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Analytical terms for 'specificity' and 'sensitivity'
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Analytical terms for 'specificity' and 'sensitivity'# Chemistry - 化学
y*i
1 楼
大家好，本人对TAX不是非常懂，想请教一下各位一些问题。
我们一家去年12月份的时候拿到的绿卡。我们两个人去年大部分时间都在一个州（简称
A州）。
10月份之后，我老婆在另外州找到工作，搬去了另外州（B州），拿过一部分搬家费公
司帮忙搬家，我还继续在A州。
我在A州的时候也换过公司，公司给了RELOCATION FEE，好像是会什么和税有关，具体
我也不懂。实在是在税盲。
现在想问一些问题。
首先我们报税是否能还是以JOINT TAX RETURN吗，毕竟大部分时间都是一起的。此外，
RELOCATION FEE会体现在TAX RETURN税表上吗?
那如果还是可以JOINT TAX RETURN,联邦税和州税都还是JOINT TAX RETURN吗？但是她
一部分时间在B州。
此外这种情况下，大家建议是自己报税还是请人呢，或者是买软件报税呢，有啥好的软
件可以推荐的吗？
谢谢大家给予指点
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n*7
2 楼
avatar
l*o
3 楼
莲生大师今天也说了："知我罪我，唯春秋尔"。
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C*l
4 楼
WM下用在TP2上的，拜谢
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M*e
5 楼
Hello,
I have a quick question about the terms used in the field of analytical
chemistry. Any input is really appreciated.
We are trying to determine whether a patient has taken a certain drug (
compliance) by examining the existence of drug metabolite in patient's
plasma via mass spectrometry. To evaluate how accurately this MS procedure
predict patient's compliance, we treat MS as an assay and patient's
compliance as gold standard to calculate sensitivity and specificity. But
reviewers said 'sensitivity' and 'specificity' are not proper terms used in
this field. I just wonder if there are some other quantity/term to measure
the procedure performance in this case.
Thanks!
avatar
z*n
6 楼
你还一根根数了？

【在 n****7 的大作中提到】

avatar
l*o
7 楼
同时，还吃“美女”。
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s*8
8 楼
snsitivity and specificity more analytical chemistry term. what is the
question?

in

【在 M****e 的大作中提到】
: Hello,
: I have a quick question about the terms used in the field of analytical
: chemistry. Any input is really appreciated.
: We are trying to determine whether a patient has taken a certain drug (
: compliance) by examining the existence of drug metabolite in patient's
: plasma via mass spectrometry. To evaluate how accurately this MS procedure
: predict patient's compliance, we treat MS as an assay and patient's
: compliance as gold standard to calculate sensitivity and specificity. But
: reviewers said 'sensitivity' and 'specificity' are not proper terms used in
: this field. I just wonder if there are some other quantity/term to measure
avatar
y*l
9 楼
估计就是夸张的。不排除有新农民真的会数。
比如我们家猪头，第一次收黄瓜种子趴那儿一个个数清楚了。
avatar
t*n
10 楼
这些文革余孽早晚被踏上许多只香港脚

同时，还吃“美女”。

【在 l*****o 的大作中提到】
: 同时，还吃“美女”。
avatar
M*e
11 楼
Thanks!
It's a manuscript "An LC-MS assay for the semi-quantitative screening of
cardiovascular medications in human serum", submitted to Journal of
Chromatography A.
One of the reviewers gave the comments:
If the manuscript should be published in an analytical journal some
modifications have to be done. Sensitivity, specificity and accuracy are not
used as typical in analytical terms. Please rephrase.
I'm clueless about what the reviewer meant to say.

