Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy - 未名空间MITBBS历史存档

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Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy# Biology - 生物学

h*a2011-11-11 08:11

1 楼

旧的Citi Dividend Platinum Select Mastercard for College Students有效期要到
了，然后给我送了张新卡过来，想都没想就激活了，然后才注意到现在是Dividend
mastercard了... matercard标志上面还有WORLD的字样...
俩卡有啥区别么？似乎cashback program没什么区别.
这个是world mastercard么？有啥好benefit么？像 visa preferred可以买半价票那种？
至少看了下租车还是secondary coverage的样子~

s*82011-11-11 08:11

2 楼

当然，我从1月中旬到4月上旬申请了高级会员，可以看别人联系方式和发送站内信件。
以下几封信均为我在高级会员时期发的：
1：以下是发给一个比本人小一岁，在北京工作，大学文化，身高1.64m的女孩发的：
亲爱的******，你好！
直觉让我相信你非常有内涵，本人最喜欢像你这样的芳草型女孩。同时，由于咱们年龄
差不
多，而且看你在网上的自我介绍，我敢断定你和我一样，也是孤身在外面闯荡多年，远
离父
母。其实两个人都处在这种情况下，才能彼此迸发出真正的爱情。有了你对我坚强依靠
的需
要，我也会更加有事业心和前进的动力。
本人****大学本科，现在某全美排名100左右学校读**工程硕士，马上毕业
，最近在忙硕士论文，和申请在美国继续读博士。由于美国经济依然恶劣，就业形势严
峻，
博士很多学校也没有奖学金，本人也很可能马上回国工作。
本人热爱游泳、篮球和长跑、骑车、爬山等户外活动，曾两次用4小时1刻钟跑完**马拉松
全程。同时本人喜欢素描、书法和演奏萨克斯风，一定程度懂得艺术的真正内涵:使充
满矛
盾的事物之间达成和谐。这些充满矛盾的事物，比如照顾家庭和专心事业，追求物质丰
富和
懂得关爱这个世界，等等。毕竟真正的爱情，是建立在男女之间的真感情的基础上。那
些一
心想依靠成功男人来过一辈子的女孩，我真为她们失去的做人应有的尊严感到惋惜！
都说我们**大是“爱情之花盛开的地方”，但是由于之前一直忙碌于学业和前途，没有
任何
精力考虑恋爱的问题。况且恋爱绝对不是花前月下的享受，爱情的浪漫，也是建立在彼
此的
关爱和责任感之上的，是一种超然的心态。****“自强不息******”的校训，一直激励
着我的留学生活。更重要的是其的文化积淀和自然环境，让我明白了怎样的女生才是真正
的美女，并懂得了如何正确的欣赏女生。
顺便，我是在我们这里一比较出名的华人社区--未名空间每个页面左下方的侧链中看见
的这
个国际性华人交友网站。还有，本人在**省长大，4年前由于父母调动工作，我家现在
广州
。虽然父母声称可以帮我在北京或广州找到我所向往的****设计方面的工作，当然要是
你觉
得我可靠的话，他们今后也可能同时帮你在这两个地方找到相对稳定的工作，以解除咱
们的
后顾之忧。但是，他们所能帮咱们找到的表面看似稳定的工作，同样需要咱们不断学习
，不
断充实自己，才能实现真正的稳定。希望今后咱们能共同监督和激励，不希望晚上和周
末尽
量把时间浪费在上网娱乐以及那些娱乐场所，多静下心来读好书，和多自学些对职业发
展有
用的技能。毕竟一个美好的家庭是靠两个人来共同支撑的，要是男人成天在外不顾家且
女人
成了帮男人照看孩子和处理家务的工具，这样对一个家庭的和谐和发展其实是致命的伤
害。
好的，我要睡了，先写到这里吧，不管你是否回复，都非常感谢你能抽出宝贵时间读完
我的
来信。
清明节快乐！
2：以下是发给另外一个在俄亥俄读Master的女生：
Merry Christmas and Happy New Year!
I saw you in my “速配推荐” in my homepage when I landed on this site
occasionally during my relaxation peroid from my work for Master thesis.
After browsing
you carefully,I found we should be agreeable to each other.As a student
majored
in engineer,I am busy all the time and seldom have any chance to get in
touch with
any Chinese girl around.This is why I use this website.And I knew about
this website
from the links on MITBBS.
Also I was born and grew up in ****** province,though my home is currently
located
in Guangzhou as my parents changed their work about four years ago.Now I am
currently
a graduate student in a satellite city of New York City.
At first I have to aware you be careful when making friends online,as many
people
may use falsified photos,or just take other one's photo as his own photo.
Then,as
we are still students,we should not be so worried about our marriage,though
our
parents may have started to urge us in our phone calls with them.We should
first
make good use of the time at school to learn skills helpful in standing
competitive
in the future,and try to make as many friends as possible with people from
all over
the world,with diverse cultures and languages
.
At last,as all of us are far away from our parents and relatives,what we
should do
is just to help each other when needed,and share ideas and methods to face
our study
and daily life.When you come to NYC,you can ask me for help if possible.
Also when
you are in China,you can also contact me when you go to Guangzhou.
Thanks very much for your patience,and best wishes to you!

