deregulated pathway - 未名空间MITBBS历史存档

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deregulated pathway

deregulated pathway# Biology - 生物学

m*i2014-09-08 07:09

1 楼

今天早上去面试，老婆是绿卡，我们都有2个小孩。
面试官说了对我们没什么问题，就问了点基本的东西，说要批了。我问就不用等visa了
吗？他说不用，可以发绿卡了。
我说我是f2a，排期倒退了。他坚持他的，不过最后他还是去问了supervisor，等了一
会，回来脸色很不好看，看到我们在笑，说我们没有respect。他还威胁说楼下有ice官
员，blablabla 我说我们没有在笑他，而是笑可能马上拿到绿卡了。
然后他说确实要等visa,居然给我的表格上写further review，怎么办？
真是郁闷，早知道什么都不说，就拿绿卡了。

c*e2014-09-08 07:09

2 楼

att 升级了个iphone 5合约机，想要出掉，是不是要开封激活后才能出？出掉后对自
己的套餐有影响么，谢谢各位大神指教~

G*G2014-09-08 07:09

3 楼

what is the definition of 'deregulated pathway?'

l*52014-09-08 07:09

4 楼

有时候多嘴真不是好事， IO说给你GC你等着就是了， ARGUE什么啊？

x*s2014-09-08 07:09

5 楼

I think it means the pathway is not working normally as it is supposed to be
. In normal cells, numerous cellular pathways are being precisely regulated
to ensure a normal functional output. However, in the case of cancer, the
situation of pathways is usually found quite different. For example, p53
inactivation is frequently observed in many cancer types. This molecule is
critical in DNA repair, cell cycle as well as apoptosis of host cells.
Therefore, abnormality of this molecule would cause an impaired or
deregulated p53 signaling.

i*02014-09-08 07:09

6 楼

就是upregulated+downregulated的pathway集合吧。

h*o2014-09-08 07:09

7 楼

deregulated pathway means pathway without regulation.
It is different from dysregulated pathway, which is much more commonly seen/
used in scientific writing context.