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Re: 麻省科学家发现病毒克星“天龙” (转载)
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Re: 麻省科学家发现病毒克星“天龙” (转载)# Biology - 生物学
t*e
1
咨询一下,谢谢
avatar
d*o
2
天象已动,气温反复无常,是生物的催命符,因为影响一切生物最重要的因子就是温度
,这就是恒温动物为什么有优势的原因。尔后地象随之,火山爆发,10级大地震将在人
口稠密处发生。地震不仅带来海啸,而且改变地势,原先的陆地将被水淹。我与道同在
,早已视死如归,但道不会轻易让我死,因为我在人间的使命还没有完成。我所住之地
都是福地,我从小到大从未遭受自然灾害。你如果也诚信道,你所住之地也将是福地,
哪怕你周围全被淹。要想诚信道,首先要做一个诚信之人,你骗得了人,却骗不了道。
大审判即将到来,各安天命吧。
附注:地震专家:地球可能发生10级大地震 应进行防范
中新网11月22日电 据日本新闻网报道,日本东北大学地震专家松泽畅教授21日在
东京举行的地震专家会议上发表了一份研究报告,报告指出,根据地球板块长度判断,
地球上有可能发生里氏10级的超大型地震。里氏10级的地震所发出的能量为去年日本“
3・11大地震”的30倍左右。、
松泽教授在会议上表示,在“3・11大地震”发生之前,谁都没有预想会发
生里氏9级地震。但是在没有任何预测和防御的情况下,大地震还是发生了。目前虽然
无法确定一定会发生里氏10级超大型地震,但是就算发生的可能性很低,还是有必要对
里氏10级超大型地震进行研究和防范。
至今为止,全球上有记录的最大地震是1960年发生在南美智利的里氏9.5级大地震
。在那一次大地震中,长达1千公里的断层发生移动。松泽教授表示,如果设想更大的
断层移动的话,将会引发更大规模的地震。例如,从北美到勘察加半岛,然后沿着日本
南部海沟的断层为8800公里。如果这个断层移动20米的话,有可能发生里氏10级的超大
型地震。10级地震发生的话,地震可能会持续20分钟到1个小时。而海啸将在地震结束
之前到达,同时可能会持续数日。
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i*h
3
是政治,不是技术
眼下看两败,长远看对苹果是利好
大把现金砸下去,总能把地图做好的,在用户的脖子上又勒了一圈
狗狗却只能看着失去大批用户和数据源
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s*e
4
感觉挺不错,做工也很好,可惜就是面板边框有几个地方有点松,手压下去感觉有活动
,网上搜了一下,很多都这样,不知道大家的有没有注意到。
用自带的browser上了会儿网,速度很快,可惜没有adblock,很多网站被pop up搞的乱
七八糟的。copy了几本书看了看,也很不错,屏幕很亮很细腻,比kindle那灰不溜秋的
界面强太多了。我的手比较大,用一只手抓着正合适。
感觉功能挺不错的,都懒得root了,我也就是看看书上上网,如果有个带adblock的
browser就更好了。
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v*s
5
【 以下文字转载自 Joke 讨论区 】
发信人: mutouhui (mutouhui), 信区: Joke
标 题: Re: 麻省科学家发现病毒克星“天龙”
发信站: BBS 未名空间站 (Sun Nov 13 19:08:54 2011, 美东)
http://web.mit.edu/press/2011/antiviral.html
New drug could cure nearly any viral infection
Researchers at MIT’s Lincoln Lab have developed technology that may someday
cure the common cold, influenza and other ailments.
CAMBRIDGE, Mass. — Most bacterial infections can be treated with
antibiotics such as penicillin, discovered decades ago. However, such drugs
are useless against viral infections, including influenza, the common cold,
and deadly hemorrhagic fevers such as Ebola.
Now, in a development that could transform how viral infections are treated,
a team of researchers at MIT’s Lincoln Laboratory has designed a drug that
can identify cells that have been infected by any type of virus, then kill
those cells to terminate the infection.
In a paper published July 27 in the journal PLoS One, the researchers tested
their drug against 15 viruses, and found it was effective against all of
them — including rhinoviruses that cause the common cold, H1N1 influenza, a
stomach virus, a polio virus, dengue fever and several other types of
hemorrhagic fever.
The drug works by targeting a type of RNA produced only in cells that have
been infected by viruses. “In theory, it should work against all viruses,”
says Todd Rider, a senior staff scientist in Lincoln Laboratory’s Chemical
, Biological, and Nanoscale Technologies Group who invented the new
technology.
Because the technology is so broad-spectrum, it could potentially also be
used to combat outbreaks of new viruses, such as the 2003 SARS (severe acute
respiratory syndrome) outbreak, Rider says.
Other members of the research team are Lincoln Lab staff members Scott Wick,
Christina Zook, Tara Boettcher, Jennifer Pancoast and Benjamin Zusman.
Few antivirals available
Rider had the idea to try developing a broad-spectrum antiviral therapy
about 11 years ago, after inventing CANARY (Cellular Analysis and
Notification of Antigen Risks and Yields), a biosensor that can rapidly
identify pathogens. “If you detect a pathogenic bacterium in the
environment, there is probably an antibiotic that could be used to treat
someone exposed to that, but I realized there are very few treatments out
there for viruses,” he says.
There are a handful of drugs that combat specific viruses, such as the
protease inhibitors used to control HIV infection, but these are relatively
few in number and susceptible to viral resistance.
Rider drew inspiration for his therapeutic agents, dubbed DRACOs (Double-
stranded RNA Activated Caspase Oligomerizers), from living cells’ own
defense systems.
When viruses infect a cell, they take over its cellular machinery for their
own purpose — that is, creating more copies of the virus. During this
process, the viruses create long strings of double-stranded RNA (dsRNA),
which is not found in human or other animal cells.
As part of their natural defenses against viral infection, human cells have
proteins that latch onto dsRNA, setting off a cascade of reactions that
prevents the virus from replicating itself. However, many viruses can
outsmart that system by blocking one of the steps further down the cascade.
Rider had the idea to combine a dsRNA-binding protein with another protein
that induces cells to undergo apoptosis (programmed cell suicide) —
launched, for example, when a cell determines it is en route to becoming
cancerous. Therefore, when one end of the DRACO binds to dsRNA, it signals
the other end of the DRACO to initiate cell suicide.
Combining those two elements is a “great idea” and a very novel approach,
says Karla Kirkegaard, professor of microbiology and immunology at Stanford
University. “Viruses are pretty good at developing resistance to things we
try against them, but in this case, it’s hard to think of a simple pathway
to drug resistance,” she says.
Each DRACO also includes a “delivery tag,” taken from naturally occurring
proteins, that allows it to cross cell membranes and enter any human or
animal cell. However, if no dsRNA is present, DRACO leaves the cell unharmed.
Most of the tests reported in this study were done in human and animal cells
cultured in the lab, but the researchers also tested DRACO in mice infected
with the H1N1 influenza virus. When mice were treated with DRACO, they were
completely cured of the infection. The tests also showed that DRACO itself
is not toxic to mice.
The researchers are now testing DRACO against more viruses in mice and
beginning to get promising results. Rider says he hopes to license the
technology for trials in larger animals and for eventual human clinical
trials.
This work is funded by a grant from the National Institute of Allergy and
Infectious Diseases and the New England Regional Center of Excellence for
Biodefense and Emerging Infectious Diseases, with previous funding from the
Defense Advanced Research Projects Agency, Defense Threat Reduction Agency,
and Director of Defense Research & Engineering (now the Assistant Secretary
of Defense for Research and Engineering).
avatar
P*0
6
什么身份回来?

