清洁用品里的灭菌剂和过敏的发生有关系# Biology - 生物学
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John Hopkins 的研究人员发现，过多的使用灭菌剂，会导致小孩容易发生过敏。
Antibacterials in Personal-Care Products Linked to Allergy Risk in Children
Exposure to common antibacterial chemicals and preservatives found in soap,
toothpaste, mouthwash and other personal-care products may make children
more prone to a wide range of food and environmental allergies, according to
new research from Johns Hopkins Children’s Center.
Results of the NIH-funded study are published online ahead of print June 18
in the Journal of Allergy and Clinical Immunology.
Using existing data from a national health survey of 860 children ages 6 to
18, Johns Hopkins researchers examined the relationship between a child’s
urinary levels of antibacterials and preservatives found in many personal-
hygiene products and the presence of IgE antibodies in the child’s blood.
IgE antibodies are immune chemicals that rise in response to an allergen and
are markedly elevated in people with allergies.
“We saw a link between level of exposure, measured by the amount of
antimicrobial agents in the urine, and allergy risk, indicated by
circulating antibodies to specific allergens,” said lead investigator
Jessica Savage, M.D., M.H.S., an allergy and immunology fellow at Hopkins.
The researchers caution that the findings do not demonstrate that
antibacterials and preservatives themselves cause the allergies, but instead
suggest that these agents play a role in immune system development.
The investigators say their findings are also consistent with the so-called
hygiene hypothesis, which has recently gained traction as one possible
explanation behind the growing rates of food and environmental allergies in
the developed world. The hypothesis suggests that early childhood exposure
to common pathogens is essential in building healthy immune responses. Lack
of such exposure, according to the theory, can lead to an overactive immune
system that misfires against harmless substances such as food proteins,
pollen or pet dander.
“The link between allergy risk and antimicrobial exposure suggests that
these agents may disrupt the delicate balance between beneficial and bad
bacteria in the body and lead to immune system dysregulation, which in turn
raises the risk of allergies,” Savage added.
In the study, those with the highest urine levels of triclosan — an
antibacterial agent used in soaps, mouthwash and toothpaste — had the
highest levels of food IgE antibodies, and therefore the highest allergy
risk, compared with children with the lowest triclosan levels. Children with
the highest urinary levels of parabens — preservatives with antimicrobial
properties used in cosmetics, food and medications — were more likely to
have detectable levels of IgE antibodies to environmental allergens like
pollen and pet dander, compared with those with low paraben levels.
The team initially zeroed in on seven ingredients previously shown to
disrupt endocrine function in lab and animal studies. These compounds were
bisphenol A — found in plastics — and triclosan, benzophenone-3 and propyl
, methyl, butyl and ethyl parabens, found in personal-hygiene products and
some foods and medications. Interestingly, triclosan and propyl and butyl
parabens, all of which have antimicrobial properties, were the only ones
associated with increased allergy risk in the current study, the researchers
noted.
“This finding highlights the antimicrobial properties of these agents as a
probable driving force behind their effect on the immune system,” said
senior investigatorCorinne Keet, M.D., M.S., an allergist at Johns Hopkins
Children’s Center.
Children with the highest urine levels of triclosan had nearly twice the
risk of environmental allergies as children with the lowest urinary
concentrations. Those with highest levels of propyl paraben in the urine had
twice the risk of an environmental allergy. Food allergy risk was more than
twice as pronounced in children with the highest levels of urinary
triclosan as in children with the lowest triclosan levels. High paraben
levels in the urine were not linked to food allergy risk.
To clarify the link between antimicrobial agents and allergy development,
the researchers are planning a long-term study in babies exposed to
antibacterial ingredients at birth, following them throughout childhood.
Antibacterials in Personal-Care Products Linked to Allergy Risk in Children
Exposure to common antibacterial chemicals and preservatives found in soap,
toothpaste, mouthwash and other personal-care products may make children
more prone to a wide range of food and environmental allergies, according to
new research from Johns Hopkins Children’s Center.
Results of the NIH-funded study are published online ahead of print June 18
in the Journal of Allergy and Clinical Immunology.
Using existing data from a national health survey of 860 children ages 6 to
18, Johns Hopkins researchers examined the relationship between a child’s
urinary levels of antibacterials and preservatives found in many personal-
hygiene products and the presence of IgE antibodies in the child’s blood.
IgE antibodies are immune chemicals that rise in response to an allergen and
are markedly elevated in people with allergies.
“We saw a link between level of exposure, measured by the amount of
antimicrobial agents in the urine, and allergy risk, indicated by
circulating antibodies to specific allergens,” said lead investigator
Jessica Savage, M.D., M.H.S., an allergy and immunology fellow at Hopkins.
The researchers caution that the findings do not demonstrate that
antibacterials and preservatives themselves cause the allergies, but instead
suggest that these agents play a role in immune system development.
The investigators say their findings are also consistent with the so-called
hygiene hypothesis, which has recently gained traction as one possible
explanation behind the growing rates of food and environmental allergies in
the developed world. The hypothesis suggests that early childhood exposure
to common pathogens is essential in building healthy immune responses. Lack
of such exposure, according to the theory, can lead to an overactive immune
system that misfires against harmless substances such as food proteins,
pollen or pet dander.
“The link between allergy risk and antimicrobial exposure suggests that
these agents may disrupt the delicate balance between beneficial and bad
bacteria in the body and lead to immune system dysregulation, which in turn
raises the risk of allergies,” Savage added.
In the study, those with the highest urine levels of triclosan — an
antibacterial agent used in soaps, mouthwash and toothpaste — had the
highest levels of food IgE antibodies, and therefore the highest allergy
risk, compared with children with the lowest triclosan levels. Children with
the highest urinary levels of parabens — preservatives with antimicrobial
properties used in cosmetics, food and medications — were more likely to
have detectable levels of IgE antibodies to environmental allergens like
pollen and pet dander, compared with those with low paraben levels.
The team initially zeroed in on seven ingredients previously shown to
disrupt endocrine function in lab and animal studies. These compounds were
bisphenol A — found in plastics — and triclosan, benzophenone-3 and propyl
, methyl, butyl and ethyl parabens, found in personal-hygiene products and
some foods and medications. Interestingly, triclosan and propyl and butyl
parabens, all of which have antimicrobial properties, were the only ones
associated with increased allergy risk in the current study, the researchers
noted.
“This finding highlights the antimicrobial properties of these agents as a
probable driving force behind their effect on the immune system,” said
senior investigatorCorinne Keet, M.D., M.S., an allergist at Johns Hopkins
Children’s Center.
Children with the highest urine levels of triclosan had nearly twice the
risk of environmental allergies as children with the lowest urinary
concentrations. Those with highest levels of propyl paraben in the urine had
twice the risk of an environmental allergy. Food allergy risk was more than
twice as pronounced in children with the highest levels of urinary
triclosan as in children with the lowest triclosan levels. High paraben
levels in the urine were not linked to food allergy risk.
To clarify the link between antimicrobial agents and allergy development,
the researchers are planning a long-term study in babies exposed to
antibacterial ingredients at birth, following them throughout childhood.
