t*d
2 楼
真是有钱人会更有钱
Exercise benefits a variety of organ systems in mammals, and some of the
best-recognized effects of exercise on muscle are mediated by the
transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we
show in mouse that PGC1-α expression in muscle stimulates an increase in
expression of FNDC5, a membrane protein that is cleaved and secreted as a
newly identified hormone, irisin. Irisin acts on white adipose cells in
culture and in vivo to stimulate UCP1 expression and a broad program of
brown-fat-like development. Irisin is induced with exercise in mice and
humans, and mildly increased irisin levels in the blood cause an increase in
energy expenditure in mice with no changes in movement or food intake. This
results in improvements in obesity and glucose homeostasis. Irisin could be
therapeutic for human metabolic disease and other disorders that are
improved with exercise.
Nature 481, 463–468
Exercise benefits a variety of organ systems in mammals, and some of the
best-recognized effects of exercise on muscle are mediated by the
transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we
show in mouse that PGC1-α expression in muscle stimulates an increase in
expression of FNDC5, a membrane protein that is cleaved and secreted as a
newly identified hormone, irisin. Irisin acts on white adipose cells in
culture and in vivo to stimulate UCP1 expression and a broad program of
brown-fat-like development. Irisin is induced with exercise in mice and
humans, and mildly increased irisin levels in the blood cause an increase in
energy expenditure in mice with no changes in movement or food intake. This
results in improvements in obesity and glucose homeostasis. Irisin could be
therapeutic for human metabolic disease and other disorders that are
improved with exercise.
Nature 481, 463–468
s*y
3 楼
靠，一众药品公司的各位美女代表们现在肯定在疯狂的敲他办公室的们
in
【在 t*d 的大作中提到】
: 真是有钱人会更有钱
: Exercise benefits a variety of organ systems in mammals, and some of the
: best-recognized effects of exercise on muscle are mediated by the
: transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we
: show in mouse that PGC1-α expression in muscle stimulates an increase in
: expression of FNDC5, a membrane protein that is cleaved and secreted as a
: newly identified hormone, irisin. Irisin acts on white adipose cells in
: culture and in vivo to stimulate UCP1 expression and a broad program of
: brown-fat-like development. Irisin is induced with exercise in mice and
: humans, and mildly increased irisin levels in the blood cause an increase in
in
【在 t*d 的大作中提到】
: 真是有钱人会更有钱
: Exercise benefits a variety of organ systems in mammals, and some of the
: best-recognized effects of exercise on muscle are mediated by the
: transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we
: show in mouse that PGC1-α expression in muscle stimulates an increase in
: expression of FNDC5, a membrane protein that is cleaved and secreted as a
: newly identified hormone, irisin. Irisin acts on white adipose cells in
: culture and in vivo to stimulate UCP1 expression and a broad program of
: brown-fat-like development. Irisin is induced with exercise in mice and
: humans, and mildly increased irisin levels in the blood cause an increase in
d*3
4 楼
That's very good science but still far from a drug.
n*k
5 楼
was in his talk about a big half y ago, pretty impressive, sometimes one
could be wondering whether it is due to vision or serendipity, anyone could
possibly predict why evolution/God has chosen this design...it seems several
groups are working on this/or along the same line...
in
【在 t*d 的大作中提到】
: 真是有钱人会更有钱
: Exercise benefits a variety of organ systems in mammals, and some of the
: best-recognized effects of exercise on muscle are mediated by the
: transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we
: show in mouse that PGC1-α expression in muscle stimulates an increase in
: expression of FNDC5, a membrane protein that is cleaved and secreted as a
: newly identified hormone, irisin. Irisin acts on white adipose cells in
: culture and in vivo to stimulate UCP1 expression and a broad program of
: brown-fat-like development. Irisin is induced with exercise in mice and
: humans, and mildly increased irisin levels in the blood cause an increase in
could be wondering whether it is due to vision or serendipity, anyone could
possibly predict why evolution/God has chosen this design...it seems several
groups are working on this/or along the same line...
in
【在 t*d 的大作中提到】
: 真是有钱人会更有钱
: Exercise benefits a variety of organ systems in mammals, and some of the
: best-recognized effects of exercise on muscle are mediated by the
: transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we
: show in mouse that PGC1-α expression in muscle stimulates an increase in
: expression of FNDC5, a membrane protein that is cleaved and secreted as a
: newly identified hormone, irisin. Irisin acts on white adipose cells in
: culture and in vivo to stimulate UCP1 expression and a broad program of
: brown-fat-like development. Irisin is induced with exercise in mice and
: humans, and mildly increased irisin levels in the blood cause an increase in
y*i
6 楼
you will be surprised.
【在 d***3 的大作中提到】
: That's very good science but still far from a drug.
【在 d***3 的大作中提到】
: That's very good science but still far from a drug.
A*y
7 楼
Surprised that it will never be a drug?
Repeat after me PGC-1, PGC-1, PGC-1....
Not so many big bull ever has drug on the market. The ones who have drug on
the market are usually very low key (never mentioned on here). Do you know
there is a professor getting 20 million a year for his drug and that's only
0.5% of the drug's revenue.
【在 y****i 的大作中提到】
: you will be surprised.
Repeat after me PGC-1, PGC-1, PGC-1....
Not so many big bull ever has drug on the market. The ones who have drug on
the market are usually very low key (never mentioned on here). Do you know
there is a professor getting 20 million a year for his drug and that's only
0.5% of the drug's revenue.
