有了解昨天 FDA批准的bg-12的进来解释一下 (转载)# Chemistry - 化学
l*d
1 楼
配偶和孩子在国内待了大半年，配偶没有工作，是file married separately还是file
married jointly？如果是separately，配偶没工作并且大部分时间都在中国还需要
file tax return吗？
married jointly？如果是separately，配偶没工作并且大部分时间都在中国还需要
file tax return吗？
n*z
2 楼
请问好的找工作的猎头公司，谢谢！有朋友知道吗？能否告知一下联系方式？
m*u
3 楼
☆─────────────────────────────────────☆
smartdogwc (smartdog) 于 (Thu Jan 15 13:04:23 2009) 提到:
去了趟PEPBOY，要价九十刀，不知道是贵还是自己太CHEAP，请问现在是个什么行情，
大伙能不能推荐个铺子？是不是一般SAN GABRIEL那边的华人铺子一般便宜一些？
☆─────────────────────────────────────☆
TrueCabbage (犭者) 于 (Thu Jan 15 13:04:47 2009) 提到:
autozone, free
☆─────────────────────────────────────☆
clittle (be happy) 于 (Thu Jan 15 13:08:51 2009) 提到:
autozone已经不让查了, 那些garage把他们告了. 找个有仪器的老墨查吧
☆─────────────────────────────────────☆
smartdogwc (smartdog)
smartdogwc (smartdog) 于 (Thu Jan 15 13:04:23 2009) 提到:
去了趟PEPBOY，要价九十刀，不知道是贵还是自己太CHEAP，请问现在是个什么行情，
大伙能不能推荐个铺子？是不是一般SAN GABRIEL那边的华人铺子一般便宜一些？
☆─────────────────────────────────────☆
TrueCabbage (犭者) 于 (Thu Jan 15 13:04:47 2009) 提到:
autozone, free
☆─────────────────────────────────────☆
clittle (be happy) 于 (Thu Jan 15 13:08:51 2009) 提到:
autozone已经不让查了, 那些garage把他们告了. 找个有仪器的老墨查吧
☆─────────────────────────────────────☆
smartdogwc (smartdog)
i*a
4 楼
http://www.fatwallet.com/forums/hot-deals/1065374/
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Are We Done Yet & Daddy Day Camp (2 Disc)
Blue Streak & National Security (2 Disc) - 2 Pack
Coming To America & Trading Places (Best Buy Excl)
Crank & Crank 2 - 2 Pack
Defiance & Enemy At The Gates (Best Buy Exclusive)
Dirty Harry/Magnum Force - Widescreen Subtitle AC3
Dirty Harry/Magnum Force - Widescreen Subtitle AC3
Doomsday (2008) & End Of Days (2 Disc) - Widescreen
Enforcer & Sudden Impact
Fifth Element & Gattaca (2 Disc) - 2 Pack
First Knight & Knight'S Tale (2 Disc) - 2 Pack
First Sunday & Little Man (2 Disc)
Fletch & Bruce Almighty (2 Disc) - Widescreen
Frantic/Presumed Innocent - Subtitle Dolby
Funny Farm & Spies Like Us - Dubbed Subtitle Dolby Dts
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Grumpy Old Men/Grumpier Old Men - Fullscreen Subtitle
Hancock & Ghost Rider (2 Disc)
Hitch & Jerry Maguire (2 Disc)
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Kung Fu Hustle & One (2 Disc) - 2 Pack
Last Boy Scout & Last Man Standing - Subtitle Dolby Dts
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m*d
5 楼
看着倒算便宜
n*n
6 楼
【 以下文字转载自 Biology 讨论区 】
发信人: nnnnnnnnn (hv), 信区: Biology
标 题: 有了解昨天 FDA批准的bg-12的进来解释一下
发信站: BBS 未名空间站 (Thu Mar 28 15:11:54 2013, 美东)
富马酸二甲酯，
这么简单的药物，当初怎么发现的？
专利没有问题吗
发信人: nnnnnnnnn (hv), 信区: Biology
标 题: 有了解昨天 FDA批准的bg-12的进来解释一下
发信站: BBS 未名空间站 (Thu Mar 28 15:11:54 2013, 美东)
富马酸二甲酯，
这么简单的药物，当初怎么发现的？
专利没有问题吗
l*d
7 楼
急问
file
【在 l*****d 的大作中提到】
: 配偶和孩子在国内待了大半年，配偶没有工作，是file married separately还是file
: married jointly？如果是separately，配偶没工作并且大部分时间都在中国还需要
: file tax return吗？
file
【在 l*****d 的大作中提到】
: 配偶和孩子在国内待了大半年，配偶没有工作，是file married separately还是file
: married jointly？如果是separately，配偶没工作并且大部分时间都在中国还需要
: file tax return吗？
n*z
8 楼
请朋友们帮忙推荐几个好的猎头公司，谢谢！
J*e
9 楼
难怪今天股票暴涨
【在 n*******n 的大作中提到】
: 【 以下文字转载自 Biology 讨论区 】
: 发信人: nnnnnnnnn (hv), 信区: Biology
: 标 题: 有了解昨天 FDA批准的bg-12的进来解释一下
: 发信站: BBS 未名空间站 (Thu Mar 28 15:11:54 2013, 美东)
: 富马酸二甲酯，
: 这么简单的药物，当初怎么发现的？
: 专利没有问题吗
【在 n*******n 的大作中提到】
: 【 以下文字转载自 Biology 讨论区 】
: 发信人: nnnnnnnnn (hv), 信区: Biology
: 标 题: 有了解昨天 FDA批准的bg-12的进来解释一下
: 发信站: BBS 未名空间站 (Thu Mar 28 15:11:54 2013, 美东)
: 富马酸二甲酯，
: 这么简单的药物，当初怎么发现的？
: 专利没有问题吗
c*h
10 楼
you can choose either, but you may get more money back with MJ.
