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The crisis in medical research. And how to fix it
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The crisis in medical research. And how to fix it# Biology - 生物学
c*n
1
美国不好买豆花,而且自己也偷懒没试着做一下豆花,虽然点豆花的用料买了都快一
万年了哟。嫩豆腐用来做这道菜,也是非常入味的,可能叫香辣豆腐鱼更合适。个人觉
得用豆腐更好,因为豆腐可以放汤汁里面煮到入味,跟鱼片一起,很下饭哦。
果然吃货好打发,一个豆花鱼,就让心情至少有了两个小时的大逆转,挺好。借用了
小觅的方子,很好用哈!
香辣豆花鱼:
材料:swai鱼一片;嫩豆腐半盒;姜蒜适量切丝,葱绿切段,葱白切段;干辣椒干花椒
粒适量;柴火辣椒面适量,花椒面适量;郫县豆瓣一勺。
做法:
1. 将鱼片成鱼片,放料酒,盐,白胡椒,玉米淀粉拌匀,腌制30分钟。豆腐切成薄片
。姜蒜切丝,葱切段,葱白葱绿分开。干辣椒掰成小段。
2. 锅中加油烧热,下干辣椒段和干花椒粒爆香后,下郫县豆瓣炒出红油。
3. 加入姜蒜丝,葱白炒出香味。
4. 加入大概一杯多开水,加入生抽,盐,糖调味,烧开,下豆腐煮约3分钟入味。
5. 将鱼片铺在豆腐上,水量刚好没过鱼片为佳。煮至鱼片从透明变白即可。
6. 将煮好的鱼片豆腐连汤汁一同倒入碗中,根据自己口味撒上花椒面和辣椒面,并放
上葱绿。
7. 少量植物油烧热,浇在菜上即可。
avatar
c*r
2
Recent US government budgets have harmed the National Institutes of Health.
But the problems in the medical research system are deeper than just the
current budget. If you care about medical research, read this article in the
Proceedings of the National Academy of Sciences by Bruce Alberts, Marc
Kirschner, Shirley Tilghman, and Harold Varmus.
Alberts and his colleagues describe a hypercompetitive culture in science
that undermines the process of discovery.
Competition… has always been a part of the scientific enterprise, and
it can have positive effects. However, hypercompetition for the resources
and positions that are required to conduct science suppresses the creativity
, cooperation, risk-taking, and original thinking required to make
fundamental discoveries… biomedical scientists are spending far too much of
their time writing and revising grant applications and far too little
thinking about science and conducting experiments.
You probably expect that the next sentence will be, “So give us more money.
” But that’s not where they go.
We believe that the root cause of the wide-spread malaise is a
longstanding assumption that the biomedical research system in the United
States will expand indefinitely at a substantial rate. We are now faced with
the stark realization that this is not the case.
Assuming that science will expand forever, senior scientists have trained
far more junior scientists than the system can support, leading to
hypercompetition.
The mismatch between supply and demand can be partly laid at the feet of
the discipline’s Malthusian traditions. The great majority of biomedical
research is conducted by aspiring trainees: by graduate students and
postdoctoral fellows. As a result, most successful biomedical scientists
train far more scientists than [there are] relevant positions in academia,
government, and the private sector.
The overproduction of new scientists is driven by “perverse incentives”:
Salaries paid by grants are subject to indirect cost reimbursement,
creating a strong incentive for universities to enlarge their faculties by
seeking as much faculty salary support as possible on government grants.
This has led to an enormous growth in “soft money” positions, with
stagnation in the ranks of faculty who have institutional support. The
government is also indirectly paying for the new buildings to house these
scientists by allowing debt service on new construction to be included in
its calculations of indirect cost recovery.
Alberts et al. have detailed suggestions for reform. They write
(i) to advocate for predictable budgets for US funding agencies and for
an altered composition of the research workforce, both with the aim of
making the research environment sustainable; (ii) to rebalance the research
portfolio by recognizing the inertia that favors large projects and by
improving the peer review system so that more imaginative, long-term
proposals are being funded and scientific careers can have a more stable
course; and (iii) to encourage changes in governmental policies that now
have the unintended consequence of promoting excessive, unsustainable growth
of the US biomedical research enterprise.
I cannot overstate how distinguished these authors are, both as researchers
and institutional leaders in science. Alberts made discoveries in how
chromosomes replicate during cell division, is the former editor of Science,
and former President of the National Academy of Sciences. Kirschner made
discoveries in developmental biology and is a University Professor at
Harvard, where he served as chair of the departments of systems biology and
developmental biology. Tilghman made discoveries in gene regulation and is
the former President of Princeton. Varmus won the Nobel Prize for
discovering retroviral oncogenes. He is the former director of the NIH,
former President of the Memorial Sloan-Kettering Cancer Center, and the
current director of the National Cancer Institute.
Get it? It’s as if the Pope and three leading cardinals held a press
conference predicting the collapse of the Catholic church. These people know
what they are talking about and we need to listen.
avatar
w*o
3
好香!
avatar
T*i
4
很多牛人说了多少次了,有用吗?多少人的利益在里面,改革难啊。反正有中印两国的
学生不停往里填坑,就算死了,上面的人也不会在乎。至于影响科学发展,大多数人在
乎吗?除非有另外一个国家,科学发展水平大幅超过美国。不过要真有那一天,美国也
早堕落成第三世界了。

