丛乐反驳林帅亮邮件指控# Biology - 生物学
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http://mp.weixin.qq.com/s?__biz=MzIyNDA2NTI4Mg==&mid=2655409202&idx=1&sn=5d5e8ac0c386662a176c240a1b114bd1&scene=0#rd
注：丛乐否认了林帅亮自称是2011年10月至2012年6月之间实验室唯一一个做CRISPR课
题的人的说法，但是并没有对关键问题：即是否在看了Doudna的paper之后才实现了突
破做出明确回应。
原文标题：独家 | 关键人物反驳：“我很震惊……”（基因技术之争2）
撰文 | 丛乐（麻省理工学院-哈佛大学联合博德研究所）
● ● ●
这封邮件（编者注：系指美国专利与商标局本周公开的一封张锋实验室的前成员林帅亮
发给加州大学伯克利分校的分子生物学家詹妮弗·杜德娜的一封求职信，标题是：“博
德研究所的CRISPR专利以及申请贵实验室的职位”。详请参阅《知识分子》此前报道）
对我博士期间在张锋老师实验室中针对CRISPR基因编辑工作的描述与事实完全不符。我
很震惊林帅亮会做出这样的错误描述。我和张锋老师在2011年初开始开发CRISPR在哺乳
动物细胞中的应用并获得数据支持这个系统可以用来进行基因编辑。他在2011年10月作
为访问学生来实验室进行轮转。他来访期间，我们实验室成员在继续开发CRISPR技术，
作为他轮转研究的一部分他也参与了其中部分工作。访问期间我和张锋老师付出时间传
授他我们所掌握的实验技术并在科研方面对他进行指导，实验室CRISPR课题组成员一起
提供他作为轮转学生被张锋老师安排完成的实验所需要的帮助和实验材料。这段历史和
相关记录都很清楚，我希望确保你（编者注：指《知识分子》撰稿人）看到了Broad
Institute（博德研究所）对这一情况的回应，其中提供了几项关键证据，链接是：
https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/
journalists-statement-and-background-crispr-patent-interfer
英文版
Statement
I strongly disagree with the statements in the email as the description of
my work in Dr. Feng Zhang's lab is entirely incorrect. I am surprised he
would make such misstatements. Dr. Feng Zhang and I started working on
CRISPR in mammalian cells back in the beginning of 2011 and obtained
positive data to support the system can be harnessed to perform gene editing
. He was a visiting rotation student at the Broad from October 2011, and
members of the lab continued to work on CRISPR while he was asked to
participate as part of his rotation. During his time in the Zhang lab, Feng
and I spent time teaching him how to perform experiments, providing guidance
to him, and all lab members on the CRISPR team provided materials for him
to use in experiments he was asked to run by Feng as a rotation student. The
history and related documents are clear, and I wanted to be sure you had a
copy of the Broad Institute's response to this issue, which provides several
key evidence and is available here: https://www.broadinstitute.org/what-
broad/areas-focus/project-spotlight/journalists-statement-and-background-
crispr-patent-interfer
注：丛乐否认了林帅亮自称是2011年10月至2012年6月之间实验室唯一一个做CRISPR课
题的人的说法，但是并没有对关键问题：即是否在看了Doudna的paper之后才实现了突
破做出明确回应。
原文标题：独家 | 关键人物反驳：“我很震惊……”（基因技术之争2）
撰文 | 丛乐（麻省理工学院-哈佛大学联合博德研究所）
● ● ●
这封邮件（编者注：系指美国专利与商标局本周公开的一封张锋实验室的前成员林帅亮
发给加州大学伯克利分校的分子生物学家詹妮弗·杜德娜的一封求职信，标题是：“博
德研究所的CRISPR专利以及申请贵实验室的职位”。详请参阅《知识分子》此前报道）
对我博士期间在张锋老师实验室中针对CRISPR基因编辑工作的描述与事实完全不符。我
很震惊林帅亮会做出这样的错误描述。我和张锋老师在2011年初开始开发CRISPR在哺乳
动物细胞中的应用并获得数据支持这个系统可以用来进行基因编辑。他在2011年10月作
为访问学生来实验室进行轮转。他来访期间，我们实验室成员在继续开发CRISPR技术，
作为他轮转研究的一部分他也参与了其中部分工作。访问期间我和张锋老师付出时间传
授他我们所掌握的实验技术并在科研方面对他进行指导，实验室CRISPR课题组成员一起
提供他作为轮转学生被张锋老师安排完成的实验所需要的帮助和实验材料。这段历史和
相关记录都很清楚，我希望确保你（编者注：指《知识分子》撰稿人）看到了Broad
Institute（博德研究所）对这一情况的回应，其中提供了几项关键证据，链接是：
https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/
journalists-statement-and-background-crispr-patent-interfer
英文版
Statement
I strongly disagree with the statements in the email as the description of
my work in Dr. Feng Zhang's lab is entirely incorrect. I am surprised he
would make such misstatements. Dr. Feng Zhang and I started working on
CRISPR in mammalian cells back in the beginning of 2011 and obtained
positive data to support the system can be harnessed to perform gene editing
. He was a visiting rotation student at the Broad from October 2011, and
members of the lab continued to work on CRISPR while he was asked to
participate as part of his rotation. During his time in the Zhang lab, Feng
and I spent time teaching him how to perform experiments, providing guidance
to him, and all lab members on the CRISPR team provided materials for him
to use in experiments he was asked to run by Feng as a rotation student. The
history and related documents are clear, and I wanted to be sure you had a
copy of the Broad Institute's response to this issue, which provides several
key evidence and is available here: https://www.broadinstitute.org/what-
broad/areas-focus/project-spotlight/journalists-statement-and-background-
crispr-patent-interfer
