本版有几个公认造假的。还是有一些新人不知道,还来问。 1 Pier Paolo Pandolfi (3P) 2 Michael Rosenfeld 3 Michael Karin 4 超级玛丽 凡是这几个实验室出来的paper,根本不用看,更不要信。 他们以前的WB都ps出来的,现在技术提高了,都是直接上样不同量的蛋白,blot actin ,说成是想要的蛋白。 统计图以前都是手动填数字,现在都是用软件生成随机数(这样算出来的噪音更逼真) 。
a*a
3 楼
5%
T*i
4 楼
超级玛丽的文章十年前就被质疑用PS了,还有说她的结果不能重复的,她现在也没事。
actin
【在 C********4 的大作中提到】 : 本版有几个公认造假的。还是有一些新人不知道,还来问。 : 1 Pier Paolo Pandolfi (3P) : 2 Michael Rosenfeld : 3 Michael Karin : 4 超级玛丽 : 凡是这几个实验室出来的paper,根本不用看,更不要信。 : 他们以前的WB都ps出来的,现在技术提高了,都是直接上样不同量的蛋白,blot actin : ,说成是想要的蛋白。 : 统计图以前都是手动填数字,现在都是用软件生成随机数(这样算出来的噪音更逼真) : 。
1. Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, Yuan J, Wang M, Chen D, Sun Y, Woodward W, Liu Y, Dean DC, Liang H, Hu Y, Ang KK, Hung MC, Chen J, Ma L. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol. In Press. 2. Chen D, Sun Y, Yuan Y, Han Z, Zhang P, Zhang J, You MJ, Teruya- Feldstein J, Wang M, Gupta S, Hung MC, Liang H, Ma L. miR-100 induces epithelial-mesenchymal transition but suppresses tumorigenesis, migration and invasion. PLoS Genet 10(2):e1004177, 2/2014. e-Pub 2/27/2014. PMCID: PMC3937226. 3. Chen D, Sun Y, Wei Y, Zhang P, Rezaeian AH, Teruya-Feldstein J, Gupta S, Liang H, Lin HK, Hung MC, Ma L. LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nat Med 18(10):1511-7, 9/2012. e-Pub 9/2012. PMID: 23001183. 4. Ma L, Reinhardt F, Pan E, Soutschek J, Bhat B, Marcusson EG, Teruya- Feldstein J, Bell GW, Weinberg RA. Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nat Biotechnol 28(4):341-7, 4/ 2010. e-Pub 3/2010. PMCID: PMC2852471. 5. Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D, Teruya-Feldstein J, Reinhardt F, Onder TT, Valastyan S, Westermann F, Speleman F, Vandesompele J, Weinberg RA. miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 12(3):247-56, 3/2010. e-Pub 2/2010. PMCID: PMC2845545. 6. Distefano G, Boca M, Rowe I, Wodarczyk C, Ma L, Piontek KB, Germino GG , Pandolfi PP, Boletta A. Polycystin-1 regulates extracellular signal- regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1. Mol Cell Biol 29(9) :2359-71, 2009. 7. Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, Egia A, Sasaki AT, Thomas G, Kozma SC, Papa A, Nardella C, Cantley LC, Baselga J, Pandolfi PP. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest 118(9):3065-74, 2008. 8. Ma L, Teruya-Feldstein J, Weinberg RA. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449(7163):682-688, 10/ 2007. PMID: 17898713. 9. Ma L, Teruya-Feldstein J, Bonner P, Bernardi R, Franz DN, Witte D, Cordon-Cardo C, Pandolfi PP. Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer. Cancer Research 67(15):7106-7112, 8/ 2007. PMID: 17671177. 10. Hernando E, Charytonowicz E, Dudas ME, Menendez S, Matushansky I, Mills J, Socci ND, Behrendt N, Ma L, Maki RG, Pandolfi PP, Cardon-Cardo C. The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas. Nature Medicine 13(6):748-753, 2007. 11. Ma L, Teruya-Feldstein J, Behrendt N, Chen Z, Noda T, Hino O, Cordon- Cardo C, Pandolfi PP. Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression. Genes & Development 19(15):1779-1786, 8/2005. PMCID: PMC1182340. 12. Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 121(2):179-193, 4/2005. PMID: 15851026. 13. Ruggero D, Montanaro L, Ma L, Xu W, Londei P, Cordon-Cardo C, Pandolfi PP. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nature Medicine 10(5):484-486, 5/ 2004. PMID: 15098029.
【在 l********n 的大作中提到】 : 1. Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, Yuan J, Wang M, : Chen D, Sun Y, Woodward W, Liu Y, Dean DC, Liang H, Hu Y, Ang KK, Hung MC, : Chen J, Ma L. ATM-mediated stabilization of ZEB1 promotes DNA damage : response and radioresistance through CHK1. Nat Cell Biol. In Press. : 2. Chen D, Sun Y, Yuan Y, Han Z, Zhang P, Zhang J, You MJ, Teruya- : Feldstein J, Wang M, Gupta S, Hung MC, Liang H, Ma L. miR-100 induces : epithelial-mesenchymal transition but suppresses tumorigenesis, migration : and invasion. PLoS Genet 10(2):e1004177, 2/2014. e-Pub 2/27/2014. PMCID: : PMC3937226. : 3. Chen D, Sun Y, Wei Y, Zhang P, Rezaeian AH, Teruya-Feldstein J, Gupta
c*u
27 楼
原来是她啊,就记着她薄后老板了,把一作给忘了。
l*y
28 楼
为什么要这么直白。
Gupta
【在 l********n 的大作中提到】 : 1. Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, Yuan J, Wang M, : Chen D, Sun Y, Woodward W, Liu Y, Dean DC, Liang H, Hu Y, Ang KK, Hung MC, : Chen J, Ma L. ATM-mediated stabilization of ZEB1 promotes DNA damage : response and radioresistance through CHK1. Nat Cell Biol. In Press. : 2. Chen D, Sun Y, Yuan Y, Han Z, Zhang P, Zhang J, You MJ, Teruya- : Feldstein J, Wang M, Gupta S, Hung MC, Liang H, Ma L. miR-100 induces : epithelial-mesenchymal transition but suppresses tumorigenesis, migration : and invasion. PLoS Genet 10(2):e1004177, 2/2014. e-Pub 2/27/2014. PMCID: : PMC3937226. : 3. Chen D, Sun Y, Wei Y, Zhang P, Rezaeian AH, Teruya-Feldstein J, Gupta
【在 l********n 的大作中提到】 : 1. Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, Yuan J, Wang M, : Chen D, Sun Y, Woodward W, Liu Y, Dean DC, Liang H, Hu Y, Ang KK, Hung MC, : Chen J, Ma L. ATM-mediated stabilization of ZEB1 promotes DNA damage : response and radioresistance through CHK1. Nat Cell Biol. In Press. : 2. Chen D, Sun Y, Yuan Y, Han Z, Zhang P, Zhang J, You MJ, Teruya- : Feldstein J, Wang M, Gupta S, Hung MC, Liang H, Ma L. miR-100 induces : epithelial-mesenchymal transition but suppresses tumorigenesis, migration : and invasion. PLoS Genet 10(2):e1004177, 2/2014. e-Pub 2/27/2014. PMCID: : PMC3937226. : 3. Chen D, Sun Y, Wei Y, Zhang P, Rezaeian AH, Teruya-Feldstein J, Gupta