有可能是主要贡献吗? A challenge in photodynamic therapy (PDT) cancer treatment is developing novel methods of singlet oxygen generation using near infrared light. Titanium dioxide is a photocatalyst that generates reactive oxygen species (ROS), but it requires ultraviolet light. Lead sulfide (PbS) quantum dots have a narrow band gap, allowing them to tune the absorbed wavelengths of the nanotubes to the near infrared. To ensure singlet oxygen generation, the photoreactive NO donor S-nitroso-cysteine was also bound to the nanotubes, since reaction of NO with ROS forms singlet oxygen. The nanotubes were prepared using hydrothermal synthesis, and PbS quantum dots were attached using a thiolactic acid linker , which controls both the size of the quantum dots and the light wavelengths absorbed. The absorption spectrum and PbS band gap were measured using UV- Visible Spectroscopy, and PbS attachment was verified using Fourier transform infrared spectroscopy, x-ray diffraction and transmission electron microscopy. Next, l-cysteine was attached to the quantum dot doped nanotubes, and NO infusion led to S-nitroso-cysteine formation. The sample was irradiated in a Ray-Sorb flask (filtering wavelengths < 600 nm) using a mercury lamp while bubbling argon to collect NO in a vial of de-ionized water. The collected samples were analyzed using UV-Visible Spectroscopy, and nitrite concentrations were calculated. The results indicate that in near-infrared light, electron transfer from PbS to the nanotubes results in NO release and successful singlet oxygen generation. This project’s original approach of attaching S-nitroso-cysteine to PbS quantum dot decorated titanium dioxide nanotubes shows promise as a next generation PDT photosensitizer.
这是15岁的amy chyao, who is from Williams High School, Plano, TX, 的abstract for the 2010 Intel International Science and Engineering Fair. She won the top prize of $75,000 Awards won at the 2010 ISEF*************** Honorable Mention Award - American Chemical Society Intel ISEF Best of Category Award of $5,000 for Top First Place Winner - Chemistry - Presented by Intel Gordon Moore Award $75,000 - The Gordon E. Moore Award Tuition Scholarship Award in the amount of $8,000 - Office of Naval Research on behalf of the United States Navy and Marine Corps UTC Stock with an approximate value of $2,000 - United Technologies Corporation
d*e
16 楼
他是男的
【在 a********y 的大作中提到】 : 女孩子不要这么直接 : 要嗲一点嘛
b*g
17 楼
Good enough for a high school student! I know nothing in my high school. The science and chemistry in the project is not too hard, and if all of the experiments are supervised by a senior graduate student, i think it is very possible and reasonable. But in fact, this material is far away from real medical application, since Pb is highly toxic, and the metabolic behavior of Pb is horrible in human body, it tends to accumulate in brain.
abstract the Research
【在 l**********c 的大作中提到】 : 这是15岁的amy chyao, who is from Williams High School, Plano, TX, 的abstract : for the 2010 Intel International Science and Engineering Fair. She won the : top prize of $75,000 : Awards won at the 2010 ISEF*************** : Honorable Mention Award - American Chemical Society : Intel ISEF Best of Category Award of $5,000 for Top First Place Winner - : Chemistry - Presented by Intel : Gordon Moore Award $75,000 - The Gordon E. Moore Award : Tuition Scholarship Award in the amount of $8,000 - Office of Naval Research : on behalf of the United States Navy and Marine Corps
【在 l**********c 的大作中提到】 : 有可能是主要贡献吗? : A challenge in photodynamic therapy (PDT) cancer treatment is developing : novel methods of singlet oxygen generation using near infrared light. : Titanium : dioxide is a photocatalyst that generates reactive oxygen species (ROS), but : it requires ultraviolet light. Lead sulfide (PbS) quantum dots have a : narrow band : gap, allowing them to tune the absorbed wavelengths of the nanotubes to the : near infrared. To ensure singlet oxygen generation, the photoreactive NO : donor