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问个问题,怎样分析两个drug是否有synergistic effect
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问个问题,怎样分析两个drug是否有synergistic effect# Biology - 生物学
n*e
1
http://www.myvisajobs.com/Reports/Green-Card-2011.aspx?T=CT
老印是我们十倍,南韩都比我们多
2011 Green Card Report: Top Citizenship Country
1 - 50 | 51 - 100 | 101 - 150 | 151 - 200
Category: All | Case Status | Country | Visa | Job Title | Occupation | Industry | Sector | Work City | Work State
Rank Citizenship Country Green Card Petitions Average Salary
1 India 31,978 $85,043
2 South Korea 5,296 $58,094
3 Mexico 4,927 $40,592
4 China 4,553 $75,799
5 Canada 4,121 $97,979
6 Philippines 3,916 $54,535
7 United Kingdom 1,533 $96,293
8 Pakistan 1,382 $90,558
9 Taiwan 1,356 $65,106
10 Ecuador 1,185 $40,483
11 Japan 1,067 $64,688
12 Brazil 1,062 $65,413
13 Colombia 819 $67,128
14 Turkey 817 $78,334
15 Venezuela 801 $72,773
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z*a
2
Leahy提出来的
MDM13298
Purpose: To amend the Immigration and Nationality Act
to eliminate discrimination in the immigration laws by
permitting permanent partners of United States citizens
and lawful permanent residents to obtain lawful perma-
nent resident status in the same manner as spouses
of citizens and lawful permanent residents and to penal-
ize immigration fraud in connection with permanent
partnerships.
MDM13374
Purpose: To recognize, for purposes of the Immigration and
Nationality Act, any marriage entered into in full compliance
with the laws of the State or foreign country
within which such marriage was performed.
IN
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h*n
3
嗯,还是问short sale的房子,本来的打算是做了Inspection后,如果发现有些小问题
的话,就自己认了,因为卖家说“as is”,他们没钱修任何地方的。不过最近做了些功
课,盘算着修这修那,发现钱不够用啊,那我可以拿着inspection 的结果向银行再还点
价来修不?比方说,要银行再将2万房价,可以不?听人说是可以的,不过我担心银行
会不会一怒之下不卖我了。
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m*y
4
这个版上工作的人多,求 HELP ~~~
我回复了这封信以后 这家公司2天都再没动静了。
是不是我被客套的发了封warning信,然后被无情的拒了
We have determined that the person we hire must be available to begin
working full time in Los Angeles on or before May 1 and continue through the
end of August.
We are not planning to pay relocation or living expenses. If you can get set
up in L.A. meet these time requirements, please let us know.
真是期盼实习啊。
要是您觉得按时间上来看 他拒了我 您直说
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u*s
5
两个药都抑制细胞生长,然后做了不同浓度的单一和两个药的组合,记录细胞生长,请
问应该怎样分析是否有synergistic effect?谢谢!
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b*d
6
应该是吧.这老贼果然提了.就看durbin and shcumer能不能守信,在markup时候,投票反
对这个修正案.
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D*9
7
you can terminate the contract if inspection result is not good
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m*y
8
是不是这个不算个问题。。。。。
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s*x
9
唯一校准就是effect 是否 addictive。
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s*c
10
这个烂货
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h*n
11
嗯,主要是想还点价,就好有钱修房子了,又担心银行不卖我了。有人有过类似经历吗?

【在 D****9 的大作中提到】
: you can terminate the contract if inspection result is not good
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h*o
12
1+1 >2 ?
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j*n
14

这个免费的Synstat可以用一下 不过要仔细阅读下manual
http://www.umgcc.org/research/biostat_software.htm

【在 u***s 的大作中提到】
: 两个药都抑制细胞生长,然后做了不同浓度的单一和两个药的组合,记录细胞生长,请
: 问应该怎样分析是否有synergistic effect?谢谢!

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l*c
15
This is so called "poison bill" that kills the bill.
Some republicans welcome this.

【在 z******a 的大作中提到】
: Leahy提出来的
: MDM13298
: Purpose: To amend the Immigration and Nationality Act
: to eliminate discrimination in the immigration laws by
: permitting permanent partners of United States citizens
: and lawful permanent residents to obtain lawful perma-
: nent resident status in the same manner as spouses
: of citizens and lawful permanent residents and to penal-
: ize immigration fraud in connection with permanent
: partnerships.

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G*h
16
个人理解,不一定完整:
【背景】:
如果 2 药物(A、B)纯粹作用同一个药靶或者途径(not independent),那么“最大
”效果一致(maximum responses/effects)。这时候出现的是 additive effect。或
者说,在 A 里面加些 B 时候,也就是等于在 A 里面多加了些 A)。
另外情况是 A、B 作用为 independent to each other,或者 partially dependent(
这时应该不止一个药靶,但其中一个是吻合的)。
【如何检测】:
最简单合适的方法应该做 3 个 dose response 曲线(浓度从 0 到 最高):A、B、和
A+B combined。
然后看 A+B 的曲线,是否吻合 A 和 B 两个曲线的简单叠加,同时做个 significance
test。
1)等于叠加、或者几乎是叠加 = additive
2)显著地低于叠加 = negative synergy
3)显著地高于叠加 = positive synergy
也要考虑这3种情况的程度之分(效果好坏的程度)。
欢迎讨论和补充!
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p*a
17
but republicans can not vote yes this amendment otherwise they will lost
election.

【在 l****c 的大作中提到】
: This is so called "poison bill" that kills the bill.
: Some republicans welcome this.

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s*g
18
做个MTS或Apoptosis。
做 3 个 dose response 曲线(浓度从 0 到 最高):A、B、和
A+B combined。
A1
A2 (Half of A1)
A3 (Half of A2)
B1
B2 (_Half of B1)
B3 (Half of B2)
A1+B1
A2+B2
A3+B3
用软件( CALCUSYM ) 计算出是叠加,协同还是捷抗
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u*s
19
谢谢大家!具体怎么做还要好好看一下才能知道.
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f*r
20
有软件可以算系数,到达某个数值就是有效果

【在 u***s 的大作中提到】
: 两个药都抑制细胞生长,然后做了不同浓度的单一和两个药的组合,记录细胞生长,请
: 问应该怎样分析是否有synergistic effect?谢谢!

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