Arsenate也就是AsO4(3−)是phosphate analogue,也就是说对蛋白酶来讲,AsO4(3−)和PO4(3-)无区别,所以细菌的enzyme完全可以把它错当PO4(3-)使用,加入DNA和protein里,这个没有多大意义,你们还争论用不用分析化学鉴定,没意思 最主要的是As妨碍普通细胞的呼吸oxidative phosphorylation,普通细胞没法在As下生存,不可能繁殖 但是这种几年前就被发现了的细胞有酶可以中和As,还可以靠As呼吸, 所以可以靠As生长,所以在用As替换P的环境下繁殖,就丝毫不足为奇了 所以更有意义的发现不是As替代P, 而是细菌可以在As里繁殖。这是个老消息了,可怜NASA不要脸,又玩花样骗钱 早就说过了,NASA是个很可怜的机构,在资本主义社会中没有任何存在的意义,所以要向好莱坞学习,不停搞出新闻来,才可以吸引缴税人民的注意力,搞研究经费 http://www.microbemagazine.org/index.php/02-2010-home/1358-microbial-arsenic-metabolism-new-twists-on-an-old-poison Because arsenate is a phosphate analogue, it can enter bacterial cells via phosphate transport systems (Pst and Pit). Once inside, arsenate uncouples oxidative phosphorylation from energy production and also interferes with glycolysis by forming 1-arseno-3-phosphoglycerate in place of 1,3- bisphosphoglycerate. Arsenite enters cells at neutral pH via aqua- glyceroporins, which ordinarily transport glycerol molecules into cells, and binds to sulfhydryl groups of cysteine residues, inactivating the proteins that it modifies. Meanwhile, arsine gas binds to red blood cells, damaging membranes and causing hemolysis. High doses can cause respiratory failure and death, whereas low chronic exposures cause cardiovascular stress, liver disease, and cancers. Some microbes not only are resistant to arsenic, but actively metabolize it via methylation, demethylation, oxidation, and reduction reactions, using some of these steps to generate energy. Methylation reactions convert As(V) or As(III) into compounds such as monomethyl arsonate (MMA(V)), methylarsonite (MMA(III), dimethylarsinate (DMA(V)), dimethylarsinite (DMA( III)), and trimethylarsine oxide as well as several volatile arsines, including monomethylarsine, dimethylarsine, and trimethylarsine. Although many of the enzymes involved remain unknown, a methyl transferase, ArsM, from Rhodobacter sphaeroides confers resistance to arsenic and can generate trimethylarsine.
【在 c******n 的大作中提到】 : Arsenate也就是AsO4(3−)是phosphate analogue,也就是说对蛋白酶来讲,AsO4(3−)和PO4(3-)无区别,所以细菌的enzyme完全可以把它错当PO4(3-)使用,加入DNA和protein里,这个没有多大意义,你们还争论用不用分析化学鉴定,没意思 : 最主要的是As妨碍普通细胞的呼吸oxidative phosphorylation,普通细胞没法在As下生存,不可能繁殖 : 但是这种几年前就被发现了的细胞有酶可以中和As,还可以靠As呼吸, 所以可以靠As生长,所以在用As替换P的环境下繁殖,就丝毫不足为奇了 : 所以更有意义的发现不是As替代P, 而是细菌可以在As里繁殖。这是个老消息了,可怜NASA不要脸,又玩花样骗钱 : 早就说过了,NASA是个很可怜的机构,在资本主义社会中没有任何存在的意义,所以要向好莱坞学习,不停搞出新闻来,才可以吸引缴税人民的注意力,搞研究经费 : http://www.microbemagazine.org/index.php/02-2010-home/1358-microbial-arsenic-metabolism-new-twists-on-an-old-poison : Because arsenate is a phosphate analogue, it can enter bacterial cells via : phosphate transport systems (Pst and Pit). Once inside, arsenate uncouples : oxidative phosphorylation from energy production and also interferes with : glycolysis by forming 1-arseno-3-phosphoglycerate in place of 1,3-
【在 c******n 的大作中提到】 : Arsenate也就是AsO4(3−)是phosphate analogue,也就是说对蛋白酶来讲,AsO4(3−)和PO4(3-)无区别,所以细菌的enzyme完全可以把它错当PO4(3-)使用,加入DNA和protein里,这个没有多大意义,你们还争论用不用分析化学鉴定,没意思 : 最主要的是As妨碍普通细胞的呼吸oxidative phosphorylation,普通细胞没法在As下生存,不可能繁殖 : 但是这种几年前就被发现了的细胞有酶可以中和As,还可以靠As呼吸, 所以可以靠As生长,所以在用As替换P的环境下繁殖,就丝毫不足为奇了 : 所以更有意义的发现不是As替代P, 而是细菌可以在As里繁殖。这是个老消息了,可怜NASA不要脸,又玩花样骗钱 : 早就说过了,NASA是个很可怜的机构,在资本主义社会中没有任何存在的意义,所以要向好莱坞学习,不停搞出新闻来,才可以吸引缴税人民的注意力,搞研究经费 : http://www.microbemagazine.org/index.php/02-2010-home/1358-microbial-arsenic-metabolism-new-twists-on-an-old-poison : Because arsenate is a phosphate analogue, it can enter bacterial cells via : phosphate transport systems (Pst and Pit). Once inside, arsenate uncouples : oxidative phosphorylation from energy production and also interferes with : glycolysis by forming 1-arseno-3-phosphoglycerate in place of 1,3-
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AsO4(3−)和 PO4(3-)无区别,所以细菌的enzyme完全可以把它错当PO4(3-)使用,加入DNA和 protein 里,这个没有多大意义,你们还争论用不用分析化学鉴定,没意思 下生 存,不可能繁殖 As生长,所以 在用As替换P的环境下繁殖,就丝毫不足为奇了 怜NASA不要 脸,又玩花样骗钱 要向好莱坞 学习,不停搞出新闻来,才可以吸引缴税人民的注意力,搞研究经费 arsenic-metabolism-new-twists-on-an-old-poison via uncouples with
【在 c******n 的大作中提到】 : Arsenate也就是AsO4(3−)是phosphate analogue,也就是说对蛋白酶来讲,AsO4(3−)和PO4(3-)无区别,所以细菌的enzyme完全可以把它错当PO4(3-)使用,加入DNA和protein里,这个没有多大意义,你们还争论用不用分析化学鉴定,没意思 : 最主要的是As妨碍普通细胞的呼吸oxidative phosphorylation,普通细胞没法在As下生存,不可能繁殖 : 但是这种几年前就被发现了的细胞有酶可以中和As,还可以靠As呼吸, 所以可以靠As生长,所以在用As替换P的环境下繁殖,就丝毫不足为奇了 : 所以更有意义的发现不是As替代P, 而是细菌可以在As里繁殖。这是个老消息了,可怜NASA不要脸,又玩花样骗钱 : 早就说过了,NASA是个很可怜的机构,在资本主义社会中没有任何存在的意义,所以要向好莱坞学习,不停搞出新闻来,才可以吸引缴税人民的注意力,搞研究经费 : http://www.microbemagazine.org/index.php/02-2010-home/1358-microbial-arsenic-metabolism-new-twists-on-an-old-poison : Because arsenate is a phosphate analogue, it can enter bacterial cells via : phosphate transport systems (Pst and Pit). Once inside, arsenate uncouples : oxidative phosphorylation from energy production and also interferes with : glycolysis by forming 1-arseno-3-phosphoglycerate in place of 1,3-