Stem Cell was first identified in 1953,like DNA# Biology - 生物学
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http://www.ascb.org/ascbpost/index.php/ascbpost-home/item/59-th
The year 1953 is generally considered the year zero for molecular cell
biology with the publication of Watson and Crick's celebrated Nature paper
on the structure of DNA. But there was another big paper in 1953 by Yves
Clermont and Charles Leblond of McGill University that appeared in the
American Journal of Anatomy. It contained a discovery nearly on the order
with that of DNA. Working in the rat testes, Clermont and Leblond described
a population of undifferentiated cells that divided to produce spermatozoa
but also to maintain their own undifferentiated ranks. The researchers
called them "stem cells" and their hypothesis the "stem cell renewal theory.
" Unlike DNA, Leblond's theory of "plentipotent" stem cells met a storm of
criticism but in the fullness of time, "stem cells" turned out to be real
and the hypothesis correct. Few researchers cite 60-year-old papers but if
stem cells scientists were still crediting Clermont Y & Leblond CP, Renewal
of spermatogonia in the rat, its 60-year impact factor would be off the
charts.
In Montreal, McGill's Department of Anatomy & Cell Biology has put up a page
to mark the 60th anniversary of the stem cell renewal theory paper. Leblond
had a very long and extraordinary professional life (he died at 97 in 2007)
. We can only refer the curious to Wikipedia for a quick summary. Leblond
was also an early and influential member of the ASCB. He joined in 1963,
served on Council from 1969 to 1971, and received the E.B. Wilson Medal, the
ASCB's highest scientific award, in 1982.
The year 1953 is generally considered the year zero for molecular cell
biology with the publication of Watson and Crick's celebrated Nature paper
on the structure of DNA. But there was another big paper in 1953 by Yves
Clermont and Charles Leblond of McGill University that appeared in the
American Journal of Anatomy. It contained a discovery nearly on the order
with that of DNA. Working in the rat testes, Clermont and Leblond described
a population of undifferentiated cells that divided to produce spermatozoa
but also to maintain their own undifferentiated ranks. The researchers
called them "stem cells" and their hypothesis the "stem cell renewal theory.
" Unlike DNA, Leblond's theory of "plentipotent" stem cells met a storm of
criticism but in the fullness of time, "stem cells" turned out to be real
and the hypothesis correct. Few researchers cite 60-year-old papers but if
stem cells scientists were still crediting Clermont Y & Leblond CP, Renewal
of spermatogonia in the rat, its 60-year impact factor would be off the
charts.
In Montreal, McGill's Department of Anatomy & Cell Biology has put up a page
to mark the 60th anniversary of the stem cell renewal theory paper. Leblond
had a very long and extraordinary professional life (he died at 97 in 2007)
. We can only refer the curious to Wikipedia for a quick summary. Leblond
was also an early and influential member of the ASCB. He joined in 1963,
served on Council from 1969 to 1971, and received the E.B. Wilson Medal, the
ASCB's highest scientific award, in 1982.