【在 t******e 的大作中提到】
: 咨询一下,谢谢
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d*r
7
啥时候结束?

在人
同在
之地
地,
道。
断,

【在 d***o 的大作中提到】
: 天象已动,气温反复无常,是生物的催命符,因为影响一切生物最重要的因子就是温度
: ,这就是恒温动物为什么有优势的原因。尔后地象随之,火山爆发,10级大地震将在人
: 口稠密处发生。地震不仅带来海啸,而且改变地势,原先的陆地将被水淹。我与道同在
: ,早已视死如归,但道不会轻易让我死,因为我在人间的使命还没有完成。我所住之地
: 都是福地,我从小到大从未遭受自然灾害。你如果也诚信道,你所住之地也将是福地,
: 哪怕你周围全被淹。要想诚信道,首先要做一个诚信之人,你骗得了人,却骗不了道。
: 大审判即将到来,各安天命吧。
: 附注:地震专家:地球可能发生10级大地震 应进行防范
: 中新网11月22日电 据日本新闻网报道,日本东北大学地震专家松泽畅教授21日在
: 东京举行的地震专家会议上发表了一份研究报告,报告指出,根据地球板块长度判断,

avatar
M*n
8
谁地图做得好用谁的呗,这又不是垄断行业,还有那么多家做导航的呢
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s*l
9
“屏幕很亮很细腻,比kindle那灰不溜秋的界面强太多了”
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m*i
10
joke版转回来的, 呵呵
大伙儿议议.

