关于Zika病毒抑制剂筛选的新进展 - 未名空间MITBBS历史存档

国际科技财经博客移民网络热点娱乐民生时事公众号

Redian新闻

>未名空间

>Biology - 生物学

关于Zika病毒抑制剂筛选的新进展

关于Zika病毒抑制剂筛选的新进展# Biology - 生物学

c*62018-03-04 08:03

1 楼

High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates
that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain.
Ting Zhou11, Lei Tan11, Gustav Y. Cederquist11, Yujie Fan, Brigham J.
Hartley, Suranjit Mukherjee, Mark Tomishima, Kristen J. Brennand, Qisheng
Zhang, Robert E. Schwartz, Todd Evans, Lorenz Studer'Correspondence
information about the author Lorenz StuderEmail the author Lorenz Studer,
Shuibing Chen12,'Correspondence information about the author Shuibing Chen
究竟有没有人重复出该文中 hippeastrine hydrobromide (HH) and amodiaquine
dihydrochloride dihydrate (AQ) 抑制Zika病毒感染in vitro干细胞？

c*62018-03-04 08:03

2 楼

为什么没有任何杂志讨论这么好的药物？

Candidates

【在 c********6 的大作中提到】

: High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates
: that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain.
: Ting Zhou11, Lei Tan11, Gustav Y. Cederquist11, Yujie Fan, Brigham J.
: Hartley, Suranjit Mukherjee, Mark Tomishima, Kristen J. Brennand, Qisheng
: Zhang, Robert E. Schwartz, Todd Evans, Lorenz Studer'Correspondence
: information about the author Lorenz StuderEmail the author Lorenz Studer,
: Shuibing Chen12,'Correspondence information about the author Shuibing Chen
: 究竟有没有人重复出该文中 hippeastrine hydrobromide (HH) and amodiaquine
: dihydrochloride dihydrate (AQ) 抑制Zika病毒感染in vitro干细胞？

c*62018-03-04 08:03

3 楼

Perfect data.

c*62018-03-04 08:03

4 楼

非常好奇，这种实验的重复应该是很快的，没有什么技术含量。

c*62018-03-04 08:03

5 楼

c*62018-03-04 08:03

6 楼

为什么没有任何杂志讨论这么好的药物？

Candidates

【在 c********6 的大作中提到】

c*62018-03-04 08:03

7 楼

Perfect data.