n*z
11 楼
请问好的找工作的猎头公司，谢谢！有朋友知道吗？能否告知一下联系方式？
n*n
12 楼
biogen idec 的吗？
l*d
13 楼
感谢您回复，我想补充一下，配偶和孩子在国内带了11个月零几天，也就是说去年年底
来的美国，去年在美国所住不到一个月，这样可以file jointly吗？
【在 c**h 的大作中提到】
: you can choose either, but you may get more money back with MJ.
来的美国，去年在美国所住不到一个月，这样可以file jointly吗？
【在 c**h 的大作中提到】
: you can choose either, but you may get more money back with MJ.
n*z
14 楼
请朋友们帮忙推荐几个好的猎头公司，谢谢！
p*u
15 楼
http://www.medpagetoday.com/Neurology/MultipleSclerosis/38122?i
Dimethyl fumarate has won FDA approval to treat relapsing-remitting forms of
multiple sclerosis and will be sold under the name Tecfidera, the agency
said Wednesday.
Manufactured by Biogen Idec, the drug is also known as BG-12. It becomes the
third oral disease-modifying medication available to treat MS. Others
include fingolimod (Gilenya) and teriflunomide (Aubagio).
Dimethyl fumarate has a novel mechanism of action relative to existing MS
drugs. It is believed to activate the nuclear factor-like 2 transcriptional
pathway, thereby reducing oxidative stress that contributes strongly to
demyelination.
The drug has also been used for many years in Europe and elsewhere to treat
psoriasis, and has also been used as a fungicide and desiccant in furniture
manufacture.
Two placebo-controlled phase III trials served as the basis for approval,
the agency said. Called DEFINE and CONFIRM, they enrolled a total of some 2,
700 patients. In addition to comparing the drug with placebo, CONFIRM
included a third arm with open-label glatiramer acetate (Copaxone), a
standard injectable MS drug.
Both trials demonstrated that dimethyl fumarate was superior to placebo in
preventing relapses and delaying disability progression. It also appeared to
be somewhat more effective than glatiramer acetate in CONFIRM.
The most common adverse effects were gastrointestinal complaints and
flushing. The FDA also noted that the drug carries a risk of lymphocytopenia
, although infections did not appear to be increased as a result in the
phase III studies.
"No drug provides a cure for multiple sclerosis so it is important to have a
variety of treatment options available for patients," said Russell Katz, MD
, director of the Division of Neurology Products in the FDA's Center for
Drug Evaluation and Research, in a statement announcing the approval.
A Biogen competitor, Teva Pharmaceuticals, had petitioned the FDA to hold an
advisory committee meeting on the drug before approving it, citing the
hematologic effects and other risks, but the agency declined to do so.
Dimethyl fumarate has won FDA approval to treat relapsing-remitting forms of
multiple sclerosis and will be sold under the name Tecfidera, the agency
said Wednesday.
Manufactured by Biogen Idec, the drug is also known as BG-12. It becomes the
third oral disease-modifying medication available to treat MS. Others
include fingolimod (Gilenya) and teriflunomide (Aubagio).
Dimethyl fumarate has a novel mechanism of action relative to existing MS
drugs. It is believed to activate the nuclear factor-like 2 transcriptional
pathway, thereby reducing oxidative stress that contributes strongly to
demyelination.
The drug has also been used for many years in Europe and elsewhere to treat
psoriasis, and has also been used as a fungicide and desiccant in furniture
manufacture.
Two placebo-controlled phase III trials served as the basis for approval,
the agency said. Called DEFINE and CONFIRM, they enrolled a total of some 2,
700 patients. In addition to comparing the drug with placebo, CONFIRM
included a third arm with open-label glatiramer acetate (Copaxone), a
standard injectable MS drug.
Both trials demonstrated that dimethyl fumarate was superior to placebo in
preventing relapses and delaying disability progression. It also appeared to
be somewhat more effective than glatiramer acetate in CONFIRM.