.
the
creativity

【在 c*******r 的大作中提到】
: Recent US government budgets have harmed the National Institutes of Health.
: But the problems in the medical research system are deeper than just the
: current budget. If you care about medical research, read this article in the
: Proceedings of the National Academy of Sciences by Bruce Alberts, Marc
: Kirschner, Shirley Tilghman, and Harold Varmus.
: Alberts and his colleagues describe a hypercompetitive culture in science
: that undermines the process of discovery.
: Competition… has always been a part of the scientific enterprise, and
: it can have positive effects. However, hypercompetition for the resources
: and positions that are required to conduct science suppresses the creativity

avatar
d*y
5
不错
avatar
r*1
6
mark下,周末做
avatar
d*a
7
很诱人。。。
avatar
w*c
9
楼主,花椒哪里买呀?
avatar
c*n
10
我花椒国内带来的家乡花椒。这边能买到的汉源花椒也不错呢

楼主,花椒哪里买呀?

【在 w*******c 的大作中提到】
: 楼主,花椒哪里买呀?
avatar
c*n
11
美国不好买豆花,而且自己也偷懒没试着做一下豆花,虽然点豆花的用料买了都快一
万年了哟。嫩豆腐用来做这道菜,也是非常入味的,可能叫香辣豆腐鱼更合适。个人觉
得用豆腐更好,因为豆腐可以放汤汁里面煮到入味,跟鱼片一起,很下饭哦。
果然吃货好打发,一个豆花鱼,就让心情至少有了两个小时的大逆转,挺好。借用了
小觅的方子,很好用哈!
香辣豆花鱼:
材料:swai鱼一片;嫩豆腐半盒;姜蒜适量切丝,葱绿切段,葱白切段;干辣椒干花椒
粒适量;柴火辣椒面适量,花椒面适量;郫县豆瓣一勺。
做法:
1. 将鱼片成鱼片,放料酒,盐,白胡椒,玉米淀粉拌匀,腌制30分钟。豆腐切成薄片
。姜蒜切丝,葱切段,葱白葱绿分开。干辣椒掰成小段。
2. 锅中加油烧热,下干辣椒段和干花椒粒爆香后,下郫县豆瓣炒出红油。
3. 加入姜蒜丝,葱白炒出香味。
4. 加入大概一杯多开水,加入生抽,盐,糖调味,烧开,下豆腐煮约3分钟入味。
5. 将鱼片铺在豆腐上,水量刚好没过鱼片为佳。煮至鱼片从透明变白即可。
6. 将煮好的鱼片豆腐连汤汁一同倒入碗中,根据自己口味撒上花椒面和辣椒面,并放
上葱绿。
7. 少量植物油烧热,浇在菜上即可。
avatar
w*o
12
好香!
avatar
d*y
13
不错
avatar
r*1
14
mark下,周末做
avatar
d*a
15
很诱人。。。
avatar
w*c
17
楼主,花椒哪里买呀?
avatar
c*n
18
我花椒国内带来的家乡花椒。这边能买到的汉源花椒也不错呢

楼主,花椒哪里买呀?

【在 w*******c 的大作中提到】
: 楼主,花椒哪里买呀?
avatar
i*t
19
郫县豆瓣 哪里有卖?
鱼 有啥选择吗
avatar
t*e
20
赞水平高!
有专业风范

【在 c********n 的大作中提到】
: 我花椒国内带来的家乡花椒。这边能买到的汉源花椒也不错呢
:
: 楼主,花椒哪里买呀?

avatar
c*n
21
鹃城比丹丹牌的多一些,亚洲店一般都有。水煮鱼类我喜欢用swai,烤的话我用
tilapia

郫县豆瓣 哪里有卖?鱼 有啥选择吗

【在 i******t 的大作中提到】
: 郫县豆瓣 哪里有卖?
: 鱼 有啥选择吗

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