By ectopic expression of only 4 transcription factors, terminal differentiated somatic cells can be transformed to be iPS cells. My question is that if iPS cells or ES cells can be directly programmed to a specific somatic cell fate by a pool of lineage specific transcription factors without usually used stepwise protocols. If yes, could you please show me some of the references? If not, what do you think might be the problem?
【在 h*****G 的大作中提到】 : By ectopic expression of only 4 transcription factors, terminal : differentiated somatic cells can be transformed to be iPS cells. My question : is that if iPS cells or ES cells can be directly programmed to a specific : somatic cell fate by a pool of lineage specific transcription factors : without usually used stepwise protocols. If yes, could you please show me : some of the references? If not, what do you think might be the problem?
Thank you. Lineage reprogramming is definitely very promising. As mentioned in another post, it has been showed that fibroblast can be transformed to neuron with only 3 TFs. At the same time, direct programming from ES/iPS cells to somatic cells are few. And I was not be able to find any publications. So was wondering if someone can help me with some papers about direct programming from ES/iPS cells to somatic cells with TFs, not stepwise extracellular signals. Thanks.
These are good questions! I also thought about that. Theoretically, directional differentiation is easier than reprogramming, because the latter is not a natuarl process. There is no any reason that transcription factors should not force cells to differentiate into specific lineage, given the facts of iPS. I don't think any lab has achieve this, though.
question
【在 h*****G 的大作中提到】 : By ectopic expression of only 4 transcription factors, terminal : differentiated somatic cells can be transformed to be iPS cells. My question : is that if iPS cells or ES cells can be directly programmed to a specific : somatic cell fate by a pool of lineage specific transcription factors : without usually used stepwise protocols. If yes, could you please show me : some of the references? If not, what do you think might be the problem?