s*o
2 楼
我女儿目前就读于史岱文森高中，9年级学生，成绩很好，她想要找一份家教的工作，
可以辅导小学/中学的学生，地点可在曼哈顿/皇后地区，时间：周一到周四5：00 pm-7
:00 pm 或者周末。这是她想要给自己锻炼的机会，有需要的朋友请联系我（站内信）
或直接email给她也可（[email protected]
/* */)，谢谢！
可以辅导小学/中学的学生，地点可在曼哈顿/皇后地区，时间：周一到周四5：00 pm-7
:00 pm 或者周末。这是她想要给自己锻炼的机会，有需要的朋友请联系我（站内信）
或直接email给她也可（[email protected]
/* */)，谢谢！
c*i
3 楼
Peter Landers, New Breast Cancer Drug Found Deep in the Sea. Wall Street
Journal, Jan. 4, 2010.
http://online.wsj.com/article/SB1000142405274870411150457605977
("A study found it [Halaven] extended the life of patients with advanced
breast cancer by about two-and-1/2 months, to 13 months")
My comment:
(a) Eisai Co., Ltd. エーザイ株式会社
(a public company; headquarters Tokyo; established in 1941 by Toyoji NAITO
内藤 豊次 as Nohon Eisai Co., Ltd. 日本衛材（衛生材料の略。具体的には絆創膏
や包帯の事))
ja.wikipedia.org
(b) eribulin
http://en.wikipedia.org/wiki/Eribulin
(c) Yoshito KISHI 岸 義人, Department of Chemistry and Chemical Biology,
Harvard University.
http://www.chem.harvard.edu/research/faculty/yoshito_kishi.php
(d) Catharanthus
http://en.wikipedia.org/wiki/Catharanthus
(the genus name for Madagascar periwinkle)
Note: Madagascar periwinkle is an annual bedding plant we see everywhere in
US and Taiwan alike.
(i) vincristine
http://en.wikipedia.org/wiki/Vincristine
(approved by the United States Food and Drug Administration (FDA) in July
1963 as Oncovin)
Quote:
Vincristine is a vinca alkaloid from the Catharanthus roseus (Madagascar
periwinkle), formerly Vinca rosea and hence its name.
"Vincristine binds to tubulin dimers, inhibiting assembly of microtubule
structures. Disruption of the microtubules arrests mitosis in metaphase. The
vinca alkaloids therefore affect all rapidly dividing cell types including
cancer cells, but also intestinal epithelium and bone marrow.
(e) Mechanism of the Gleevec.
Most chronic myelogenous leukemia (CML) patients share a distinctive feature
described in 1960 by two scientists from Philadelphia. The reciprocal
translocation switches ends of chromosomes 9 and 22 with each other (the
resultant chromosome 22 is the Philadelphia chromosome). As a result, part
of the BCR ("breakpoint cluster region") gene from chromosome 22 is fused
with the ABL gene on chromosome 9.
The abl stands for "Abelson", the name of a leukemia VIRUS (in mouse) which
carries a similar protein whose gene the virus grabbed from a host in
ancient time to help itself proliferate. ABL (all upper cases) is the normal
counterpart in almost all living cells that performs vital functions--
basically an enzyme that can add a phosphate group to a certain tyrosine
residue of a tyrosine kinase, therefore activating that kinase. In
Philadelphia chromosome, the ABL portion of the fusion protein is stuck in a
perpetually active position, which somehow causes cancer. (Why? Nobody
knows.)
Gleevec specifically binds to, blocks and inactivates the ABL portion of the
fusion protein.
(f) Takashi OWA 大和 隆志 (東京大学大学院薬学系研究科博士)
(g)
(i) For ramamycine, see sirolimus
http://en.wikipedia.org/wiki/Sirolimus
(an immunosuppressant drug used to prevent rejection in organ
transplantation; was first discovered as a product of the bacterium
Streptomyces hygroscopicus in a soil sample from Easter Island — an island
also known as "Rapa Nui", hence the name)
(ii) The origin of "Rapa Rui" name:
http://www.netaxs.com/~trance/def.html
Compare
Rapa Iti
http://en.wikipedia.org/wiki/Rapa_Iti
Rapa Iti was originally called simply Rapa. Iti ("small" in the local
Polynesian language) was added to distinguish Rapa Rui, which was actually
named after Rapa (Iti).