【在 s**********8 的大作中提到】
: snsitivity and specificity more analytical chemistry term. what is the
: question?
:
: in
avatar
n*7
12 楼
一个坑１００粒种子， 一共１１个坑

【在 z*********n 的大作中提到】
: 你还一根根数了？
avatar
c*i
13 楼
这个“知我罪我”最近看到不少次。
会不会宁缺来一句“不向霸王让三分”？
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s*8
14 楼
tell him this is wrong. he seems not an expert in the area.
go get several just publish paper in that paper which use these terms.
go find FDA guidance for industry for bioanalytical method validation, use
it as reference

not

【在 M****e 的大作中提到】
: Thanks!
: It's a manuscript "An LC-MS assay for the semi-quantitative screening of
: cardiovascular medications in human serum", submitted to Journal of
: Chromatography A.
: One of the reviewers gave the comments:
: If the manuscript should be published in an analytical journal some
: modifications have to be done. Sensitivity, specificity and accuracy are not
: used as typical in analytical terms. Please rephrase.
: I'm clueless about what the reviewer meant to say.
avatar
z*n
15 楼
发芽率100%？

【在 n****7 的大作中提到】
: 一个坑１００粒种子， 一共１１个坑
avatar
d*0
16 楼
上有所好，下必胜焉
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s*8
17 楼
i mean in that journal.

use

【在 s**********8 的大作中提到】
: tell him this is wrong. he seems not an expert in the area.
: go get several just publish paper in that paper which use these terms.
: go find FDA guidance for industry for bioanalytical method validation, use
: it as reference
:
: not
avatar
n*7
18 楼
俺是新农民 :)

【在 y**l 的大作中提到】
: 估计就是夸张的。不排除有新农民真的会数。
: 比如我们家猪头，第一次收黄瓜种子趴那儿一个个数清楚了。
avatar
M*e
19 楼
Sounds good. Many thanks!

use

【在 s**********8 的大作中提到】
: tell him this is wrong. he seems not an expert in the area.
: go get several just publish paper in that paper which use these terms.
: go find FDA guidance for industry for bioanalytical method validation, use
: it as reference
:
: not
avatar
g*o
20 楼
怎么算的？

【在 z*********n 的大作中提到】
: 发芽率100%？
avatar
s*8
21 楼
also, complain to the responsive editor for pick the wrong reviewer.
if he/she denies, complain to chief editor.

【在 M****e 的大作中提到】
: Sounds good. Many thanks!
:
: use
avatar
n*7
22 楼
90%

【在 z*********n 的大作中提到】
: 发芽率100%？
avatar
S*x
23 楼
en, 2001 Bioanalytical Guidance

use

【在 s**********8 的大作中提到】
: tell him this is wrong. he seems not an expert in the area.
: go get several just publish paper in that paper which use these terms.
: go find FDA guidance for industry for bioanalytical method validation, use
: it as reference
:
: not
avatar
y*l
24 楼
可以理解，我也是新的。但是板上学了很多东西，现在收成比邻居种了7年的还要好

【在 n****7 的大作中提到】
: 俺是新农民 :)
avatar
t*t
25 楼
In your case, sensitivity is the ability of your assay to tell "positive"
from "negative" and specificity is the confidence you have on your "positive
" to be a "true positive". Explain it to the reviewers if they do not
understand.

in

【在 M****e 的大作中提到】
: Hello,
: I have a quick question about the terms used in the field of analytical
: chemistry. Any input is really appreciated.
: We are trying to determine whether a patient has taken a certain drug (
: compliance) by examining the existence of drug metabolite in patient's
: plasma via mass spectrometry. To evaluate how accurately this MS procedure
: predict patient's compliance, we treat MS as an assay and patient's
: compliance as gold standard to calculate sensitivity and specificity. But
: reviewers said 'sensitivity' and 'specificity' are not proper terms used in
: this field. I just wonder if there are some other quantity/term to measure
avatar
c*p
26 楼
觉得没有1000， 大概723
avatar
M*e
27 楼
Haha, will consider this resort...

