis. TGF-β is the
prototypic member of a family of 33 structurally related pleiotropic
cytokines. Members of the TGF-β superfamily have crucial roles in
development and tissue homeostasis. We are interested in unraveling
mechanisms by which transforming growth factor-β (TGF-β) family members
elicit their multifunctional cellular effects and how perturbation in their
signal transduction pathways contribute to human diseases. The present focus
within our group is on 1) the identification of novel critical regulators
of TGF-β family signaling pathways using functional genetic screens, 2) how
TGF-β specificity and bioavailability is regulated via known (co-)
receptors and ligand binding proteins and 3) interplay with other signaling
pathways. In particular, we study the involvement of TGF-β family members
in the metastasis of cancer cells, tumor angiogenesis and liver disease. We
use 3-dimensional cell culture systems that allow for a functional analysis
of homo- and heterotypic cell-cell interactions in structures that resemble
those found in vivo. Moreover, mouse models are used that mimic diseases
with misregulated TGF-β signaling. Our long term aim is to translate our
findings towards the development of novel treatment modalities.
See also our web site:
http://www.lumc.nl/con/1050/85468/812090135182537/8121001255725
Your profile
All suitably qualified candidates irrespective of gender or nationality are
welcome to apply as long as the following conditions have been fulfilled:
• Applicants should have good knowledge of English, both written
and oral in order to be able to submit reports in English.
• Applicants should be in the first 4 years (full-time equivalent)
of their research careers, including the period of research training,
starting at the date of obtaining the degree which would formally entitle
them to embark on a doctorate.
• Applicants should not have resided or performed their main
activity in Netherlands for more than 12 months in the 3 year period
immediately prior to the start date
• We are looking for an enthusiastic candidate with talent for
experimental research and keen to answer important biomedical research
questions. PhD students involved in this project are encouraged to make
short-term exchange visits.
The ESR fellow is supposed to complete his/her PhD thesis by the end of the
3rd year of his/her employment.
We offer
You will be employed on the basis of a 36-hour week. Appointment is for the
duration of the program. Your salary will be 2,141 gross per month in the
first year, going up to 2,743 gross per month in the last year (scale
PhD of the Collective Labor Agreement for University Hospitals).
More information
If you have any questions or if you want more information about this
position, please contact Prof. Dr. P. ten Dijke, Department of Molecular
Cell Biology, telephone (+31) 071 526 9270, email p*********[email protected]
Two recent papers from our lab:
Zhang L, Huang H, Zhou F, Schimmel J, Gontan Pardo C, Zhang T, Barakat TS,
Sheppard KA, Mickanin C, Porter JA, Vertegaal ACO, van Dam H, Gribnau J,
Chris X. Lu, ten Dijke P. (2012) RNF12 controls embryonic stem cell fate and
morphogenesis in zebrafish embryos by targeting Smad7 for degradation. Mol
Cell, 46:650-61.
Zhang L, Zhou F, Drabsch Y, Snaar-Jagalska E, Mickanin C, Huang H, Sheppard
K-A, Lu C, and ten Dijke P. (2012) USP4 is regulated by Akt phosphorylation
and deubiquitinates TGF-β type I receptor. Nat Cell Biology, 14:717-26
Department of Molecular Cell Biology, Leiden University Medical Center, The
Netherlands
Overview of the project and role
We are looking to recruit a PhD student to investigate the role of TGF-
61538; family members in liver fibrosis and cancer. A combination of
molecular biology, biochemistry, cell biology and animal model based
techniques will be used. The research project will be performed at the
Department of Molecular Cell Biology, Leiden University Medical Centre under
supervision of Prof. Dr. P. ten Dijke. This project is supported by a Marie
Curie ITN training programme grant from the European Community and involves
multiple laboratories within Europe. The PhD-student is responsible for
planning and performing the experiments and reporting and publishing the
results in scientific journals and international conferences.
The specific aims of the ITN Training programme are to:
• Provide talented early-stage researchers a research training
programme aimed at acquisition of
o state-of-the-art knowledge of the components of the skills spectrum
needed to combat liver fibrosis and cancer , i.e. science and technologies
of basic molecular liver cell biology, drug discovery and delivery systems
and development of preclinical models and (pre)clinical treatment modalities.
o the ability to assimilate the individual components of the skills
spectrum such that they will be able to oversee and in a goal-oriented
manner direct the multisectorial process of combating diseases.
