l*o
2 楼
不知道大家知不知道这家公司的这个系统。求各位大牛能够说说,教教我这个系统治疗
癌症靠铺嘛?
Chemosaturation of the liver represents an evolution from a highly invasive
open surgical procedure to a minimally invasive procedure for treating
patients with cancers in the liver.
In hepatic chemosaturation therapy, a percutaneous hepatic perfusion (PHP)
procedure delivers ultra-high doses of intra-arterial chemotherapy directly
into the isolated liver, saturating both the liver and the tumor cells. The
blood from the liver is drained through an isolation-aspiration catheter,
and then directed outside the body to proprietary filters, which reduce the
concentration of chemotherapeutic agent before this blood is returned to the
body.
The potential of chemosaturation therapy includes:
The ability to administer higher doses of chemotherapeutic agent to a
particular organ than could be delivered with traditional systemic-
intravenous methods
Significant reduction of systemic exposure to the higher dose levels
The potential to complement existing systemic treatments for primary disease
癌症靠铺嘛?
Chemosaturation of the liver represents an evolution from a highly invasive
open surgical procedure to a minimally invasive procedure for treating
patients with cancers in the liver.
In hepatic chemosaturation therapy, a percutaneous hepatic perfusion (PHP)
procedure delivers ultra-high doses of intra-arterial chemotherapy directly
into the isolated liver, saturating both the liver and the tumor cells. The
blood from the liver is drained through an isolation-aspiration catheter,
and then directed outside the body to proprietary filters, which reduce the
concentration of chemotherapeutic agent before this blood is returned to the
body.
The potential of chemosaturation therapy includes:
The ability to administer higher doses of chemotherapeutic agent to a
particular organ than could be delivered with traditional systemic-
intravenous methods
Significant reduction of systemic exposure to the higher dose levels
The potential to complement existing systemic treatments for primary disease
N*3
3 楼
预算多少?
i*g
4 楼
看了看,就是个介入治疗,
增加肝脏局部药物浓度(有助于杀伤肝肿瘤细胞),一般的疗法,药物是布满了全身,
副作用大
他这个疗法的特异是循环到体外,去除血液中药物分子。
疗效很难说,说不定能增加 比口服或静脉给药的5年生存率10~20%,或许也没什么增
效。这种办法出来,估计还没有取得足够临床数据。看上去有道理而已。
不过我认为对肝硬化的肝衰竭无效
增加肝脏局部药物浓度(有助于杀伤肝肿瘤细胞),一般的疗法,药物是布满了全身,
副作用大
他这个疗法的特异是循环到体外,去除血液中药物分子。
疗效很难说,说不定能增加 比口服或静脉给药的5年生存率10~20%,或许也没什么增
效。这种办法出来,估计还没有取得足够临床数据。看上去有道理而已。
不过我认为对肝硬化的肝衰竭无效
n*b
6 楼
栓塞治疗肝癌已经临床应用多年,尤其是在中国。Delcath没有比较或解释为什么
Chemosaturation有可能会有更多的优越性。
Chemosaturation有可能会有更多的优越性。
l*o
8 楼
谢谢两位的回答,包子已经奉上~
我的理解是这个系统还是比较有意思,针对器官局部和外部循环这个治疗方法还是比较
新的。
我觉得这样减少药物对其他器官和器官其他部位的伤害应该可以有助于治疗。但是也不
好说。
但是这个如果临床实验更多,可以得到更加针对性的结果。建立一个新的系统,有助于
以后药品的使用甚至开发。
不知道对不对
我的理解是这个系统还是比较有意思,针对器官局部和外部循环这个治疗方法还是比较
新的。
我觉得这样减少药物对其他器官和器官其他部位的伤害应该可以有助于治疗。但是也不
好说。
但是这个如果临床实验更多,可以得到更加针对性的结果。建立一个新的系统,有助于
以后药品的使用甚至开发。
不知道对不对
i*g
10 楼
这个其实是药物使用的医院改进版本(药物是药厂设计的)
但效果如何,要看3OS,5OS,
有时候构思和设想看着有道理
但很难说一定会有或者不会有预期的结果
熟悉生物体系的,实在很明白这个道理
但效果如何,要看3OS,5OS,
有时候构思和设想看着有道理
但很难说一定会有或者不会有预期的结果
熟悉生物体系的,实在很明白这个道理
l*o
12 楼
这公司在欧洲已经通过审查开始在德国铺货了,不知道FDA能不能过。美国是不是审查
更严?
更严?
z*e
13 楼
上周末Best Buy不是刚出来一个十三寸的$300 off,外加学生$50 off么?我好几个朋
友果断拿下了,以前就在纠结有点贵,呵呵。
友果断拿下了,以前就在纠结有点贵,呵呵。
g*r
14 楼
这种给药方法应该对水溶性大的药物有效, 而对水溶性较差,易与血清蛋白和血细胞结
合性强的药物会有较大的局限性.
合性强的药物会有较大的局限性.
l*1
16 楼
RE LZ
plus one review
Vergaro V et al. (2011)
Drug-loaded polyelectrolyte microcapsules for sustained targeting of cancer
cells.
Adv Drug Deliv Rev. 63: 847-64.
web link:
HTTP: //www.ncbi.nlm.nih.gov/pubmed/21620912
from one super bull in this field: Yuri M. Lvov
his team publications web link:
HTTP: //www2.latech.edu/~ylvov/publication.html
original hint was from one 2008 Book one Chapter contributed by YML
its full text link:
HTTP://nano.iauq.ac.ir/imagesMasterPage/Files/nano/file/nano%20
then just refer its pp33-41.
plus one review
Vergaro V et al. (2011)
Drug-loaded polyelectrolyte microcapsules for sustained targeting of cancer
cells.
Adv Drug Deliv Rev. 63: 847-64.
web link:
HTTP: //www.ncbi.nlm.nih.gov/pubmed/21620912
from one super bull in this field: Yuri M. Lvov
his team publications web link:
HTTP: //www2.latech.edu/~ylvov/publication.html
original hint was from one 2008 Book one Chapter contributed by YML
its full text link:
HTTP://nano.iauq.ac.ir/imagesMasterPage/Files/nano/file/nano%20
then just refer its pp33-41.
f*r
17 楼
多看看NANOMEDICINE吧
cancer
【在 l**********1 的大作中提到】
: RE LZ
: plus one review
: Vergaro V et al. (2011)
: Drug-loaded polyelectrolyte microcapsules for sustained targeting of cancer
: cells.
: Adv Drug Deliv Rev. 63: 847-64.
: web link:
: HTTP: //www.ncbi.nlm.nih.gov/pubmed/21620912
: from one super bull in this field: Yuri M. Lvov
: his team publications web link:
cancer
【在 l**********1 的大作中提到】
: RE LZ
: plus one review
: Vergaro V et al. (2011)
: Drug-loaded polyelectrolyte microcapsules for sustained targeting of cancer
: cells.
: Adv Drug Deliv Rev. 63: 847-64.
: web link:
: HTTP: //www.ncbi.nlm.nih.gov/pubmed/21620912
: from one super bull in this field: Yuri M. Lvov
: his team publications web link:
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