【肖氏术最新消息】ACH的双盲随机对照肖氏手术实验正式启动
Iamback：
信誉死的惨败：ACH的双盲随机对照肖氏手术实验，正式启动
在3月份脊柱裂协会第二届世界大会上，ACH的医生宣布，双盲随机对照的肖氏反射弧临
床实验，20名病人已经招募到齐，IRB也批准了实验。
½ Detethering (D)
½ Detethering + Xiao Procedure (D + X)
(D + X) – D = X
这个临床实验，不过结果如何，都是在人类和疾病做斗争过程中值得探索的步骤。
可是，信誉死的恶棍们，千方百计阻扰这个临床实验的进行，写了很多黑函。
我记得，信誉死一次次宣布ACH的双盲随机对照试验被取消了。
他们阻扰科学进展的努力，犹如螳臂当车。
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Current Status of ACH Trials
All Children’s Hospital and Johns Hopkins Medicine
St. Petersburg, FL
Both IRB Approved
Randomized Spina Bifida Trial
Enrollment stopped: 20 patients total
Procedure can be safely performed as an adjunct to spinal cord detethering
procedure
Two more years of follow-up
Spinal Cord Injury Study
No further enrollment
Awaiting outcome of spina bifida study
若明：
更多的信息在这里
[www.sba-resource.org]
SECOND WORLD CONGRESS
ON SPINA BIFIDA RESEARCH & CARE
March 11–14, 2012
Cosmopolitan Hotel, Las Vegas, NV
另外去年4月All Children's 正式加入了 John Hopkins Medicine，成为JHHS的一员。
实验结果将更有说服力。
六指：
下月美国泌尿年会老昏的摘要
Tuesday, May 22, 2012 10:30 AM-12:30 PM
Urodynamics/Incontinence/Female Urology: Neurogenic Voiding Dysfunction
Moderated Poster
National Key Research Grant(973 project) of China
1661: A New Micturition Center in Pons after Xiao Procedure for Neurogenic
Bladder in Patients with spina bifida-An fMRI Study
Chuan-Guo Xiao
Huageng Liang
Bing Li
Wuhan, "China, People's Republic of"
Introduction and Objectives
A somatic-autonomic reflex procedure (Xiao Procedure) can result in
voluntary voiding control in Spina Bifida patients with neurogenic bladder (
Xiao, 2005,J.Urol). To clarify the underlying mechanism, an 7 year fMRI
study on brain micturition center was carried out.
Methods
Fourteen young adult patients with spina bifida and neurogenic bladder were
enrolled in a fMRI study on brain micturition center pre and post-Xiao
Procedure, compared with 13 healthy adult volunteers as normal control. The
experiment was performed on a 3T MR scanner (Philips, Achiva) for the
functional brain map and a high resolution T1-weighted scan.
Results
(1), The voiding activated regions for normal control group located in pons
and suprapontine structures including frontal cortex, PCG, CMA, SMA,
opercula, hypothalamus, thalamus, cerebellum and PAG ( fig1). _x000D_ _x000D
_ (2), The pre-operative group showed very few active regions associated
with voidingin the brain frontal cortex, occipital lobe and cerebellum (fig2
). _x000D_ _x000D_ (3), The post-operative group showed remarkable
differences from pre-operative group in voiding activated regions. The
active regions of post-operative group were similar to those in normal
control in suprapontine structures CMA, SMA, opercula, hypothalamus,
thalamus and cerebellum , with slight differences in occipital lobe and PCG.
There were also new, strong and consistent activations in pons, but the
locations were quite different from those in normal control group. (Fig. 3).
_x000D_ _x000D_ (4), The most important results were discovered in pons. No
activation was found in the pons in pre-operative patients even at p<0.05
uncorrected, while new, strong and consistent activations were recorded in
pons in post-operative group even at p<0.00001 uncorrected. Most
interestingly, the voiding activated regions in the pons of post-operation
group is obviously different form those in normal control (Fig4).
Conclusions
Xiao Procedure can result in brain functional reorganization for a new
voiding control center mainly in Pons of Spina Bifida patients.