d*p2011-11-11 08:11

3 楼

http://www.nejm.org/doi/full/10.1056/NEJMoa1106152
这几天太忙，没来得及转，在DC immunotherapy 会议上他们就报告了，非常的
exciting.

z*e2011-11-11 08:11

4 楼

基本没好处.
我的也被换了.

v*s2011-11-11 08:11

5 楼

哈哈哈，很欢乐
能转joke不？谢谢分享！

n*k2011-11-11 08:11

6 楼

not in the field...a bit surprised how far people have gone into the
clinical testing but this is a perfect example how a routine tech in a basic
research area could turn into something exciting/useful in a clinical
setting...if my memory is right, this iCap strategy has been around at least
a decade and is widely used in animal study for various purpose...

【在 d*p 的大作中提到】

: http://www.nejm.org/doi/full/10.1056/NEJMoa1106152
: 这几天太忙，没来得及转，在DC immunotherapy 会议上他们就报告了，非常的
: exciting.

z*i2011-11-11 08:11

7 楼

CO的world 卡是primary coverage 看来两种卡还是有区别的啊

f*i2011-11-11 08:11

8 楼

你是真心求分析啊还是来搞笑的？越看越像冷笑话啊。。不是坑吧？
这要真是你写的，只能说，你太不了解女孩子心理啦。

d*p2011-11-11 08:11

9 楼

Idea is not new, but make it happen in human is very exciting. Clean 90%
cells in 4 hours. 24 hours, all active cells will be cleaned. The safety of
cell therapy will no longer be a big issue now.

z*e2011-11-11 08:11

10 楼

co的primary coverage是chase银行给的福利,不是world master给的.

s*82011-11-11 08:11

11 楼

是啊，这就是我写的啊
我还是学生，没有那么多时间浪费！

【在 f*****i 的大作中提到】

: 你是真心求分析啊还是来搞笑的？越看越像冷笑话啊。。不是坑吧？
: 这要真是你写的，只能说，你太不了解女孩子心理啦。

n*k2011-11-11 08:11

12 楼

The safety of cell therapy will no longer be a big issue now.
Maybe true for certain treatments but generally speaking, I bet this is by
far a too bold statement and is bound to be wrong...for those issues of
tumorigenic nature, it would still stand. Otherwise we would have cured
cancers, right? capases related pathways have proven to have somewhat
limited usages in cancer treatments and tumor cells have evolved ways to
escape from it...and some of the early ones functioned in a way other than
as expected...I would be cautiously excited...

of

【在 d*p 的大作中提到】

: Idea is not new, but make it happen in human is very exciting. Clean 90%
: cells in 4 hours. 24 hours, all active cells will be cleaned. The safety of
: cell therapy will no longer be a big issue now.

m*22011-11-11 08:11

13 楼

借宝地问一下目前哪些卡的租车是PRIMARY COVERAGE.
看了一下我手头上的几张,全是SECONDARY.

