c*a
2 楼
Nature Genetics Vol32, Oct,2002 p306P311
Human securin interacts with p53 and modulates p53-mediated transcriptional
activity and apoptosis.
The first report show the relevance between human securin and p53.
The gene PTTG1 is considered human securin gene which can inhibit
sister-chromatid separation in vertebrates, thus may contribute to cell-cycle
and tumorigenesis. The authors used phage display to identify the interaction
between hPTTG1 and p53, and they carried out a series of functional a
Human securin interacts with p53 and modulates p53-mediated transcriptional
activity and apoptosis.
The first report show the relevance between human securin and p53.
The gene PTTG1 is considered human securin gene which can inhibit
sister-chromatid separation in vertebrates, thus may contribute to cell-cycle
and tumorigenesis. The authors used phage display to identify the interaction
between hPTTG1 and p53, and they carried out a series of functional a
l*k
3 楼
This is a pretty cool paper,
1. The experiment they used to show securing binding of P53 affects ability of
P53 to bind DNA, I think it is a long shot to have that conclusion, there are
plenty of other alternative explanations. However, their in vivo experiments
are very convincing.
2. Can anyone tell me how many AA can phage display vectors successfully
express?
A recent paper by ES. Lander and TR. Golub in nature genetics (Jan 2003) “A
molecular signature of metastasis in primary solid tumors”
【在 c******a 的大作中提到】
: Nature Genetics Vol32, Oct,2002 p306P311
: Human securin interacts with p53 and modulates p53-mediated transcriptional
: activity and apoptosis.
: The first report show the relevance between human securin and p53.
: The gene PTTG1 is considered human securin gene which can inhibit
: sister-chromatid separation in vertebrates, thus may contribute to cell-cycle
: and tumorigenesis. The authors used phage display to identify the interaction
: between hPTTG1 and p53, and they carried out a series of functional a
1. The experiment they used to show securing binding of P53 affects ability of
P53 to bind DNA, I think it is a long shot to have that conclusion, there are
plenty of other alternative explanations. However, their in vivo experiments
are very convincing.
2. Can anyone tell me how many AA can phage display vectors successfully
express?
A recent paper by ES. Lander and TR. Golub in nature genetics (Jan 2003) “A
molecular signature of metastasis in primary solid tumors”
【在 c******a 的大作中提到】
: Nature Genetics Vol32, Oct,2002 p306P311
: Human securin interacts with p53 and modulates p53-mediated transcriptional
: activity and apoptosis.
: The first report show the relevance between human securin and p53.
: The gene PTTG1 is considered human securin gene which can inhibit
: sister-chromatid separation in vertebrates, thus may contribute to cell-cycle
: and tumorigenesis. The authors used phage display to identify the interaction
: between hPTTG1 and p53, and they carried out a series of functional a
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