someday
drugs
,

【在 v*****s 的大作中提到】
: 【 以下文字转载自 Joke 讨论区 】
: 发信人: mutouhui (mutouhui), 信区: Joke
: 标 题: Re: 麻省科学家发现病毒克星“天龙”
: 发信站: BBS 未名空间站 (Sun Nov 13 19:08:54 2011, 美东)
: http://web.mit.edu/press/2011/antiviral.html
: New drug could cure nearly any viral infection
: Researchers at MIT’s Lincoln Lab have developed technology that may someday
: cure the common cold, influenza and other ailments.
: CAMBRIDGE, Mass. — Most bacterial infections can be treated with
: antibiotics such as penicillin, discovered decades ago. However, such drugs

avatar
t*e
11
还是F1,签证还是有效的

【在 P******0 的大作中提到】
: 什么身份回来?
avatar
d*o
12
粗略估计14年

【在 d******r 的大作中提到】
: 啥时候结束?
:
: 在人
: 同在
: 之地
: 地,
: 道。
: 断,

avatar
g*g
13
Dolphin has adblock plugin but it's not very stable.

【在 s*******e 的大作中提到】
: 感觉挺不错,做工也很好,可惜就是面板边框有几个地方有点松,手压下去感觉有活动
: ,网上搜了一下,很多都这样,不知道大家的有没有注意到。
: 用自带的browser上了会儿网,速度很快,可惜没有adblock,很多网站被pop up搞的乱
: 七八糟的。copy了几本书看了看,也很不错,屏幕很亮很细腻,比kindle那灰不溜秋的
: 界面强太多了。我的手比较大,用一只手抓着正合适。
: 感觉功能挺不错的,都懒得root了,我也就是看看书上上网,如果有个带adblock的
: browser就更好了。

avatar
w*a
14
看见plos one就没往下看了。。。

【在 m******i 的大作中提到】
: joke版转回来的, 呵呵
: 大伙儿议议.
:
: someday
: drugs
: ,

avatar
t*t
15
毕业日之前回来没问题,毕业后不知道...
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s*e
16

这个需要root吧,其实都把root的SD做好了,结果来了之后发现借口是microSD,就凑
活着用了一下,结果发现不root也够用了好像

【在 g*****g 的大作中提到】
: Dolphin has adblock plugin but it's not very stable.
avatar
x*y
17
很有创意,只是还不够完善。看看其他的评论:
Broad-spectrum antiviral strategy
Peter Hare
Journal name:
Nature Biotechnology
Volume:
29,
Page:
885
Year published:
(2011)
DOI:
doi:10.1038/nbt.2014
Published online13 October 2011Most antiviral therapies are pathogen-
specific and likely to select for resistance if the virus can mutate the
drug target. Rider et al. couple the ability to detect long double-stranded
RNA (dsRNA)—a telltale indicator of viral infection in mammalian cells—
with procaspase-activated apoptosis for broad-spectrum antiviral activity.
Dubbed DRACOs (double-stranded RNA–activated caspase oligomerizers), these
chimeric constructs each comprise (i) a terminal transduction domain for
cell penetration, (ii) a dsRNA-binding domain to detect viral infection and
(iii) an apoptosis-promoting domain, such as a procaspase-binding domain or
a procaspase, which is activated by dsRNA-dependent oligomerization. When
tested in 11 mammalian cell types, DRACOs are effective against 15 different
viruses. Prophylactic intraperitoneal delivery of DRACOs also reduces the
morbidity of mice following subsequent intranasal challenge with H1N1
influenza virus. The strategy seems best suited to situations when exposure
to a dangerous virus is anticipated; in contrast, once an infection is
established, the treatment may result in potentially dangerous inflammation
and organ damage. Unfortunately, the earliest stages of viral infection are
usually the most difficult to diagnose. Systemic delivery of DRACOs might
also result in nondiscriminate killing of healthy cells infected with
nonpathogenic viruses. (PLoS One 6, e22572, 2011)
avatar
P*0
18
那应该没什么问题吧。

【在 t******e 的大作中提到】
: 还是F1,签证还是有效的
avatar
g*g
19
No, Dolphin is just a regular app.

