c*o
2 楼
我可以把你推荐给editor,感兴趣的话,尽快PM我。
你需要把你的简单背景发给我, 包括名字,email,现在的organization和title。 还
要在这个journal的reviewer database注册一下。
Title: Thermally induced degradation pathways of three different antibody-
based drug development candidates
European Journal of Pharmaceutical Sciences
ABSTRACT:
Protein-based medicinal products are prone to undergo a variety of chemical
and physical degradation pathways. One of the most important exogenous
stress condition to consider during manufacturing, transport and storage
processes is temperature, because antibody-based therapeutics are only
stable in a limited temperature range.
In this study, three different formats of antibody-based molecules (IgG1, a
bispecific scFv and a fab fragment) were exposed to thermal stress
conditions occurring during transport and storage. For evaluation, an
analytical platform was developed for the detection and characterization of
relevant degradation pathways of different antibody-based therapeutics. The
effect of thermal stress conditions on the stability of the three antibody-
based formats was therefore investigated using visual inspection, different
spectroscopic measurements, dynamic light scattering (DLS), differential
scanning calorimetry (DSC), electrophoresis, asymmetric flow field-flow
fractionation (AF4) and surface plasmon resonance technology (SPR).
In summary, thermal stress led to heterogeneous chemical and physical
degradation pathways of all three antibody-based formats used. In addition,
identical exogenous stress conditions resulted in different kinds and levels
of aggregates and fragmentation products. This knowledge is an essential
base for a systematic and successful stabilization of protein-based
therapeutics by the use of formulation additives.
你需要把你的简单背景发给我, 包括名字,email,现在的organization和title。 还
要在这个journal的reviewer database注册一下。
Title: Thermally induced degradation pathways of three different antibody-
based drug development candidates
European Journal of Pharmaceutical Sciences
ABSTRACT:
Protein-based medicinal products are prone to undergo a variety of chemical
and physical degradation pathways. One of the most important exogenous
stress condition to consider during manufacturing, transport and storage
processes is temperature, because antibody-based therapeutics are only
stable in a limited temperature range.
In this study, three different formats of antibody-based molecules (IgG1, a
bispecific scFv and a fab fragment) were exposed to thermal stress
conditions occurring during transport and storage. For evaluation, an
analytical platform was developed for the detection and characterization of
relevant degradation pathways of different antibody-based therapeutics. The
effect of thermal stress conditions on the stability of the three antibody-
based formats was therefore investigated using visual inspection, different
spectroscopic measurements, dynamic light scattering (DLS), differential
scanning calorimetry (DSC), electrophoresis, asymmetric flow field-flow
fractionation (AF4) and surface plasmon resonance technology (SPR).
In summary, thermal stress led to heterogeneous chemical and physical
degradation pathways of all three antibody-based formats used. In addition,
identical exogenous stress conditions resulted in different kinds and levels
of aggregates and fragmentation products. This knowledge is an essential
base for a systematic and successful stabilization of protein-based
therapeutics by the use of formulation additives.
y*g
3 楼
大农村。两个一样户型的两层townhouse都是1200sqft。其中一个有unfinished
basement,walk-out那种,大概就是600sqft那么大。请问这个basement能给房价增值多
少?
虽然房价本来就低,不过几千一万也是钱。求大家估价,谢谢。
basement,walk-out那种,大概就是600sqft那么大。请问这个basement能给房价增值多
少?
虽然房价本来就低,不过几千一万也是钱。求大家估价,谢谢。
c*d
4 楼
哎,怕KS的红包玛丽安太大没进,心草难除阿。
JM们帮忙看一下这几个红色鸭子包包,1 (11x10x6.5)是新款,要贵一倍。2和1差不多
大,3是(14x10x5.5),没找到红色图。
JM们帮忙看一下这几个红色鸭子包包,1 (11x10x6.5)是新款,要贵一倍。2和1差不多
大,3是(14x10x5.5),没找到红色图。
h*y
5 楼
同在等,但是希望应该很渺茫了
S*n
6 楼
your mailbox is full...can you give me your personal email?
I have a Ph.D of Pharmaceutical Sciences. This is in my field.
Postdoc fellow at UCSF
Please recommend me to the editor.
Thanks a lot!
chemical
【在 c*********o 的大作中提到】
: 我可以把你推荐给editor,感兴趣的话,尽快PM我。
: 你需要把你的简单背景发给我, 包括名字,email,现在的organization和title。 还
: 要在这个journal的reviewer database注册一下。
: Title: Thermally induced degradation pathways of three different antibody-
: based drug development candidates
: European Journal of Pharmaceutical Sciences
: ABSTRACT:
: Protein-based medicinal products are prone to undergo a variety of chemical
: and physical degradation pathways. One of the most important exogenous
: stress condition to consider during manufacturing, transport and storage
I have a Ph.D of Pharmaceutical Sciences. This is in my field.
Postdoc fellow at UCSF
Please recommend me to the editor.
Thanks a lot!
chemical
【在 c*********o 的大作中提到】
: 我可以把你推荐给editor,感兴趣的话,尽快PM我。
: 你需要把你的简单背景发给我, 包括名字,email,现在的organization和title。 还
: 要在这个journal的reviewer database注册一下。
: Title: Thermally induced degradation pathways of three different antibody-
: based drug development candidates
: European Journal of Pharmaceutical Sciences
: ABSTRACT:
: Protein-based medicinal products are prone to undergo a variety of chemical
: and physical degradation pathways. One of the most important exogenous
: stress condition to consider during manufacturing, transport and storage
y*g
7 楼
踢一脚。这里没有来自大农村的大牛么。。。都是加州的?
o*n
8 楼
3,有点爱马士包包的感觉。
c*o
10 楼
c*********[email protected]
【在 S********n 的大作中提到】
: your mailbox is full...can you give me your personal email?