c*62018-03-04 08:03

8 楼

非常好奇，这种实验的重复应该是很快的，没有什么技术含量。

b*e2018-03-04 08:03

9 楼

读了一下这篇文章，不喜欢这种研究思路，不能够称之为科学。
该实验室主页上面所挂出来的以下一些文章中，有很多引用率非常的低。
ROCKII inhibition promotes the maturation of human pancreatic beta-like
cells. Nature Communications. 2017 Academic Article GET IT
High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates
that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain.
Cell Stem Cell. 2017 Academic Article GET IT
A Modular Platform for Differentiation of Human PSCs into All Major
Ectodermal Lineages. Cell Stem Cell. 2017 Academic Article GET IT
An Integrated Systems Biology Approach Identifies TRIM25 as a Key
Determinant of Breast Cancer Metastasis. Cell Reports. 2017 Academic
Article GET IT
Times cited: 3
Colonic organoids derived from human induced pluripotent stem cells for
modeling colorectal cancer and drug testing. Nature Medicine. 2017
Academic Article GET IT
Times cited: 6
Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1
and MT1E. Cell Reports. 2017 Academic Article GET IT
Times cited: 1
Efficient generation of cardiac purkinje-like cells from embryonic stem
cells by activating cAMP signaling. Current protocols in stem cell biology.
2017 Academic Article GET IT
Times cited: 1
Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug
sensitivity of acute myeloid leukemia cells. Scientific Reports. 2017
Academic Article GET IT
Multifunctional in vivo imaging of pancreatic islets during diabetes
development. Journal of Cell Science. 2016 Academic Article GET IT
Times cited: 3
Discovery of a Small-Molecule BMP Sensitizer for Human Embryonic Stem Cell
Differentiation. Cell Reports. 2016 Academic Article GET IT
Times cited: 1
Deriving human ENS lineages for cell therapy and drug discovery in
Hirschsprung disease. Nature. 2016 Academic Article GET IT
Times cited: 47
A recellularized human colon model identifies cancer driver genes. Nature
Biotechnology. 2016 Academic Article GET IT
Times cited: 17
Dynamic self-organization of microwell-aggregated cellular mixtures. Soft
Matter. 2016 Academic Article GET IT
Times cited: 4
Modeling cystic fibrosis using pluripotent stem cell-derived human
pancreatic ductal epithelial cells. Stem Cells Translational Medicine.
2016 Academic Article GET IT
Times cited: 5
An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-
Association-Study-Identified Diabetes Genes and Drug Discovery. Cell Stem
Cell. 2015 Academic Article GET IT
Times cited: 8
Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic
Interaction with GATA4 in Human Pancreatic Development. Cell Stem Cell.
2015 Academic Article GET IT
Times cited: 12
Efficient Generation of Cardiac Purkinje Cells from ESCs by Activating cAMP
Signaling. Stem Cell Reports. 2015 Academic Article GET IT
Times cited: 7
Endothelial cells control pancreatic cell fate at defined stages through
EGFl7 signaling. Stem Cell Reports. 2015 Academic Article GET IT
Times cited: 14
Nanofibrous microposts and microwells of controlled shapes and their
hybridization with hydrogels for cell encapsulation. ACS Applied Materials
and Interfaces. 2014 Article GET IT
Times cited: 10
Pluripotent stem cell-derived pancreatic -cells: Potential for regenerative
medicine in diabetes. Regenerative Medicine. 2012 Review GET IT
Times cited: 5
Cardiac glycosides are potent inhibitors of interferon-β gene expression.
Nature Chemical Biology. 2011 Academic Article GET IT
Times cited: 26
Generation of pluripotent stem cells from patients with type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of
America. 2009 Academic Article GET IT
Times cited: 341
Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and
Human Embryonic Stem Cells. Cell Stem Cell. 2009 Academic Article GET IT
Times cited: 268
A small molecule that directs differentiation of human ESCs into the
pancreatic lineage. Nature Chemical Biology. 2009 Academic Article GET IT
Times cited: 327
Induction of pluripotent stem cells from primary human fibroblasts with only
Oct4 and Sox2. Nature Biotechnology. 2008 Academic Article GET IT
Times cited: 949
The Renewal and Differentiation of Isl1+ Cardiovascular Progenitors Are
Controlled by a Wnt/β-Catenin Pathway. Cell Stem Cell. 2007 Academic
Article GET IT
Times cited: 224
Reversine increases the plasticity of lineage-committed mammalian cells.
Proceedings of the National Academy of Sciences of the United States of
America. 2007 Academic Article GET IT
Times cited: 68
Genetic incorporation of unnatural amino acids into proteins in mammalian
cells. Nature Methods. 2007 Academic Article GET IT
Times cited: 231
Self-renewal of embryonic stem cells by a small molecule. Proceedings of
the National Academy of Sciences of the United States of America. 2006
Academic Article GET IT
Times cited: 221
Long-term self-renewal and directed differentiation of human embryonic stem
cells in chemically defined conditions. Proceedings of the National Academy
of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 331
Exploring stem cell biology with small molecules. Molecular BioSystems.
2006 Review GET IT
Times cited: 32
GSK-3 and Stem Cells. 2006 Chapter GET IT
Dedifferentiation of Lineage-Committed Cells by a Small Molecule. Journal
of the American Chemical Society. 2004 Academic Article GET IT
Times cited: 226
Orientation of the peptide formation of N-phosphoryl amino acids in solution
. Chinese Science Bulletin. 2002 Academic Article GET IT
Times cited: 3
Negative-ion electrospray ionization tandem mass spectrometry of N-
phosphoryl amino acids and dipeptides. Rapid Communications in Mass
Spectrometry. 2002 Academic Article GET IT
Times cited: 13
The Fmoc-Strategy Solid-Phase Synthesis of O-Phosphopeptide. Gaodeng
Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities. 2001
Academic Article
The study of phosphoramidite as O-phosphitylation agent and its reactivity.
Phosphorus, Sulfur and Silicon and Related Elements. 2000 Academic Article
Times cited: 8

c*62018-03-04 08:03

10 楼

确实好多文章都只是被综述引用过,没有同行的reproduce.
总之感觉这篇Cell Stem Cell的结果怪怪的.

Candidates
.

【在 b*********e 的大作中提到】

: 读了一下这篇文章，不喜欢这种研究思路，不能够称之为科学。
: 该实验室主页上面所挂出来的以下一些文章中，有很多引用率非常的低。
: ROCKII inhibition promotes the maturation of human pancreatic beta-like
: cells. Nature Communications. 2017 Academic Article GET IT
: High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates
: that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain.
: Cell Stem Cell. 2017 Academic Article GET IT
: A Modular Platform for Differentiation of Human PSCs into All Major
: Ectodermal Lineages. Cell Stem Cell. 2017 Academic Article GET IT
: An Integrated Systems Biology Approach Identifies TRIM25 as a Key