【在 s**********8 的大作中提到】
: also, complain to the responsive editor for pick the wrong reviewer.
: if he/she denies, complain to chief editor.
avatar
z*n
28 楼
他没说有没有100%收割

【在 g*********o 的大作中提到】
: 怎么算的？
avatar
M*e
29 楼
Super! Thanks!

【在 S***x 的大作中提到】
: en, 2001 Bioanalytical Guidance
:
: use
avatar
c*p
30 楼
老三，你的签名咋也看不到了？

【在 z*********n 的大作中提到】
: 他没说有没有100%收割
avatar
M*e
31 楼
Yeah, definitely need add more words to explain 'sensitivity' and '
specificity' themselves. Even the definitions from Wikipedia will do the
work. Thanks for the nice suggestion!

positive

【在 t******t 的大作中提到】
: In your case, sensitivity is the ability of your assay to tell "positive"
: from "negative" and specificity is the confidence you have on your "positive
: " to be a "true positive". Explain it to the reviewers if they do not
: understand.
:
: in
avatar
g*o
32 楼
那他说什么个收割率了？

【在 z*********n 的大作中提到】
: 他没说有没有100%收割
avatar
m*2
33 楼
Maybe this reviewer prefers to use LOL to depict sensitivity, selectivity
replace specificity,SD instead of accuracy?
not sure, but just a guess.

not

【在 M****e 的大作中提到】
: Thanks!
: It's a manuscript "An LC-MS assay for the semi-quantitative screening of
: cardiovascular medications in human serum", submitted to Journal of
: Chromatography A.
: One of the reviewers gave the comments:
: If the manuscript should be published in an analytical journal some
: modifications have to be done. Sensitivity, specificity and accuracy are not
: used as typical in analytical terms. Please rephrase.
: I'm clueless about what the reviewer meant to say.
avatar
z*n
34 楼
你眼花了？

【在 c***p 的大作中提到】
: 老三，你的签名咋也看不到了？
avatar
M*e
35 楼
Thanks. May I ask what LOL stands for?

【在 m**********2 的大作中提到】
: Maybe this reviewer prefers to use LOL to depict sensitivity, selectivity
: replace specificity,SD instead of accuracy?
: not sure, but just a guess.
:
: not
avatar
n*7
36 楼
牛~~~

【在 y**l 的大作中提到】
: 可以理解，我也是新的。但是板上学了很多东西，现在收成比邻居种了7年的还要好
avatar
y*s
37 楼
LOL=laugh out loud...
LOD=limit of detection
avatar
y*l
38 楼
换了？ 宝宝树？
辞职当保姆了？

【在 z*********n 的大作中提到】
: 你眼花了？
avatar
t*n
39 楼
你是不是用了这几个词，但是用错了？

not

【在 M****e 的大作中提到】
: Thanks!
: It's a manuscript "An LC-MS assay for the semi-quantitative screening of
: cardiovascular medications in human serum", submitted to Journal of
: Chromatography A.
: One of the reviewers gave the comments:
: If the manuscript should be published in an analytical journal some
: modifications have to be done. Sensitivity, specificity and accuracy are not
: used as typical in analytical terms. Please rephrase.
: I'm clueless about what the reviewer meant to say.
avatar
n*7
40 楼
哈哈， 你说多少就多少

【在 c***p 的大作中提到】
: 觉得没有1000， 大概723
avatar
t*h
41 楼
this sounds correct. BTW, not LOL, should be LOD, limit of detection.
Sensitivity and specificiy have very different defination in othet fields.
especially, you were talking about patients, should check out the exact
definitation in medical statistics. google ROC curve.
In the field of sensor, transducer and signal processing, sensitivity is
defined as the first derivative of the transfer function (output readout vs
input signal).

【在 m**********2 的大作中提到】
: Maybe this reviewer prefers to use LOL to depict sensitivity, selectivity
: replace specificity,SD instead of accuracy?
: not sure, but just a guess.
:
: not
avatar
n*7
42 楼
俺也看不到了

【在 c***p 的大作中提到】
: 老三，你的签名咋也看不到了？
avatar
M*e
43 楼
Right. Just checked Bioanalytical Method Validation Guidance for Industry.
They use sensitivity/selectivity/accuracy to refer to different measurements
...