【在 y****i 的大作中提到】
: you will be surprised.
y*i
8 楼
If you have read the paper, you will know this is not about PGC1a at all.
You will be surprised how fast this thing is moving.
on
know
only
【在 A******y 的大作中提到】
: Surprised that it will never be a drug?
: Repeat after me PGC-1, PGC-1, PGC-1....
: Not so many big bull ever has drug on the market. The ones who have drug on
: the market are usually very low key (never mentioned on here). Do you know
: there is a professor getting 20 million a year for his drug and that's only
: 0.5% of the drug's revenue.
You will be surprised how fast this thing is moving.
on
know
only
【在 A******y 的大作中提到】
: Surprised that it will never be a drug?
: Repeat after me PGC-1, PGC-1, PGC-1....
: Not so many big bull ever has drug on the market. The ones who have drug on
: the market are usually very low key (never mentioned on here). Do you know
: there is a professor getting 20 million a year for his drug and that's only
: 0.5% of the drug's revenue.
A*y
9 楼
I read the paper. I am just seeing how fast he switches (although there is
another big bull switches subject like crazy, too). You do know that you
cannot fully protect an endogenous protein IP wise. The science is good, but how much money you can make is a completely different story.
【在 y****i 的大作中提到】
: If you have read the paper, you will know this is not about PGC1a at all.
: You will be surprised how fast this thing is moving.
:
: on
: know
: only
another big bull switches subject like crazy, too). You do know that you
cannot fully protect an endogenous protein IP wise. The science is good, but how much money you can make is a completely different story.
【在 y****i 的大作中提到】
: If you have read the paper, you will know this is not about PGC1a at all.
: You will be surprised how fast this thing is moving.
:
: on
: know
: only
g*f
10 楼
我对这个文章的 fig5d 有一些疑惑，首先是这个western blot 图的质量，感觉是信号
很弱，曝光很长时间得来的，希望不是play around photoshop 弄出来的，姑且信它吧
，那么 3week exercise 后并没有那种很高很高的表达，而且control也有一定的
irisin 表达啊，这么能说明是excise 后的irisin 起作用了呢？
很弱，曝光很长时间得来的，希望不是play around photoshop 弄出来的，姑且信它吧
，那么 3week exercise 后并没有那种很高很高的表达，而且control也有一定的
irisin 表达啊，这么能说明是excise 后的irisin 起作用了呢？
s*e
11 楼
Fig.3的data全是另加的FNDC5吧？为什么全长的而不是irisin就可以browning呢？
in
【在 t*d 的大作中提到】
: 真是有钱人会更有钱
: Exercise benefits a variety of organ systems in mammals, and some of the
: best-recognized effects of exercise on muscle are mediated by the
: transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we
: show in mouse that PGC1-α expression in muscle stimulates an increase in
: expression of FNDC5, a membrane protein that is cleaved and secreted as a
: newly identified hormone, irisin. Irisin acts on white adipose cells in
: culture and in vivo to stimulate UCP1 expression and a broad program of
: brown-fat-like development. Irisin is induced with exercise in mice and
: humans, and mildly increased irisin levels in the blood cause an increase in
in
【在 t*d 的大作中提到】
: 真是有钱人会更有钱
: Exercise benefits a variety of organ systems in mammals, and some of the
: best-recognized effects of exercise on muscle are mediated by the
: transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we
: show in mouse that PGC1-α expression in muscle stimulates an increase in
: expression of FNDC5, a membrane protein that is cleaved and secreted as a
: newly identified hormone, irisin. Irisin acts on white adipose cells in
: culture and in vivo to stimulate UCP1 expression and a broad program of
: brown-fat-like development. Irisin is induced with exercise in mice and
: humans, and mildly increased irisin levels in the blood cause an increase in
b*0
12 楼
说说自己的看法。
这是用血清做western blot,加上irisin是新蛋白，应该抗体还不那么优化，有这个效
果是不是可以接受了？
后续的实验不是验证了irisin的作用了吗？Fig6
【在 g*******f 的大作中提到】
: 我对这个文章的 fig5d 有一些疑惑，首先是这个western blot 图的质量，感觉是信号
: 很弱，曝光很长时间得来的，希望不是play around photoshop 弄出来的，姑且信它吧
: ，那么 3week exercise 后并没有那种很高很高的表达，而且control也有一定的
: irisin 表达啊，这么能说明是excise 后的irisin 起作用了呢？
这是用血清做western blot,加上irisin是新蛋白，应该抗体还不那么优化，有这个效
果是不是可以接受了？
后续的实验不是验证了irisin的作用了吗？Fig6
【在 g*******f 的大作中提到】
: 我对这个文章的 fig5d 有一些疑惑，首先是这个western blot 图的质量，感觉是信号
: 很弱，曝光很长时间得来的，希望不是play around photoshop 弄出来的，姑且信它吧
: ，那么 3week exercise 后并没有那种很高很高的表达，而且control也有一定的
: irisin 表达啊，这么能说明是excise 后的irisin 起作用了呢？
b*0
13 楼
猜测这个实验应该是在Irisin鉴定出之前做的。直接用的是FNDC5.
irisin也有browning的效果，见fig6
【在 s*******e 的大作中提到】
: Fig.3的data全是另加的FNDC5吧？为什么全长的而不是irisin就可以browning呢？
:
: in
irisin也有browning的效果，见fig6
【在 s*******e 的大作中提到】
: Fig.3的data全是另加的FNDC5吧？为什么全长的而不是irisin就可以browning呢？
:
: in
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