【在 z****e 的大作中提到】

: co的primary coverage是chase银行给的福利,不是world master给的.

s*s2011-11-11 08:11

14 楼

如果不是JOKE，本人意见
对陌生人都这么多话。。。让人觉的不放心
而且会觉的这是模版
再来会让人觉的你DESPERATE。。。是没人要的主，干嘛我接盘
对什么人说什么话，先从最简单的打招呼开始

d*p2011-11-11 08:11

15 楼

I guess you don't have much background of cell therapy. So far, only the
therapy with the Y-chain recovery in stem cell is oncogenic, and the main
reason is because strong signal of Y chain itself induces lymphoma instead
of the viral integration. For all the T cell or DC therapies which have been
in clinical for a long time, 0 case with lymphoma.
Well, I still agree with you on the concerns of using in stem cell
therapy. For my understanding, once the stem cell in the therapy will not
produce T/B cell, which usually go through somatic recombination due to TCR,
BCR rearrange, with a lot of DNA broken, the major oncogenic reason, I won'
t worry too much about the safety now.

h*a2011-11-11 08:11

16 楼

CO那张居然也是world啊。。。没注意~
还是visa preferred实惠点，每周五半价电影...

【在 z*******i 的大作中提到】

: CO的world 卡是primary coverage 看来两种卡还是有区别的啊

S*f2011-11-11 08:11

17 楼

同意楼上的
另外，你虽然写了很多
但是没有那句话能让人女孩知道你有心了解她
说不定这同样的话已经被你copy/paste发送过很多女生了

n*k2011-11-11 08:11

18 楼

Are u talking about stem cell therapy in general or more about in immuno-
lineage? Seems to me, you are referring to the T cell or DC therapies etc..
.BTW, I have no experiences with cell therapy except from research point of
view...and I am not working in blood-related lineages either...

the
been
TCR,
won'

【在 d*p 的大作中提到】

: I guess you don't have much background of cell therapy. So far, only the
: therapy with the Y-chain recovery in stem cell is oncogenic, and the main
: reason is because strong signal of Y chain itself induces lymphoma instead
: of the viral integration. For all the T cell or DC therapies which have been
: in clinical for a long time, 0 case with lymphoma.
: Well, I still agree with you on the concerns of using in stem cell
: therapy. For my understanding, once the stem cell in the therapy will not
: produce T/B cell, which usually go through somatic recombination due to TCR,
: BCR rearrange, with a lot of DNA broken, the major oncogenic reason, I won'
: t worry too much about the safety now.

h*a2011-11-11 08:11

19 楼

primary coverage似乎AMEX某张卡有？哪位大牛来科普下哈~
不然我知道的就只有CO和UA的那张CHASE了~

【在 m****2 的大作中提到】

:
: 借宝地问一下目前哪些卡的租车是PRIMARY COVERAGE.
: 看了一下我手头上的几张,全是SECONDARY.

d*p2011-11-11 08:11

20 楼

I am talking about general cell therapy. Oncogenic is only one part of the
safety issue. For example, one major concern of T cell therapy is over-
activated T cell might cause autoimmune disease, which is a very common
problem in stem cell and organ transplant, including cancer immunotherapy.
Rosenberg, a big name in cancer immune therapy, killed one patient due to
the infused Her2/neu targeting T cell were activated in lung.
Stem cell therapy actually only account for a small part of cell therapy.
Again, as I said, once the stem cell is not for T/B cell reconstitution, the
oncogenic possibility is very very low. 0 report from clinical so far. Even
the purpose of stem cell therapy is to reconstitute the hematological
system, it will have better security with this technology, given cas9 is
quite downstream of the apoptotic signal pathway.
Whatever, we would not expect this technology will figure out everything

b*i2011-11-11 08:11

21 楼

Amex 似乎都是...

