包子求paper# Biology - 生物学
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thanks a million
Nat Med. 2011 Nov 7;17(11):1359-70. doi: 10.1038/nm.2537.
Tumor angiogenesis: molecular pathways and therapeutic targets.
Weis SM, Cheresh DA.
Source
Department of Pathology and Moores University of California-San Diego Cancer
Center, University of California-San Diego, La Jolla, California, USA.
Abstract
As angiogenesis is essential for tumor growth and metastasis, controlling
tumor-associated angiogenesis is a promising tactic in limiting cancer
progression. The tumor microenvironment comprises numerous signaling
molecules and pathways that influence the angiogenic response. Understanding
how these components functionally interact as angiogenic stimuli or as
repressors and how mechanisms of resistance arise is required for the
identification of new therapeutic strategies. Achieving a durable and
efficient antiangiogenic response will require approaches to simultaneously
or sequentially target multiple aspects of the tumor microenvironment.
PMID: 22064426 [PubMed - indexed for MEDLINE]
thanks a million
Nat Med. 2011 Nov 7;17(11):1359-70. doi: 10.1038/nm.2537.
Tumor angiogenesis: molecular pathways and therapeutic targets.
Weis SM, Cheresh DA.
Source
Department of Pathology and Moores University of California-San Diego Cancer
Center, University of California-San Diego, La Jolla, California, USA.
Abstract
As angiogenesis is essential for tumor growth and metastasis, controlling
tumor-associated angiogenesis is a promising tactic in limiting cancer
progression. The tumor microenvironment comprises numerous signaling
molecules and pathways that influence the angiogenic response. Understanding
how these components functionally interact as angiogenic stimuli or as
repressors and how mechanisms of resistance arise is required for the
identification of new therapeutic strategies. Achieving a durable and
efficient antiangiogenic response will require approaches to simultaneously
or sequentially target multiple aspects of the tumor microenvironment.
PMID: 22064426 [PubMed - indexed for MEDLINE]
