【在 s******e 的大作中提到】 : Strong recommendation! : This is the only book I wanna follow now. Even sometimes the author's taste : seems weird.
S*M
12 楼
重复不出来只是个说法而已 说不定人家已经有了造假的smoking gun了 但是说重复不出来总比说那哥们造假好听吧 edit: 原文也提了,不光是重复不出来的问题 有原始数据和发表的数据不吻合,这个很有可能就是smoking gun了 due to the inability “to reproduce the reported findings” and “inconsistencies between some of the figures and data published in the paper and the original data,” according to the retraction.
I think you are right. But it is hard to differentiate whether the data are not real or it is the people themselves who can't repeat the data, when the data can't be repeated in a lab. It is hard to tell. This is also a big topic for PIs who want to run a lab and do sciences. Also I can tell you have good technique in research. Most of time, not everyone does his job as great as you do. And this makes thing more complicated and I guess, it is what we call "limitation".
Since we are talking about reproducibility...I agree that you are right in general...there are clearly exceptions...besides what LZ and some already pointed out, there are also reproducible junk...because people try to fit data...or "some visionary guys" basically have a hypothesis which is likely right and then fit data..it is also a way bull lab screw small labs with their sloppy but happen to be right data/conclusions cause they could get through the reviewing process...
shall be but really hard to say with today's practice...Many big labs, the boss could be completely in dark if the postdoc/grad want to fake data... That said, lab culture does have a play there too...
During efforts to replicate and extend this work, we have been unable to reproduce the reported findings. Moreover, we have found inconsistencies between some of the figures and data published in the paper and the original data. We have therefore lost confidence in the reported conclusions. http://www.nature.com/nature/journal/v452/n7183/full/nature06819.html Nature 452, 120 (6 March 2008) | doi:10.1038/nature06819 Genetic tracing reveals a stereotyped sensory map in the olfactory cortex Zhihua Zou, Lisa F. Horowitz, Jean-Pierre Montmayeur, Scott Snapper & Linda B. Buck Nature 414, 173–179 (2001)
x*g
41 楼
如果一定要加一个时间,估计是一万年。。。
x*g
42 楼
likely 完全不知所云
【在 n********k 的大作中提到】 : Since we are talking about reproducibility...I agree that you are right in : general...there are clearly exceptions...besides what LZ and some already : pointed out, there are also reproducible junk...because people try to fit : data...or "some visionary guys" basically have a hypothesis which is likely : right and then fit data..it is also a way bull lab screw small labs with : their sloppy but happen to be right data/conclusions cause they could get : through the reviewing process...
"Moreover, we have found inconsistencies between some of the figures and data published in the paper and the original data. We have therefore lost confidence in the reported conclusions." She is saying that the PUBLISHED data != original data, implying that those papers are fabrication, and/or at least manipulations of the raw data. It's completely different from the issue of reproduction, since there were NEVER the 1st set results at all. How could you reproduce something that never exist in the 1st place?
exactly; 纯粹伪造! 伪造的==>不能重复 that's completely different from real results, but difficult to reproduce due to technical issues. since the PI is supposed the top expert in the field, if she can't even reproduce the same results in her lab; and found out the figures are different from the raw data, what can you say?!
【在 g*********d 的大作中提到】 : exactly; : 纯粹伪造! : 伪造的==>不能重复 : that's completely different from real results, : but difficult to reproduce due to technical issues. : since the PI is supposed the top expert : in the field, if she can't even reproduce : the same results in her lab; : and found out the figures are different : from the raw data, what can you say?!
好像各位看客都更观注于本人的研究而不是本帖所要讨论的核心问题,这个问题是 Science is not by science but by power! 就像People's Republic of China is not by People一样。 顺便说一下,本人做 的东西并不是特别特别难,只是大多数实验室(包括那些常在CNS上灌水的)都比较难以做成而已,但并不是不可重复。本领域目前在CNS上灌水很厉害的一个实验室的头在几年前的一个大会的注册日上见到我的结果后相当的吃惊(很明显他们已经尝试过但没成功),拉着本人仔细询问了一堆的tips后异常兴奋,连连说来开这个会值得了。
not by People一样。 CNS上灌水的)都比较难以做成而已,但并不是不可重复。本领域目前在CNS上灌水很厉 害的一个实验室的头在几年前的一个大会的注册日上见到我的结果后相当的吃惊(很明 显他们已经尝试过但没成功),拉着本人仔细询问了一堆的tips后异常兴奋,连连说来 开这个会值得了。
【在 F*Q 的大作中提到】 : 好像各位看客都更观注于本人的研究而不是本帖所要讨论的核心问题,这个问题是 : Science is not by science but by power! 就像People's Republic of China is not by People一样。 : 顺便说一下,本人做 的东西并不是特别特别难,只是大多数实验室(包括那些常在CNS上灌水的)都比较难以做成而已,但并不是不可重复。本领域目前在CNS上灌水很厉害的一个实验室的头在几年前的一个大会的注册日上见到我的结果后相当的吃惊(很明显他们已经尝试过但没成功),拉着本人仔细询问了一堆的tips后异常兴奋,连连说来开这个会值得了。