(iii) mammalian target of rapamycin
http://en.wikipedia.org/wiki/Mammalian_target_of_rapamycin
(mTOR; a serine/threonine protein kinase)
A serine/threonine protein kinase is a (protein) kinase which is activated
by adding a phosphate to a certain serine or threonine of that kinase--as
opposed to tyrosine of a tyrosine kinase--and activate the kinase.
The serine, threonine and tyrosine are amino acids, components of a protein.
(h) Sidebar:
* Cinchona
http://en.wikipedia.org/wiki/Cinchona
(Carolus "Carl" Linnaeus named the tree in 1742 after a Countess of Chinchon
, the wife of a viceroy of Peru, who, in 1638, was introduced by natives to
the medicinal properties of the bark)
Translated as 金雞納樹 in Taiwan.
* Compare chemical structures of aspirin (acetylsalicylic acid chemically)
http://en.wikipedia.org/wiki/Aspirin
and
salicylic acid
http://en.wikipedia.org/wiki/Salicylic_acid
, and you will learn where the acetyl group (CH3-COO) is added to the latter.
* cyclosporin
http://en.wikipedia.org/wiki/Cyclosporin
(Initially isolated from the fungus Tolypocladium inflatum isolated from a
soil sample obtained by Sandoz scientists at Hardangervidda, Norway in 1969,
ciclosporin is a cyclic nonribosomal peptide of 11 amino acids)
Translated as 環孢靈. 環 (or cyclo- in English name), due to its "cyclic"
structre.
* exenatide
http://en.wikipedia.org/wiki/Exenatide
(marketed as Byetta; a synthetic version of exendin-4, a hormone found in
the saliva of the Gila monster that was first isolated by Dr. John Eng in
1992 while working at the Veterans Administration Medical Center in the
Bronx, New York; made up of 39 amino acids; injected subcutaneously)
John Eng MD, an endocrinologist, is Asian. His publication to report
discovery did not speculate about its function in the animal.
Eng J et al, Isolation and Characterizationo f Exendin-4, an Exendin-3
Analogue, from Heloderma suspecturn Venom; Further evidence for an exendin
receptor on dispersed acini from Guinea Pig Pancreas. J. Biol Chem
267: 7402-7405 (1992).
http://www.jbc.org/content/267/11/7402.full.pdf
Gila monster
http://en.wikipedia.org/wiki/Gila_monster
(native to the southwestern United States and northerwestern Mexico; A heavy
, slow-moving lizard, up to 60 centimetres (2.0 ft) long; The name Gila
refers to the Gila River Basin in Arizona, where they were once plentiful;
section 3.2 Venom)
What is the function of the hormone for Gila monster itself, as opposed to
humans? Nobody knows.
Journal, Jan. 4, 2010.
http://online.wsj.com/article/SB1000142405274870411150457605977
("A study found it [Halaven] extended the life of patients with advanced
breast cancer by about two-and-1/2 months, to 13 months")
My comment:
(a) Eisai Co., Ltd. エーザイ株式会社
(a public company; headquarters Tokyo; established in 1941 by Toyoji NAITO
内藤 豊次 as Nohon Eisai Co., Ltd. 日本衛材（衛生材料の略。具体的には絆創膏
や包帯の事))
ja.wikipedia.org
(b) eribulin
http://en.wikipedia.org/wiki/Eribulin
(c) Yoshito KISHI 岸 義人, Department of Chemistry and Chemical Biology,
Harvard University.
http://www.chem.harvard.edu/research/faculty/yoshito_kishi.php
(d) Catharanthus
http://en.wikipedia.org/wiki/Catharanthus
(the genus name for Madagascar periwinkle)
Note: Madagascar periwinkle is an annual bedding plant we see everywhere in
US and Taiwan alike.
(i) vincristine
http://en.wikipedia.org/wiki/Vincristine
(approved by the United States Food and Drug Administration (FDA) in July
1963 as Oncovin)
Quote:
Vincristine is a vinca alkaloid from the Catharanthus roseus (Madagascar
periwinkle), formerly Vinca rosea and hence its name.
