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Re: [转载] 求教:表兄妹结婚,后果真的很严重吗?
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Re: [转载] 求教:表兄妹结婚,后果真的很严重吗?# Biology - 生物学
y*e
1
几率大了很多。
因为每个人都携带几十个隐性致病基因,正常情况,父母携带相同的
隐性致病基因的概率很小。
但是,表兄妹这种情况严重的多。
假设每人携带20个隐性致病基因,兄妹之间将共享(Share)大约10
个,
表兄妹,是1/2*1/2*10=2.5个。每一个隐性共享致病基因,后代患

的概率是1/4。2.5个,将是大约1-(3/4)^2.5=51%。比较一般的遗传

的发病几率,大了1000倍左右。
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y*e
2
To make this more clear, I think my caculation won't differ
a lot
from the real world. Although, if we are talking a
perticular
disease, the danger is indeed not very high. Considering
there are
hundreds of locus for deadly genetic defect, another maybe
hundreds of
locus can increase your danger for cancer, heart attack, or
other
common diseases (which is not 100% controlled genetically).
It is
safe to say, first degree cousin marriage will sure give you
at
least one of the defect within those
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m*c
3
ask jews
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