H*g
2 楼
【 以下文字转载自 Biology 讨论区 】
发信人: freewang (Tom), 信区: Biology
标 题: 爸爸早年受点苦，孩子会得福
发信站: BBS 未名空间站 (Wed Nov 19 07:50:57 2014, 美东)
Early life stress in fathers improves behavioural flexibility in their
offspring
Nature Comm.
Traumatic experiences in childhood can alter behavioural responses and
increase the risk for psychopathologies across life, not only in the exposed
individuals but also in their progeny. In some conditions, such experiences
can however be beneficial and facilitate the appraisal of adverse
environments later in life. Here we expose newborn mice to unpredictable
maternal separation combined with unpredictable maternal stress (MSUS) for 2
weeks and assess the impact on behaviour in the offspring when adult. We
show that MSUS in male mice favours goal-directed behaviours and behavioural
flexibility in the adult offspring. This effect is accompanied by
epigenetic changes involving histone post-translational modifications at the
mineralocorticoid receptor (MR) gene and decreased MR
expression in the hippocampus. Mimicking these changes pharmacologically in
vivo reproduces the behavioural phenotype. These findings highlight the
beneficial impact that early adverse experiences can have in adulthood, and
the implication of epigenetic modes of gene regulation.
发信人: freewang (Tom), 信区: Biology
标 题: 爸爸早年受点苦，孩子会得福
发信站: BBS 未名空间站 (Wed Nov 19 07:50:57 2014, 美东)
Early life stress in fathers improves behavioural flexibility in their
offspring
Nature Comm.
Traumatic experiences in childhood can alter behavioural responses and
increase the risk for psychopathologies across life, not only in the exposed
individuals but also in their progeny. In some conditions, such experiences
can however be beneficial and facilitate the appraisal of adverse
environments later in life. Here we expose newborn mice to unpredictable
maternal separation combined with unpredictable maternal stress (MSUS) for 2
weeks and assess the impact on behaviour in the offspring when adult. We
show that MSUS in male mice favours goal-directed behaviours and behavioural
flexibility in the adult offspring. This effect is accompanied by
epigenetic changes involving histone post-translational modifications at the
mineralocorticoid receptor (MR) gene and decreased MR
expression in the hippocampus. Mimicking these changes pharmacologically in
vivo reproduces the behavioural phenotype. These findings highlight the
beneficial impact that early adverse experiences can have in adulthood, and
the implication of epigenetic modes of gene regulation.
b*e
3 楼
看完了不还得吃饭。
l*t
4 楼
这算坑爹么
a*u
5 楼
不明白为什么在井下呆了69天，出来还是鲜灵活跳的，有的连胡子都不长， 都像是昨
天刚下井的
天刚下井的
d*a
6 楼
三一厉害。
那起重机就是他家造的
【在 s*k 的大作中提到】
: 真觉得生命才是至高无上的，比操这JB股票重要多了
那起重机就是他家造的
【在 s*k 的大作中提到】
: 真觉得生命才是至高无上的，比操这JB股票重要多了
p*8
7 楼
之前打了管道, 输送食物及日用品.
这些矿工获救后可以退休了,
补偿金和卖故事, 比中国的苦哈哈矿工强太多了
这些矿工获救后可以退休了,
补偿金和卖故事, 比中国的苦哈哈矿工强太多了
Y*r
8 楼
sigh.........
x*z
9 楼
agree, nothing is more important than life.
M*0
10 楼
比起那个钻井的如何？ 钻井设备由CENTER ROCK INC， 老总高中毕业。
【在 d********a 的大作中提到】
: 三一厉害。
: 那起重机就是他家造的
【在 d********a 的大作中提到】
: 三一厉害。
: 那起重机就是他家造的
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