嘉宾公布 | 清华大学尹航教授受邀出席2023（第七届）细胞外囊泡前沿与转化大会

Membrane curvature and lipid composition sensors targeting extracellular   vesicle Abstract Body: An emerging cancer metastasis   biomarker that possesses tremendous potential is the exosomes and   microvesicles secreted by cancerous cells. However, the secretion of exosomes   and microvesicles cannot be monitored using traditional detection methods due   to their small sizes. We developed an innovative strategy to detect and   target various metastatic cancers using rationally designed peptide probes   that recognize highly curved surface of exosomes and microvesicles. These   peptide probes also render novel tools to selectively target cancer cells   with specific lipid compositions and distributions. Taking advantage of these   tools, we discovered new relationship between extracellular vesicles and   cellular physiological process. Recently we found transport of ODN and Cdc42   from TLR9-activated macrophages to naïve cells via extracellular vesicles   exerts synergetic effects in propagation of the intracellular immune   response, suggesting a general mechanism of EV-mediated uptake of   pathogen-associated molecular patterns.   

尹航 教授

清华大学药学院

17321098232（微信同号）

会议推荐

RECOMMENDATIONS

点击了解详情

点击了解详情