"Vincristine binds to tubulin dimers, inhibiting assembly of microtubule
structures. Disruption of the microtubules arrests mitosis in metaphase. The
vinca alkaloids therefore affect all rapidly dividing cell types including
cancer cells, but also intestinal epithelium and bone marrow.
(e) Mechanism of the Gleevec.
Most chronic myelogenous leukemia (CML) patients share a distinctive feature
described in 1960 by two scientists from Philadelphia. The reciprocal
translocation switches ends of chromosomes 9 and 22 with each other (the
resultant chromosome 22 is the Philadelphia chromosome). As a result, part
of the BCR ("breakpoint cluster region") gene from chromosome 22 is fused
with the ABL gene on chromosome 9.
The abl stands for "Abelson", the name of a leukemia VIRUS (in mouse) which
carries a similar protein whose gene the virus grabbed from a host in
ancient time to help itself proliferate. ABL (all upper cases) is the normal
counterpart in almost all living cells that performs vital functions--
basically an enzyme that can add a phosphate group to a certain tyrosine
residue of a tyrosine kinase, therefore activating that kinase. In
Philadelphia chromosome, the ABL portion of the fusion protein is stuck in a
perpetually active position, which somehow causes cancer. (Why? Nobody
knows.)
Gleevec specifically binds to, blocks and inactivates the ABL portion of the
fusion protein.
(f) Takashi OWA 大和 隆志 (東京大学大学院薬学系研究科博士)
(g)
(i) For ramamycine, see sirolimus
http://en.wikipedia.org/wiki/Sirolimus
(an immunosuppressant drug used to prevent rejection in organ
transplantation; was first discovered as a product of the bacterium
Streptomyces hygroscopicus in a soil sample from Easter Island — an island
also known as "Rapa Nui", hence the name)
(ii) The origin of "Rapa Rui" name:
http://www.netaxs.com/~trance/def.html
Compare
Rapa Iti
http://en.wikipedia.org/wiki/Rapa_Iti
Rapa Iti was originally called simply Rapa. Iti ("small" in the local
Polynesian language) was added to distinguish Rapa Rui, which was actually
named after Rapa (Iti).
(iii) mammalian target of rapamycin
http://en.wikipedia.org/wiki/Mammalian_target_of_rapamycin
(mTOR; a serine/threonine protein kinase)
A serine/threonine protein kinase is a (protein) kinase which is activated
by adding a phosphate to a certain serine or threonine of that kinase--as
opposed to tyrosine of a tyrosine kinase--and activate the kinase.
The serine, threonine and tyrosine are amino acids, components of a protein.
(h) Sidebar:
* Cinchona
http://en.wikipedia.org/wiki/Cinchona
(Carolus "Carl" Linnaeus named the tree in 1742 after a Countess of Chinchon
, the wife of a viceroy of Peru, who, in 1638, was introduced by natives to
the medicinal properties of the bark)
Translated as 金雞納樹 in Taiwan.
* Compare chemical structures of aspirin (acetylsalicylic acid chemically)
http://en.wikipedia.org/wiki/Aspirin
and
salicylic acid
http://en.wikipedia.org/wiki/Salicylic_acid
, and you will learn where the acetyl group (CH3-COO) is added to the latter.
* cyclosporin
http://en.wikipedia.org/wiki/Cyclosporin
(Initially isolated from the fungus Tolypocladium inflatum isolated from a
soil sample obtained by Sandoz scientists at Hardangervidda, Norway in 1969,
ciclosporin is a cyclic nonribosomal peptide of 11 amino acids)
Translated as 環孢靈. 環 (or cyclo- in English name), due to its "cyclic"
structre.
* exenatide
http://en.wikipedia.org/wiki/Exenatide
(marketed as Byetta; a synthetic version of exendin-4, a hormone found in
the saliva of the Gila monster that was first isolated by Dr. John Eng in
1992 while working at the Veterans Administration Medical Center in the
Bronx, New York; made up of 39 amino acids; injected subcutaneously)
John Eng MD, an endocrinologist, is Asian. His publication to report
discovery did not speculate about its function in the animal.