【在 s*******e 的大作中提到】
:
: 这个需要root吧,其实都把root的SD做好了,结果来了之后发现借口是microSD,就凑
: 活着用了一下,结果发现不root也够用了好像

avatar
g*0
20
基于欲练神功,必先自宫的原理。
avatar
t*e
21
我是毕业之前回来
我申请的是post-opt也没有问题?

【在 t********t 的大作中提到】
: 毕业日之前回来没问题,毕业后不知道...
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s*e
22

Thanks will check it out.

【在 g*****g 的大作中提到】
: No, Dolphin is just a regular app.
avatar
t*e
23
不会说opt的申请自动失效吧,我记得h1b的申请一旦开始了,人如果离开美国,
就自动void h1b的申请

【在 P******0 的大作中提到】
: 那应该没什么问题吧。
avatar
c*y
24
it's so much with cm7, a lot faster.... only issue is g market often doesn't
allow you to download app
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r*t
25
我的拿到手很多 ghost click, 贴了魔都不管用,最后是 calibrate 了下触屏就好了。

【在 s*******e 的大作中提到】
: 感觉挺不错,做工也很好,可惜就是面板边框有几个地方有点松,手压下去感觉有活动
: ,网上搜了一下,很多都这样,不知道大家的有没有注意到。
: 用自带的browser上了会儿网,速度很快,可惜没有adblock,很多网站被pop up搞的乱
: 七八糟的。copy了几本书看了看,也很不错,屏幕很亮很细腻,比kindle那灰不溜秋的
: 界面强太多了。我的手比较大,用一只手抓着正合适。
: 感觉功能挺不错的,都懒得root了,我也就是看看书上上网,如果有个带adblock的
: browser就更好了。

avatar
c*o
26
这个好解决,只要把Market卸载一下就可以了,因为Market自动更新之后,好像不认NC
,卸载就是恢复到CM7适用的老版本。
话说NC支持blue tooth、microSD,usb host,又有成熟稳定的超频内核,还便宜,秒
杀kindle fire啊。

't

【在 c*y 的大作中提到】
: it's so much with cm7, a lot faster.... only issue is g market often doesn't
: allow you to download app

avatar
s*e
27
对了有没有人感觉那个充电的口特别紧啊?我第一次只插进去一半,后来用了很大的力
气才插到底,总怕把它弄坏了。
avatar
c*o
28
多抽查几次就松了。道理是一样的,哈哈。

【在 s*******e 的大作中提到】
: 对了有没有人感觉那个充电的口特别紧啊?我第一次只插进去一半,后来用了很大的力
: 气才插到底,总怕把它弄坏了。

avatar
s*e
29
对了,给个刷cm7的link吧?

NC

【在 c****o 的大作中提到】
: 这个好解决,只要把Market卸载一下就可以了,因为Market自动更新之后,好像不认NC
: ,卸载就是恢复到CM7适用的老版本。
: 话说NC支持blue tooth、microSD,usb host,又有成熟稳定的超频内核,还便宜,秒
: 杀kindle fire啊。
:
: 't

avatar
c*o
30
直接装sd上,用verygreen's installer,超简单:
http://forum.xda-developers.com/showthread.php?t=1000957
7.1RC1已经很稳定了:
http://download.cyanogenmod.com/?type=RC&device=encore
然后再装个dalingrin's oc kernel:
http://forum.xda-developers.com/showthread.php?t=925451
主意要用这个image:
http://coachz.inetpro.org/~dalingrin/nook/kernels/063011/update
然后用verygreen's installer装上。
全部时间10分钟。

【在 s*******e 的大作中提到】
: 对了,给个刷cm7的link吧?
:
: NC

avatar
s*e
31
多谢!

【在 c****o 的大作中提到】
: 直接装sd上,用verygreen's installer,超简单:
: http://forum.xda-developers.com/showthread.php?t=1000957
: 7.1RC1已经很稳定了:
: http://download.cyanogenmod.com/?type=RC&device=encore
: 然后再装个dalingrin's oc kernel:
: http://forum.xda-developers.com/showthread.php?t=925451
: 主意要用这个image:
: http://coachz.inetpro.org/~dalingrin/nook/kernels/063011/update
: 然后用verygreen's installer装上。
: 全部时间10分钟。

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