MCBJC paper for discussion-042803 - 未名空间MITBBS历史存档

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MCBJC paper for discussion-042803

MCBJC paper for discussion-042803# Biology - 生物学

r*r2003-04-28 07:04

1 楼

A Role for Ran-GTP and Crm1 in Blocking Re-Replication.
Yamaguchi R, Newport J.
Department of Biology, University of California, San Diego, 9500 Gilman Drive,
92093, La Jolla, CA, USA
All eukaryotic cells have regulatory mechanisms that limit genomic replication
to a single round each cell cycle. These systems function by blocking
formation of prereplication complexes. The regulatory mechanisms in the yeast
S. cerevisiae have been identified, but these do not appear to be conserved in
metazoan

M*e2003-04-28 07:04

2 楼

this is a good paper that tries to dissect the regulatory
mechanism of strict control on DNA replication during cell
cycle. to ensure only one round of DNA replication at each
S phase, yeast S. cerevisiae exploits cdk2 kinase to regulate
functionally reduntant pathways: degradation of Cdc6, export
of MCM from the nucleus, and phosphorylation of ORC. however,
the mechanism in metazoan is unclear while the cellular
targets of cdk2 have not been completely understood yet.
the author (only one besid