请大侠们解说一下α-Tocopherol acetate如何抗氧化的？它与α-tocopheryl succinate之间的不同之处？ - 未名空间MITBBS历史存档

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请大侠们解说一下α-Tocopherol acetate如何抗氧化的？它与α-tocopheryl succinate之间的不同之处？

请大侠们解说一下α-Tocopherol acetate如何抗氧化的？它与α-tocopheryl succinate之间的不同之处？# Biology - 生物学

m*e2013-06-06 07:06

1 楼

I already have EAD card but my I-485 is pending. in this cituation,
do you think it will be fine if I change my job from research to nurse?
if after I change my job to nurse, my I-485 is denied, what I can do?
Many thanks for your suggestions in advance.
All my best

T*y2013-06-06 07:06

2 楼

J*u2013-06-06 07:06

3 楼

If your I-140 was approved over 180 days, for sure you can change your job
from one to another ! that is to say you old boss won't be able to stop your
green card processing!

A*y2013-06-06 07:06

4 楼

They are redox modulating agent. Chemically, they do not have any anti-
oxidant activity because they are fully oxidized. Biologically,
tocotrienols are way stronger redox modulating molecules than tocopherols.
Go google Edison pharmaceutical and their compounds, it looks like work in
human. However, I can tell you the mechanism(s) and molecular targets are
unknown.

l*i2013-06-06 07:06

5 楼

需要是同一类型的工作

【在 m*****e 的大作中提到】

: I already have EAD card but my I-485 is pending. in this cituation,
: do you think it will be fine if I change my job from research to nurse?
: if after I change my job to nurse, my I-485 is denied, what I can do?
: Many thanks for your suggestions in advance.
: All my best

T*y2013-06-06 07:06

6 楼

Hi ArtyArty,
Is there any difference between α-Tocopherol-acetate and α-tocopheryl
succinate on their redox modulation? Thank you so much!
Tankcity

h*o2013-06-06 07:06

7 楼

acetate只是增加了bioavailability以及shelf life
实际原理和vitaminE是一样的
http://www.cnsforum.com/imagebank/item/MOA_VITE/default.aspx

T*y2013-06-06 07:06

8 楼

一般认为α-Tocopherol-acetate 在体内或细胞内可转化为α-Tocopherol从而发挥
antioxidant的作用。不知道α-tocopheryl succinate是否也可以可转化为α-
Tocopherol？如果可以的话，为什么α-tocopheryl succinate的生物学作用与α-
Tocopherol和α-Tocopherol-acetate 又有很大不同？

A*y2013-06-06 07:06

9 楼

Because both acetate and succinate are also mitochondrial substrates. For
example, I think succinate protects kidney cells from oxidative injury ex
vivo. Acetate could do they same thing. Yes, both of them will get
converted to tocopherol. Btw, tocopherol is the bad vitamin E. It is the
one has been shown to increase your prostate cancer rate. If you really
want to protect cells, try tocotrienol. You will realize it is at least 10
to 100 times stronger. The drug Edison pharmaceutical trying to push through
is the metabolites of tocopherol and tocotrienol.

【在 T******y 的大作中提到】

: 一般认为α-Tocopherol-acetate 在体内或细胞内可转化为α-Tocopherol从而发挥
: antioxidant的作用。不知道α-tocopheryl succinate是否也可以可转化为α-
: Tocopherol？如果可以的话，为什么α-tocopheryl succinate的生物学作用与α-
: Tocopherol和α-Tocopherol-acetate 又有很大不同？

T*y2013-06-06 07:06

10 楼

It is at least 10 to 100 times stronger. Do you know this different effect
between tocopherol and tocotrienol came from in vitro or in vivo study?
What's the mechanism? How to prove it? For example, there are similar
antioxidant effects between 1 uM tocotrienol and 10 or 100 uM Tocopherol.
Thanks!

A*y2013-06-06 07:06

11 楼

Sorry, I can not tell you. If I know the mechanism, it will be amazing. I
have some hypothesis, but I don't have data to support it. It is my next
R01 actually (not on vitamin E though but on a similar vitamin).

【在 T******y 的大作中提到】

: It is at least 10 to 100 times stronger. Do you know this different effect
: between tocopherol and tocotrienol came from in vitro or in vivo study?
: What's the mechanism? How to prove it? For example, there are similar
: antioxidant effects between 1 uM tocotrienol and 10 or 100 uM Tocopherol.
: Thanks!