The most common adverse effects were gastrointestinal complaints and
flushing. The FDA also noted that the drug carries a risk of lymphocytopenia
, although infections did not appear to be increased as a result in the
phase III studies.
"No drug provides a cure for multiple sclerosis so it is important to have a
variety of treatment options available for patients," said Russell Katz, MD
, director of the Division of Neurology Products in the FDA's Center for
Drug Evaluation and Research, in a statement announcing the approval.
A Biogen competitor, Teva Pharmaceuticals, had petitioned the FDA to hold an
advisory committee meeting on the drug before approving it, citing the
hematologic effects and other risks, but the agency declined to do so.
l*d
16 楼
请问可以选择联合报税的理由是下面这样吗？
Nonresident aliens and dualstatus
aliens.
Generally, a married couple can't
file a joint return if either spouse is a
nonresident alien at any time during the
year. However, if you were a nonresident
alien or a dual-status alien and were
married to a U.S. citizen or resident alien
at the end of 2016, you can elect to
be treated as a resident alien and file a
joint return. See Pub. 519 for details.
【在 c**h 的大作中提到】
: you can choose either, but you may get more money back with MJ.
Nonresident aliens and dualstatus
aliens.
Generally, a married couple can't
file a joint return if either spouse is a
nonresident alien at any time during the
year. However, if you were a nonresident
alien or a dual-status alien and were
married to a U.S. citizen or resident alien
at the end of 2016, you can elect to
be treated as a resident alien and file a
joint return. See Pub. 519 for details.
【在 c**h 的大作中提到】
: you can choose either, but you may get more money back with MJ.
n*z
17 楼
初来乍到，请朋友帮忙推荐一下，谢谢！
f*y
19 楼
pub 519
If, at the end of your tax year, you are married and one spouse is a U.S.
citizen or a resident alien and the other spouse is a nonresident alien, you
can choose to treat the nonresident spouse as a U.S. resident. This
includes situations in which one spouse is a nonresident alien at the
beginning of the tax year, but a resident alien at the end of the year, and
the other spouse is a nonresident alien at the end of the year.
我是这样解读的, 只要你是resident alien(for tax purpse), 无论配偶在不在美国都
可以
joint filing
If, at the end of your tax year, you are married and one spouse is a U.S.
citizen or a resident alien and the other spouse is a nonresident alien, you
can choose to treat the nonresident spouse as a U.S. resident. This
includes situations in which one spouse is a nonresident alien at the
beginning of the tax year, but a resident alien at the end of the year, and
the other spouse is a nonresident alien at the end of the year.
我是这样解读的, 只要你是resident alien(for tax purpse), 无论配偶在不在美国都
可以
joint filing
n*z
20 楼
请问好的找工作的猎头公司，谢谢！有朋友知道吗？能否告知一下联系方式？
y*s
21 楼
this one is more interesting
http://seekingalpha.com/article/1299691-aubagio-eu-backing-come
http://aishealth.com/blog/pharmacy-benefit-management/genzyme-m
【在 n*******n 的大作中提到】
: biogen idec 的吗？
http://seekingalpha.com/article/1299691-aubagio-eu-backing-come
http://aishealth.com/blog/pharmacy-benefit-management/genzyme-m
【在 n*******n 的大作中提到】
: biogen idec 的吗？
n*z
22 楼
有朋友知道吗？谢谢！
A*y
23 楼
Never heard of Lyrica? VPA? Top sellers, no chemistry necessary. How about
Lithium...yum!
【在 n*******n 的大作中提到】
: biogen idec 的吗？
Lithium...yum!
【在 n*******n 的大作中提到】
: biogen idec 的吗？
r*u
24 楼
我很少发言，但是看到你很急，不知道怎么帮助你，猎头是要分领域的，你要先把自己
的情况说清楚，别人才能帮助你。
的情况说清楚，别人才能帮助你。
s*q
25 楼
一般神经系统的药物好象都是挺简单的小分子
【在 n*******n 的大作中提到】
: biogen idec 的吗？
【在 n*******n 的大作中提到】
: biogen idec 的吗？
A*4
26 楼
哎，看你那么着急，我也来说一句吧。
记住：猎头跟car dealer没有任何区别！！！！他们的本质就是sales!!!
我看你好像没什么找工作的经验，那你最好还是自己找吧，远离猎头比较好。
跟猎头打交道还是很需要点技巧的，否则你被别人卖了,还替别人数钱呢。
如果真要找猎头，把简历放在careerbuilder,monster上面，自然有猎头来找你。
Good luck!
记住：猎头跟car dealer没有任何区别！！！！他们的本质就是sales!!!
我看你好像没什么找工作的经验，那你最好还是自己找吧，远离猎头比较好。
跟猎头打交道还是很需要点技巧的，否则你被别人卖了,还替别人数钱呢。
如果真要找猎头，把简历放在careerbuilder,monster上面，自然有猎头来找你。
Good luck!
s*e
27 楼
Post resume on LinkedIn. If you are good, recruiter will call you.
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