• Improve employability of its trainees in the higher ranks of
academia and industry by enhancing their transferable skills e.g. in writing
, communication, intellectual property management, valorisation and
entrepreneurship.
• Strengthen research cooperation to advance our understanding of
the molecular and cellular mechanisms of disease progression and to
translate this knowledge into drug discovery and treatment modalities.
The department
Description of our Research Group: TGF-β signal transduction in disease.
In our research group we investigate signal transduction pathways of
transforming growth factor-β (TGF-β) in heath and disease. TGF- is
a secreted homodimeric protein that regulates numerous responses, such as
proliferation, differentiation, migration and apoptosis. TGF-β is the
prototypic member of a family of 33 structurally related pleiotropic
cytokines. Members of the TGF-β superfamily have crucial roles in
development and tissue homeostasis. We are interested in unraveling
mechanisms by which transforming growth factor-β (TGF-β) family members
elicit their multifunctional cellular effects and how perturbation in their
signal transduction pathways contribute to human diseases. The present focus
within our group is on 1) the identification of novel critical regulators
of TGF-β family signaling pathways using functional genetic screens, 2) how
TGF-β specificity and bioavailability is regulated via known (co-)
receptors and ligand binding proteins and 3) interplay with other signaling
pathways. In particular, we study the involvement of TGF-β family members
in the metastasis of cancer cells, tumor angiogenesis and liver disease. We
use 3-dimensional cell culture systems that allow for a functional analysis
of homo- and heterotypic cell-cell interactions in structures that resemble
those found in vivo. Moreover, mouse models are used that mimic diseases
with misregulated TGF-β signaling. Our long term aim is to translate our
findings towards the development of novel treatment modalities.
See also our web site:
http://www.lumc.nl/con/1050/85468/812090135182537/8121001255725
Your profile
All suitably qualified candidates irrespective of gender or nationality are
welcome to apply as long as the following conditions have been fulfilled:
• Applicants should have good knowledge of English, both written
and oral in order to be able to submit reports in English.
• Applicants should be in the first 4 years (full-time equivalent)
of their research careers, including the period of research training,
starting at the date of obtaining the degree which would formally entitle
them to embark on a doctorate.
• Applicants should not have resided or performed their main
activity in Netherlands for more than 12 months in the 3 year period
immediately prior to the start date
• We are looking for an enthusiastic candidate with talent for
experimental research and keen to answer important biomedical research
questions. PhD students involved in this project are encouraged to make
short-term exchange visits.
The ESR fellow is supposed to complete his/her PhD thesis by the end of the
3rd year of his/her employment.
We offer
You will be employed on the basis of a 36-hour week. Appointment is for the
duration of the program. Your salary will be 2,141 gross per month in the
first year, going up to 2,743 gross per month in the last year (scale
PhD of the Collective Labor Agreement for University Hospitals).
More information
If you have any questions or if you want more information about this
position, please contact Prof. Dr. P. ten Dijke, Department of Molecular
Cell Biology, telephone (+31) 071 526 9270, email p*********[email protected]
Two recent papers from our lab:
Zhang L, Huang H, Zhou F, Schimmel J, Gontan Pardo C, Zhang T, Barakat TS,
Sheppard KA, Mickanin C, Porter JA, Vertegaal ACO, van Dam H, Gribnau J,
Chris X. Lu, ten Dijke P. (2012) RNF12 controls embryonic stem cell fate and
morphogenesis in zebrafish embryos by targeting Smad7 for degradation. Mol
Cell, 46:650-61.
Zhang L, Zhou F, Drabsch Y, Snaar-Jagalska E, Mickanin C, Huang H, Sheppard
K-A, Lu C, and ten Dijke P. (2012) USP4 is regulated by Akt phosphorylation
and deubiquitinates TGF-β type I receptor. Nat Cell Biology, 14:717-26
O*O
4 楼
NIW要
EB1不要
【在 c****n 的大作中提到】
: 申请NIW和EB1A需不需要填写ETA-750B？谢谢。
EB1不要
【在 c****n 的大作中提到】
: 申请NIW和EB1A需不需要填写ETA-750B？谢谢。
y*b
5 楼
up
c*n
6 楼
非常感谢！请问哪里有填写ETA-750B的sample？
【在 O*O 的大作中提到】
: NIW要
: EB1不要
【在 O*O 的大作中提到】
: NIW要
: EB1不要
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