: I have a Ph.D of Pharmaceutical Sciences. This is in my field.
: Postdoc fellow at UCSF
: Please recommend me to the editor.
: Thanks a lot!
:
: chemical
【在 S********n 的大作中提到】
: your mailbox is full...can you give me your personal email?
: I have a Ph.D of Pharmaceutical Sciences. This is in my field.
: Postdoc fellow at UCSF
: Please recommend me to the editor.
: Thanks a lot!
:
: chemical
h*e
12 楼
我喜欢 :)
两个都喜欢!!!
鸭子包包有的时候是打折的,不过不知道现在有木有啊!!!
两个都喜欢!!!
鸭子包包有的时候是打折的,不过不知道现在有木有啊!!!
j*o
13 楼
非pp应该还能挣扎到5月底
S*n
14 楼
just sent, thanks!
【在 c*********o 的大作中提到】
: c*********[email protected]
【在 c*********o 的大作中提到】
: c*********[email protected]
m*3
15 楼
你这问题俺们也没法儿回答啊,你得看你们那旮瘩的类似房子的售价才行。另外实在看
不明白你到底在问啥,你还得考虑年代,社区,学区,交通,等等很多方面,所以还是
上 redfin 啥的自己查比较靠谱。
不明白你到底在问啥,你还得考虑年代,社区,学区,交通,等等很多方面,所以还是
上 redfin 啥的自己查比较靠谱。
y*g
18 楼
哎,我是真不清楚才上来问的。
就是基本同一片小区,左边一排有basement,右边一排没有,其他都是一样的。左边那
排一个有unfinished basement的刚卖了12万。我想知道右边那个没basement我应该出
价多少。假设内装修什么的也一样。
我觉得redfin上我看半天也没感觉啊。每个房子卖的年份不一样,找个少几千,那个多
几千。真是搞不清一个unfinished basement到底值多少钱。
就是基本同一片小区,左边一排有basement,右边一排没有,其他都是一样的。左边那
排一个有unfinished basement的刚卖了12万。我想知道右边那个没basement我应该出
价多少。假设内装修什么的也一样。
我觉得redfin上我看半天也没感觉啊。每个房子卖的年份不一样,找个少几千,那个多
几千。真是搞不清一个unfinished basement到底值多少钱。
D*1
19 楼
爱最后一个 求连接
m*3
21 楼
这个真不好说,不过你可以试试这个看行不:既然那个房子刚卖了12万,那你查一下你
们 county 的 property record,比一下这两个房子再加上街上别的类似房子的
assessment value,然后按比例算一下就差不多了,当然内部装修啥的没办法比。
那排一个有unfinished basement的刚卖了12万。我想知道右边那个没basement我应该
出价多少。假设内装修什么的也一样。
多几千。真是搞不清一个unfinished basement到底值多少钱。
【在 y*****g 的大作中提到】
: 哎,我是真不清楚才上来问的。
: 就是基本同一片小区,左边一排有basement,右边一排没有,其他都是一样的。左边那
: 排一个有unfinished basement的刚卖了12万。我想知道右边那个没basement我应该出
: 价多少。假设内装修什么的也一样。
: 我觉得redfin上我看半天也没感觉啊。每个房子卖的年份不一样,找个少几千,那个多
: 几千。真是搞不清一个unfinished basement到底值多少钱。
们 county 的 property record,比一下这两个房子再加上街上别的类似房子的
assessment value,然后按比例算一下就差不多了,当然内部装修啥的没办法比。
那排一个有unfinished basement的刚卖了12万。我想知道右边那个没basement我应该
出价多少。假设内装修什么的也一样。
多几千。真是搞不清一个unfinished basement到底值多少钱。
【在 y*****g 的大作中提到】
: 哎,我是真不清楚才上来问的。
: 就是基本同一片小区,左边一排有basement,右边一排没有,其他都是一样的。左边那
: 排一个有unfinished basement的刚卖了12万。我想知道右边那个没basement我应该出
: 价多少。假设内装修什么的也一样。
: 我觉得redfin上我看半天也没感觉啊。每个房子卖的年份不一样,找个少几千,那个多
: 几千。真是搞不清一个unfinished basement到底值多少钱。
b*l
22 楼
最后一个很漂亮!!第一个跟第二个差不多,也挺好看的。
N*d
24 楼
不是大农村,大农村不会有连动物
h*t
25 楼
3.有红或桔色的吗.
y*g
26 楼
谢谢!我去查查!
c*l
29 楼
玛丽安一看就是30-40岁的人背的
鸭子包50-60岁人拿的多
鸭子包50-60岁人拿的多
S*I
31 楼
要紅的就第一個。可背可垮。第三個很正式。
從前鴨子包的質量太好,用不壞,用不舊是一大缺點。
從前鴨子包的質量太好,用不壞,用不舊是一大缺點。
G*e
35 楼
这是什么牌子啊,包多少钱啊
k*x
37 楼
3
L*e
39 楼
最后一个好看!
l*g
40 楼
like the last one.
w*p
41 楼
3好看
w*e
42 楼
乍一看以为1,2一样的呢,都挺好看的
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