Eng J et al, Isolation and Characterizationo f Exendin-4, an Exendin-3
Analogue, from Heloderma suspecturn Venom; Further evidence for an exendin
receptor on dispersed acini from Guinea Pig Pancreas. J. Biol Chem
267: 7402-7405 (1992).
http://www.jbc.org/content/267/11/7402.full.pdf
Gila monster
http://en.wikipedia.org/wiki/Gila_monster
(native to the southwestern United States and northerwestern Mexico; A heavy
, slow-moving lizard, up to 60 centimetres (2.0 ft) long; The name Gila
refers to the Gila River Basin in Arizona, where they were once plentiful;
section 3.2 Venom)
What is the function of the hormone for Gila monster itself, as opposed to
humans? Nobody knows.
l*g
4 楼
因为要用cash,去年从Roth IRA上取出$4000，这个钱要当作收入保税吗？
这个钱是税后存到Roth IRA上的，不应该再上税了。可是收到了Fedelity 寄来的1099R
。困惑中。。
这个钱是税后存到Roth IRA上的，不应该再上税了。可是收到了Fedelity 寄来的1099R
。困惑中。。
h*n
5 楼
韩国小朋友
Fingerstyle Guitarist
9岁开始弹吉他，应该是06年
现在12岁
06年就能弹得不错了
最早的视频之一，当时才学琴几个月？人还没有吉他大。。。
Fingerstyle Guitarist
9岁开始弹吉他，应该是06年
现在12岁
06年就能弹得不错了
最早的视频之一，当时才学琴几个月？人还没有吉他大。。。
f*g
6 楼
让步的男人，是最可交的男人。一个不懂得为亲人让步、为朋友让步、为女人让步、为合作伙伴让步的男人，是缺乏胸襟，最无能和最不可交的人。
长不大的男人最重要的标志：就是跟自己人，跟自己所爱的家人，无谓的争长短、论输赢。
那些看起来很爱面子的男人，其实是他们内心充满着不自信、充满着胆怯。那些装成硬汉、从不会认错和让步的男人，他们的内心往往充满着嫉妒和狭隘，阳光很难走进他们的心灵。
何谓成熟男人?对家人、对爱人，很温柔。温柔得***孩子、***女人。对外、对困难，毫无惧意，顶天立地，不慌不忙，淡定从容。
动不动就与亲人争执，寸土不让，哪怕口舌上的输赢都要争的男人，可以保证，他们在外面必定没什么作为。
当女人退一步，男人就要退两步。一个懂得爱的人，宁可扮演输家，也不会去打败自己的亲人、爱人和朋友。打败了她们，你能得到什么?又能证明什么?一个优秀的男人，是不会在自己心爱的人面前逞能、较劲、争长短。
爱：就是妥协，就是让步。让步不是退却，也不是从权，而是尊重不同的看法和意见，不要在自己喜欢和爱的人那里去争权威。
一个懂爱、懂让步的男人，是最可交的男人。原野文化可以让您改变命运！遇见了，就是你的福气，是一生的好运。
无论你有多么聪明，多么富有，多有权势，人愤怒的那一个瞬间，智商是零，过一分钟后恢复正常。
记住：千万不要愤怒的时候，做任何决策!
人的优雅关键在于控制自己情绪，用嘴伤害人，是最愚蠢的一种行为。我们的不自由，通常是因为来自内心的不良情绪左右了我们。
记住：一个能控制住不良情绪的人，比一个能拿下一座城的人更强大。
长不大的男人最重要的标志：就是跟自己人，跟自己所爱的家人，无谓的争长短、论输赢。
那些看起来很爱面子的男人，其实是他们内心充满着不自信、充满着胆怯。那些装成硬汉、从不会认错和让步的男人，他们的内心往往充满着嫉妒和狭隘，阳光很难走进他们的心灵。
何谓成熟男人?对家人、对爱人，很温柔。温柔得***孩子、***女人。对外、对困难，毫无惧意，顶天立地，不慌不忙，淡定从容。
动不动就与亲人争执，寸土不让，哪怕口舌上的输赢都要争的男人，可以保证，他们在外面必定没什么作为。
当女人退一步，男人就要退两步。一个懂得爱的人，宁可扮演输家，也不会去打败自己的亲人、爱人和朋友。打败了她们，你能得到什么?又能证明什么?一个优秀的男人，是不会在自己心爱的人面前逞能、较劲、争长短。
爱：就是妥协，就是让步。让步不是退却，也不是从权，而是尊重不同的看法和意见，不要在自己喜欢和爱的人那里去争权威。
一个懂爱、懂让步的男人，是最可交的男人。原野文化可以让您改变命运！遇见了，就是你的福气，是一生的好运。
无论你有多么聪明，多么富有，多有权势，人愤怒的那一个瞬间，智商是零，过一分钟后恢复正常。
记住：千万不要愤怒的时候，做任何决策!