【在 t**n 的大作中提到】
: 你是不是用了这几个词，但是用错了？
:
: not
avatar
z*n
44 楼
奇怪

【在 n****7 的大作中提到】
: 俺也看不到了
avatar
M*e
45 楼
I think this is the point. We certainly use these terms as statistical
measures of performance, and we mentioned this in Statistical Analysis part.
I guess I need to somehow highlight the definitions... Thanks!

vs

【在 t*******h 的大作中提到】
: this sounds correct. BTW, not LOL, should be LOD, limit of detection.
: Sensitivity and specificiy have very different defination in othet fields.
: especially, you were talking about patients, should check out the exact
: definitation in medical statistics. google ROC curve.
: In the field of sensor, transducer and signal processing, sensitivity is
: defined as the first derivative of the transfer function (output readout vs
: input signal).
avatar
n*7
46 楼
全割了

【在 g*********o 的大作中提到】
: 那他说什么个收割率了？
avatar
p*g
47 楼
这两个是method validation里的,你有做这个吗?
不然就LOD/LOQ?

in

【在 M****e 的大作中提到】
: Hello,
: I have a quick question about the terms used in the field of analytical
: chemistry. Any input is really appreciated.
: We are trying to determine whether a patient has taken a certain drug (
: compliance) by examining the existence of drug metabolite in patient's
: plasma via mass spectrometry. To evaluate how accurately this MS procedure
: predict patient's compliance, we treat MS as an assay and patient's
: compliance as gold standard to calculate sensitivity and specificity. But
: reviewers said 'sensitivity' and 'specificity' are not proper terms used in
: this field. I just wonder if there are some other quantity/term to measure
avatar
g*o
48 楼
是看不到了，刚才还是宝宝树，现在又成限百度内部交流了

【在 z*********n 的大作中提到】
: 奇怪
avatar
e*e
49 楼
RE，楼主用的的和典型的分析术语有一点区别，偏向于流行病学和生物标志物领域，
reviewer可能是这个意思，觉得会让人误解

positive

【在 t******t 的大作中提到】
: In your case, sensitivity is the ability of your assay to tell "positive"
: from "negative" and specificity is the confidence you have on your "positive
: " to be a "true positive". Explain it to the reviewers if they do not
: understand.
:
: in
avatar
y*l
50 楼
en,
avatar
z*n
51 楼
这事闹的

【在 y**l 的大作中提到】
: en,
avatar
c*p
52 楼
我平衡了
不是唯一一个被整的

【在 z*********n 的大作中提到】
: 这事闹的
avatar
y*l
53 楼
en,老邢找到新玩具了。

【在 c***p 的大作中提到】
: 我平衡了
: 不是唯一一个被整的
avatar
P8
54 楼
zan

【在 n****7 的大作中提到】
: 全割了
avatar
a*s
55 楼
LOL
我的韭菜还是那么细，怎么办呀
avatar
y*l
56 楼
多剪剪就好了。

【在 a****s 的大作中提到】
: LOL
: 我的韭菜还是那么细，怎么办呀
avatar
u*e
57 楼
你数过？
avatar
a*s
58 楼
好的，谢谢！
很久没剪了，下不了手，因为仅存一小撮了，哈哈，有点种啥死啥的感觉

【在 y**l 的大作中提到】
: 多剪剪就好了。
avatar
l*t
59 楼
从种子种出来的? 真不容易!
avatar
y*l
60 楼
必须要剪的。 我也种了2盆，开始细溜溜的像头发丝，现在剪了几次粗了点儿。

【在 a****s 的大作中提到】
: 好的，谢谢！
: 很久没剪了，下不了手，因为仅存一小撮了，哈哈，有点种啥死啥的感觉
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