n*b2011-11-11 08:11

22 楼

This seems to be a solid clinical trial for an old concept.
But the scope of the problem seems to be limited. It begins with some
negative effects of donor T cells during HSCT, which seems to be manageable
through many other means. Specifically, if one can produce a cocktail of
cytokines there will be no such a problem to begin with.
Having said that, the real application of this technique may be at the
controlled differentiation after stem cell transplantation.

z*e2011-11-11 08:11

23 楼

租车primary coverage目前大家用得比较多的是AMEX Premium Car Rental Protection
,需要enroll,每次租车用AMEX的卡付钱，自动一次性扣$19.95.保damage, theft,
personal property以及accidental Injury.
还是就是chase的onepass plus卡，免费，但是只保collision damage.

【在 m****2 的大作中提到】

:
: 借宝地问一下目前哪些卡的租车是PRIMARY COVERAGE.
: 看了一下我手头上的几张,全是SECONDARY.

n*k2011-11-11 08:11

24 楼

Maybe I am just not well informed: has anyone clarified on the neural stem
transplantation case last year....I thought there was tumor formation four
ys after the neural stem cell transplanation for the kid, and some of
experts' argument against were pretty lame I would say...I don't know how
much experience we have so far over stem cell therapy and do we really have
a decent handle of the potential for tumors, beyond some other problems you
have listed?

the
Even

【在 d*p 的大作中提到】

: I am talking about general cell therapy. Oncogenic is only one part of the
: safety issue. For example, one major concern of T cell therapy is over-
: activated T cell might cause autoimmune disease, which is a very common
: problem in stem cell and organ transplant, including cancer immunotherapy.
: Rosenberg, a big name in cancer immune therapy, killed one patient due to
: the infused Her2/neu targeting T cell were activated in lung.
: Stem cell therapy actually only account for a small part of cell therapy.
: Again, as I said, once the stem cell is not for T/B cell reconstitution, the
: oncogenic possibility is very very low. 0 report from clinical so far. Even
: the purpose of stem cell therapy is to reconstitute the hematological

h*a2011-11-11 08:11

25 楼

赞ls

m*22011-11-11 08:11

26 楼

Protection
多谢羊羊的信息.
刚看了一下AMEX的AMEX Premium Car Rental Protection,条款相当不错,还没
DEDUCTIBLE.
不过目前我只有一张FIA的AMEX.这个PROGRAM需要AMEX自家的卡才行...
看明年吧,冲一下SPG.今年不行了.

【在 z****e 的大作中提到】

: 租车primary coverage目前大家用得比较多的是AMEX Premium Car Rental Protection
: ,需要enroll,每次租车用AMEX的卡付钱，自动一次性扣$19.95.保damage, theft,
: personal property以及accidental Injury.
: 还是就是chase的onepass plus卡，免费，但是只保collision damage.

z*i2011-11-11 08:11

27 楼

原来这样啊明白了

【在 z****e 的大作中提到】

: co的primary coverage是chase银行给的福利,不是world master给的.

z*i2011-11-11 08:11

28 楼

complete savings有五块钱的电影票fandango 可以看imax 3d的 visa signature还有
时间跟数目的限制

【在 h*****a 的大作中提到】

: 赞ls

m*72011-11-11 08:11

29 楼

mark

Protection

【在 z****e 的大作中提到】

m*22011-11-11 08:11

30 楼

嗯.CS买的$5电影票确实爽.我昨晚才去看了FF5.
不过CS之前的PAPER TICKET限制是每月6张,ONLINE TICKET不知道有没有限制.
不过我估计自己一个月也不会买6张.

【在 z*******i 的大作中提到】

:
: complete savings有五块钱的电影票fandango 可以看imax 3d的 visa signature还有
: 时间跟数目的限制

p*i2011-11-11 08:11

31 楼

amex要花钱买的

Amex 似乎都是...

【在 b******i 的大作中提到】

: Amex 似乎都是...