KEGG链接的保守性大概多少？ - 未名空间MITBBS历史存档

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KEGG链接的保守性大概多少？

KEGG链接的保守性大概多少？# Biology - 生物学

Q*A2012-10-13 07:10

1 楼

Q最近频繁闹出门。
这个周末折腾了两天~~~~，除了睡觉，就一直在叫。守在门口叫，在客厅边巡逻边有一
搭没一搭的叫；我紧紧楼着他，希望它消停会，结果，人家是消停了-----睡着了-----
可睡醒了又继续叫；精神好就嗷嗷叫，精神不好就哼哼叫。。。还跳起来开门。。。。
。。我头疼死了！！！！

l*o2012-10-13 07:10

2 楼

过一个月能直接cancel 带回国用么？是不是还要unlock?
有人知道么？

N*n2012-10-13 07:10

3 楼

都知道细胞内pathway是动态的，KEGG是一个静态的链接，可能不同的时间，不同的细
胞，有的链接就不functional.
问题是大概有多少的保守性？比如breast cancer里面，大概10-20%的KEGG 链接可以
找到？

s*d2012-10-13 07:10

4 楼

同问at&t的，要是不能unlock我就cancel了

N*n2012-10-13 07:10

5 楼

A total of 90 KEGG pathways were broken down into over 130 million extensive
linear subpathways that considered all multiple gene assignments. Among
these subpathways, 4,644 well-defined subpathways were identified and their
significance evaluated via permutation tests. Subsequently, text-mining
association analysis was performed for the selected significant well-defined
subpathways
From;Pathway-Based Evaluation in Early Onset Colorectal Cancer Suggests
Focal Adhesion and Immunosuppression along with Epithelial-Mesenchymal
Transition
这篇文章说用microarray on colorectal cancer, 大概有5%左右的可以被证实。如果
考虑microarray或者方法的sensitivity, 至少大概10-20%的edge，或者基因之间的连
接可以确认。
但是这个数字有好像太低了，因为KEGGpathway的保守性，一般认为都要大约60%左右的
conservation
不知道大家有没有这方面的经验。

l*o2012-10-13 07:10

6 楼

贴个刚才跟verizon客服的对话
I do have a couple of questions, the order confirmtion said the sim card is
embeded, does that mean there is no sim card slot on the iphone?
Angel M: Correct.
You: so that means the iphone is locked to verizon?
Angel M: It is unlocked and the sim can be accessed, just not by customers.
You: I understand verizon is CDMA?
You: so if I want to take it overseas and use on GSM network, it will not
work?
Angel M: Verizon is CDMA but we are also GSM compatible. So it will work.
You: but since you said there is not sim card slot in the iphone, how can I
put foreign carrier's sim card into the phone?
Angel M: they will be able to. I believe there's a pop out slot maybe, but
from what I was told, it's something only a professional should try to
access.
这个我该怎么理解阿。。到底能不能换sim card..

l*12012-10-13 07:10

7 楼

Pls try KASS
http://www.genome.jp/tools/kaas/
more pls go to
http://elbo.gs.washington.edu/links.html
Then to
Metabolic Networks - Databases and Tools:
» KAAS
» iPath Left Icon click it

H*32012-10-13 07:10

8 楼

当你是小白。
所谓的professional service就是用一个曲别针捅一下

is

【在 l****o 的大作中提到】

: 贴个刚才跟verizon客服的对话
: I do have a couple of questions, the order confirmtion said the sim card is
: embeded, does that mean there is no sim card slot on the iphone?
: Angel M: Correct.
: You: so that means the iphone is locked to verizon?
: Angel M: It is unlocked and the sim can be accessed, just not by customers.
: You: I understand verizon is CDMA?
: You: so if I want to take it overseas and use on GSM network, it will not
: work?
: Angel M: Verizon is CDMA but we are also GSM compatible. So it will work.

H*32012-10-13 07:10

9 楼

全价买的当然可以cancel
Verizon是三网通吃，根据iphone5的经验，不需要unlock，回国后随便那家运营商都可
以用。

【在 l****o 的大作中提到】

: 过一个月能直接cancel 带回国用么？是不是还要unlock?
: 有人知道么？

l*o2012-10-13 07:10

10 楼

那这个embedded sim card怎么理解？verizon本身的sim card拿不出来？

a*72012-10-13 07:10

11 楼

it can be taken out of the phone. no worry.
I have a verizon iphone 5. there is a verizon sim card in the slot. And I
just replaceed it with Chinese GSM sim card when I was travelling in China,
no
problem even I was still in 2 years contract.

【在 l****o 的大作中提到】

: 那这个embedded sim card怎么理解？verizon本身的sim card拿不出来？

l*o2012-10-13 07:10

12 楼

Cool!
楼上也在korea univ. 呆过？

a*72012-10-13 07:10

13 楼

Yes
I have been there before

【在 l****o 的大作中提到】

: Cool!
: 楼上也在korea univ. 呆过？