昨天在 Barnes and nobles 看 playboy# Joke - 肚皮舞运动
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Entitled "Asymptomatic bacteriuria increases the risk of edematous attacks
in hereditary angioedema due to C1-inhibitor deficiency"
Article Type: Original Article
Background: Although urinary tract infections are considered among the most
common infectious disorders in humans, these usually follow an uncomplicated
course. Various infections may have a role in inducing HAE attacks. Further
, danazol treatment has been associated with hematuria.
Objective: Our study intended to evaluate the abnormalities of the
urinalysis of C1-INH-HAE patients.
Methods: Urine specimens contributed by 139 C1-INH-HAE patients at the
annual control visits were studied retrospectively (RBC and WBC counts,
microorganisms). We analyzed these laboratory parameters in relation of the
clinical symptoms and in view of long-term danazol therapy.
Results: Taking into account 3 randomly selected urine specimens, we found
that the cumulative number of edematous attacks was higher in patients with
than in those without bacteriuria (p=0.019, p=0.022, p=0.014). Considering
the same patients (n=76), attack number was significantly higher (14.51 vs.
8.63) in patients with than in those without bacteriuria (p<0.0001). The
cumulative incidence of microhematuria found upon a single or repeated
examination was 74.8% after the annual check-up per patient. Taking into
account an observation period of 3 years, the alterations detected in the
urinary sediment were unrelated to treatment with or the dose of danazol.
Conclusion: The cumulative incidence of microhematuria was substantially
higher compared with the historical data of healthy individuals. As regards
the background of this phenomenon, we did not found any relationship with
danazol therapy. The main finding of our study was that the increased
incidence of edema was associated with bacteriuria. This finding emphasizes
the triggering role of bacteriuria in the occurrence of edematous episodes.
你的
(1)简短的PUBLICATION LIST 不超过5篇文章
(2)你的名字
(3)学位
(4)EMAIL地址
Entitled "Asymptomatic bacteriuria increases the risk of edematous attacks
in hereditary angioedema due to C1-inhibitor deficiency"
Article Type: Original Article
Background: Although urinary tract infections are considered among the most
common infectious disorders in humans, these usually follow an uncomplicated
course. Various infections may have a role in inducing HAE attacks. Further
, danazol treatment has been associated with hematuria.
Objective: Our study intended to evaluate the abnormalities of the
urinalysis of C1-INH-HAE patients.
Methods: Urine specimens contributed by 139 C1-INH-HAE patients at the
annual control visits were studied retrospectively (RBC and WBC counts,
microorganisms). We analyzed these laboratory parameters in relation of the
clinical symptoms and in view of long-term danazol therapy.
Results: Taking into account 3 randomly selected urine specimens, we found
that the cumulative number of edematous attacks was higher in patients with
than in those without bacteriuria (p=0.019, p=0.022, p=0.014). Considering
the same patients (n=76), attack number was significantly higher (14.51 vs.
8.63) in patients with than in those without bacteriuria (p<0.0001). The
cumulative incidence of microhematuria found upon a single or repeated
examination was 74.8% after the annual check-up per patient. Taking into
account an observation period of 3 years, the alterations detected in the
urinary sediment were unrelated to treatment with or the dose of danazol.
Conclusion: The cumulative incidence of microhematuria was substantially
higher compared with the historical data of healthy individuals. As regards
the background of this phenomenon, we did not found any relationship with
danazol therapy. The main finding of our study was that the increased
incidence of edema was associated with bacteriuria. This finding emphasizes
the triggering role of bacteriuria in the occurrence of edematous episodes.