T*y2013-06-06 07:06

12 楼

ArtyArty,
Actually, you have told me a lot of things. I am concerning for it because I
have gotten some different results from α-Tocopherol-acetate and α-
tocopheryl succinate. This is a new field for me. I am struglling and trying
to understand them. Anyway, Thank you so much!
Tankcity

H*e2013-06-06 07:06

13 楼

Here are some information that may be interesting to you. But you need to
check the literature yourself since I heard most of them from a friend
working on it.
1. Acetate-T is the synthesized form that chemist believe will be
bioavailable. If you can find some PK/PD data, it will be believable. Succi
-T is the so-called conjugated form in vivo, a product by Phase I and II
enzymes. Many chemicals will be converted to this kind of form in liver to
further process. I am not sure what kind of experiment, in vivo or in vitro
, that you did and found difference. In vitro, cell can cut off Acetate.
Succi need enzyme in Kidney or liver to cut off; in vitro may not work.
2. a-T increase prostate cancer in recent trial but the conclusion is based
on a very small but statistically significant number. There is no
experimental evidence to support it. So, generally, a-T is not so good.
3. The purity of chemicals that you used may be another issue. Tocopherols
have other isoforms and some of them may have stronger anti-oxidant activity
and anti-cancer activity too. A well respective Chinese scientist CSYang
in New Jersey working on it. I am not sure what his relationship with the
company in Edison. Maybe you should search whether he has any good papers.
I am not in this field and do not know his work. Met him once in AACR
meeting 3 years ago and still remember him surrouded by many Chinese. Only
heard people say that he supported Chinese research many years ago and also
supported young Chinese a lot. So I am keeping his card on my desk.
4. Tocotrienols have some toxicity. I actually not sure what exactly
difference between toxicity and anti-cancer activity in this case.

T*y2013-06-06 07:06

14 楼

HGTPase,
Your information is very important to me. I will check the publications of
CSYang. I have worked 4 years at New Jersy and almost visited Edison at
every weekend when I lived there. It is so nice to meet with you at mitbbs.
I am working on a chemical regeant. This reagent could induce ROS generation
and caused cell death in cultured cell. Both alpha-tocopherol and alpha-
tocotrienol could rescue cell death. Acetate-T, not Succi-T, plays a similar
role as alpha-tocopherol. I am wondering why Succi-T dose not play a role?
BTW, Do you know wich kind of enzyme in Kidney or liver to cut off Succi-T?
Tankcity

A*y2013-06-06 07:06

15 楼

It probably have to do with pro-drug activation for the difference in succi
and acetate-T. Btw, the Edison pharmaceutical is located in San Francisco.
The guy is Guy Miller, you can pubmed him. CSYang is doing tocopherol last
time I talked to him. Although, he mentioned that his lab is also looking
at tocotrienol. As for the cancer study, Yang said the clinical trial that
increased prostate cancer incident was done poorly. The trial used wrong
tocopherol and wrong form of selenium.

of
generation
similar
?
?

【在 T******y 的大作中提到】

: HGTPase,
: Your information is very important to me. I will check the publications of
: CSYang. I have worked 4 years at New Jersy and almost visited Edison at
: every weekend when I lived there. It is so nice to meet with you at mitbbs.
: I am working on a chemical regeant. This reagent could induce ROS generation
: and caused cell death in cultured cell. Both alpha-tocopherol and alpha-
: tocotrienol could rescue cell death. Acetate-T, not Succi-T, plays a similar
: role as alpha-tocopherol. I am wondering why Succi-T dose not play a role?
: BTW, Do you know wich kind of enzyme in Kidney or liver to cut off Succi-T?
: Tankcity

H*e2013-06-06 07:06

16 楼

Sorry I cannot answer your question because most of my information are from
communication with PK/PD friends. I am in the cell signaling and
cytoskeleton related field. I even no idea what exactly are Phase I and II
enzyme. Arty knows Yang, you may contact him. As I recall, he is a nice
person and very supportive senior leader. Also, sorry about Edison. I
stopped by Edison on I-95 for gas and lunch. I saw the big sign of Rutgers
University. So those things come out of my mind. Did not really know
Edison chemical is in San F.

of
generation
similar
?
?

【在 T******y 的大作中提到】