Re: MCBC 2nd paper (discussion/comment)# Biology - 生物学
M*e
1 楼
structural biology is pretty tough, particularly to get crystal for X-ray
analysis of static conformation. otherwise, NMR is used to analyze
conformation(s) in solution. this is my basic understanding of this
issue. this paper has addressed the crystal structure of mechano-
sensitive channel of small conductance (MscS ) at 3.9 angstroms
resolution (not very high). compared with MscL that has large
conductance, the MscS is also mechanosensitive, yet the opening
pressure is lower. MscS has more ex
analysis of static conformation. otherwise, NMR is used to analyze
conformation(s) in solution. this is my basic understanding of this
issue. this paper has addressed the crystal structure of mechano-
sensitive channel of small conductance (MscS ) at 3.9 angstroms
resolution (not very high). compared with MscL that has large
conductance, the MscS is also mechanosensitive, yet the opening
pressure is lower. MscS has more ex