人的优雅关键在于控制自己情绪，用嘴伤害人，是最愚蠢的一种行为。我们的不自由，通常是因为来自内心的不良情绪左右了我们。
记住：一个能控制住不良情绪的人，比一个能拿下一座城的人更强大。
N*D
7 楼
link:http://aws.amazon.com/ec2/
http://aws.amazon.com/ec2/pricing/
我打算把我的一个能利用多cpu的系统移植到云上面，先看了下价格，上面是按
instance来算，我的系统一次计算要用8个cpu，最多可以有2个用户登录使用。这种情
况该怎么计算价格？是上面的价格乘以2，乘以8，还是乘以16。问题有些菜鸟，希望得
到指点。谢谢。
http://aws.amazon.com/ec2/pricing/
我打算把我的一个能利用多cpu的系统移植到云上面，先看了下价格，上面是按
instance来算，我的系统一次计算要用8个cpu，最多可以有2个用户登录使用。这种情
况该怎么计算价格？是上面的价格乘以2，乘以8，还是乘以16。问题有些菜鸟，希望得
到指点。谢谢。
a*j
8 楼
打算搬去TX 敢问各位同志 谁知道考完四门以后 在TX 成绩多久会过期
抱拳感谢
抱拳感谢
D*d
9 楼
TaxAct
z*h
10 楼
You have to file Form 5239 and Form 8606 to prove it is tax exemptable
Roth IRA is a joke
1099R
【在 l*********g 的大作中提到】
: 因为要用cash,去年从Roth IRA上取出$4000，这个钱要当作收入保税吗？
: 这个钱是税后存到Roth IRA上的，不应该再上税了。可是收到了Fedelity 寄来的1099R
: 。困惑中。。
Roth IRA is a joke
1099R
【在 l*********g 的大作中提到】
: 因为要用cash,去年从Roth IRA上取出$4000，这个钱要当作收入保税吗？
: 这个钱是税后存到Roth IRA上的，不应该再上税了。可是收到了Fedelity 寄来的1099R
: 。困惑中。。
h*n
11 楼
和好多吉他牛人合奏过了
好多是他的偶像
Tommy Emmanuel, Martin Taylor, Thomas Leeb, Ulli Bögershausen, Alex Kabasser, Trace Bundy, Tom Paldanius, Glen Hansard, Kotaro Oshio
Canon - Trace Bundy & Sungha Jung
Fight - Kotaro Oshio & Sungha Jung
好多是他的偶像
Tommy Emmanuel, Martin Taylor, Thomas Leeb, Ulli Bögershausen, Alex Kabasser, Trace Bundy, Tom Paldanius, Glen Hansard, Kotaro Oshio
Canon - Trace Bundy & Sungha Jung
Fight - Kotaro Oshio & Sungha Jung
A*u
12 楼
缺什么，就觉得啥重要
a9
13 楼
你得选哪个instance类型，按那个instance类型付钱就是了。
【在 N**D 的大作中提到】
: link:http://aws.amazon.com/ec2/
: http://aws.amazon.com/ec2/pricing/
: 我打算把我的一个能利用多cpu的系统移植到云上面，先看了下价格，上面是按
: instance来算，我的系统一次计算要用8个cpu，最多可以有2个用户登录使用。这种情
: 况该怎么计算价格？是上面的价格乘以2，乘以8，还是乘以16。问题有些菜鸟，希望得
: 到指点。谢谢。
【在 N**D 的大作中提到】
: link:http://aws.amazon.com/ec2/
: http://aws.amazon.com/ec2/pricing/
: 我打算把我的一个能利用多cpu的系统移植到云上面，先看了下价格，上面是按
: instance来算，我的系统一次计算要用8个cpu，最多可以有2个用户登录使用。这种情
: 况该怎么计算价格？是上面的价格乘以2，乘以8，还是乘以16。问题有些菜鸟，希望得
: 到指点。谢谢。
h*e
14 楼
doesn't expire.
a*o
15 楼
H&R block
s*y
16 楼
先看一下i1040的page 24。如果不符合execption，就要提交form 8606。
如果你取的钱(distribution)小于你投的钱(contribution)，那么f8606的第23行应该
是0。根据form 5329的说明i5329，当你f8606的第23行为0时，就不需要填f5329了。
然后在你1040的15a填4000，15b填0。
这是我研究的理解，请大家指正。
8606的worksheet挺清楚的。p590第67页上的worksheet让我很迷惑。
如果你取的钱(distribution)小于你投的钱(contribution)，那么f8606的第23行应该
是0。根据form 5329的说明i5329，当你f8606的第23行为0时，就不需要填f5329了。
然后在你1040的15a填4000，15b填0。
这是我研究的理解，请大家指正。
8606的worksheet挺清楚的。p590第67页上的worksheet让我很迷惑。
l*g
17 楼
这是天才
【在 h****n 的大作中提到】
: 韩国小朋友
: Fingerstyle Guitarist
: 9岁开始弹吉他，应该是06年
: 现在12岁
: 06年就能弹得不错了
: 最早的视频之一，当时才学琴几个月？人还没有吉他大。。。
【在 h****n 的大作中提到】
: 韩国小朋友
: Fingerstyle Guitarist
: 9岁开始弹吉他，应该是06年
: 现在12岁
: 06年就能弹得不错了
: 最早的视频之一，当时才学琴几个月？人还没有吉他大。。。
d*0
18 楼
我也想确定一下
是不是永远不过期阿？无论哪个州？
是不是永远不过期阿？无论哪个州？
y*e
19 楼
TaxCut
l*g
20 楼
Thanks a lot! I will check it.
【在 s******y 的大作中提到】
: 先看一下i1040的page 24。如果不符合execption，就要提交form 8606。
: 如果你取的钱(distribution)小于你投的钱(contribution)，那么f8606的第23行应该
: 是0。根据form 5329的说明i5329，当你f8606的第23行为0时，就不需要填f5329了。
: 然后在你1040的15a填4000，15b填0。
: 这是我研究的理解，请大家指正。
: 8606的worksheet挺清楚的。p590第67页上的worksheet让我很迷惑。
【在 s******y 的大作中提到】
: 先看一下i1040的page 24。如果不符合execption，就要提交form 8606。
: 如果你取的钱(distribution)小于你投的钱(contribution)，那么f8606的第23行应该
: 是0。根据form 5329的说明i5329，当你f8606的第23行为0时，就不需要填f5329了。
: 然后在你1040的15a填4000，15b填0。
: 这是我研究的理解，请大家指正。
: 8606的worksheet挺清楚的。p590第67页上的worksheet让我很迷惑。
c*n
21 楼
It doesn't expire so far now. But who knows the future.
a*j
22 楼
感谢
【在 h*********e 的大作中提到】
: doesn't expire.
【在 h*********e 的大作中提到】
: doesn't expire.
a*j
23 楼
多谢
【在 c********n 的大作中提到】
: It doesn't expire so far now. But who knows the future.
【在 c********n 的大作中提到】
: It doesn't expire so far now. But who knows the future.
a*j
24 楼
每个州不同 有的会过期
【在 d*********0 的大作中提到】
: 我也想确定一下
: 是不是永远不过期阿？无论哪个州？
【在 d*********0 的大作中提到】
: 我也想确定一下
: 是不是永远不过期阿？无论哪个州？
j*5
25 楼
应该说不会过期，但在CA，如果超过5年才申请license,需要同时提交48个（？）CPE。
其实他们只是怕你跟不上经常改革的会计制度方法，基础概念都是一样的，随时update
就行了。没必要难为大家再考一次吧。个人浅见。
其实他们只是怕你跟不上经常改革的会计制度方法，基础概念都是一样的，随时update
就行了。没必要难为大家再考一次吧。个人浅见。
c*6
26 楼
Thanks～
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