【原创】数字也邪恶# Joke - 肚皮舞运动
s*y
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http://science.sciencemag.org/content/351/6280/1405.1.full
昨天刚刚在Science 登出来的内容,NIH 的领导以及各机构director 合写了一篇文章
,声明NIH一向支持基础研究从来没有变改过,并把CRISPR 技术的进展作为一个基础研
究成功的例子。说他们注意到了很多所里的基础研究项目明显的减少了。但是他们坚持
说这些减少是因为往那些所投的基础研究项目变少了。他们为了鼓励纯基础研究,准备
简化一些文档,不再强迫研究者们写他们的研究到底和public health 有什么直接关系
。
但是他们没有明说的一点是,投入基础研究的资金会不会改变。
以下是全文:
Basic science: Bedrock of progress
Almost 4 years ago, one of us (F.S.C.) wrote an Editorial (1) affirming the
continued importance of basic research to the National Institutes of Health
(NIH) mission. The Editorial emphasized that basic scientific discovery is
the engine that powers the biomedical enterprise, and NIH continues to spend
more than half its budget supporting basic research projects. This is
critical, because the private sector generally funds projects that yield a
more rapid return on investment.
Despite these assurances, some members of the community believe that NIH's
interest in basic science is flagging. For example, investigators have told
us that the requirement for a “Public Health Relevance” statement in every
NIH research grant application suggests that every project must relate
directly to a public health concern—that NIH places less value on projects
that cannot be expected to yield an immediate public health benefit. This is
simply not true. As we wrote in our Strategic Plan (2), we recognize that
many of the most important medical advances trace back to basic research
that had no explicit disease link. To address this concern, we have revised
our application instructions (3) so that the Public Health Relevance
statement reflects the NIH mission and our commitment to supporting a robust
, diverse research portfolio, including the pursuit of basic biological
knowledge.
"PHOTO: ©PHIL DEGGINGER/ALAMY STOCK PHOTO"
We are particularly concerned that misperceptions about NIH's priorities and
interests may be causing investigators to submit fewer basic research
applications. For example, the National Institute of Neurological Disorders
and Stroke (NINDS) noticed a gradual and significant decline in the number
of basic grants awarded between 1997 and 2012 (4). This decrease in awards
was not a consequence of peer review given that basic grant applications
actually did substantially better in review than applied research proposals.
Instead, the major driver of this decline was a decrease in the number of
fundamental basic research applications submitted.
The taxpayer investment in NIH has yielded spectacular returns from basic
science over the long term. These range from the discoveries of the low-
density lipoprotein receptor (5) and the development of CRISPR-associated
protein-9 nuclease (6, 7) to recent substantial advances in structural
biology through cryo-electron microscopy (8). For this track record of
success to continue, we must continue our vigorous support of the pursuit of
fundamental knowledge. All of NIH's senior leaders believe strongly that
progress toward these goals occurs most rapidly when investigators pursue
their passions, whether they lie in basic research or in applied, disease-
focused studies. By supporting a broad portfolio of basic, translational,
population, and clinical research, NIH will continue to lead the way toward
a healthier future.
昨天刚刚在Science 登出来的内容,NIH 的领导以及各机构director 合写了一篇文章
,声明NIH一向支持基础研究从来没有变改过,并把CRISPR 技术的进展作为一个基础研
究成功的例子。说他们注意到了很多所里的基础研究项目明显的减少了。但是他们坚持
说这些减少是因为往那些所投的基础研究项目变少了。他们为了鼓励纯基础研究,准备
简化一些文档,不再强迫研究者们写他们的研究到底和public health 有什么直接关系
。
但是他们没有明说的一点是,投入基础研究的资金会不会改变。
以下是全文:
Basic science: Bedrock of progress
Almost 4 years ago, one of us (F.S.C.) wrote an Editorial (1) affirming the
continued importance of basic research to the National Institutes of Health
(NIH) mission. The Editorial emphasized that basic scientific discovery is
the engine that powers the biomedical enterprise, and NIH continues to spend
more than half its budget supporting basic research projects. This is
critical, because the private sector generally funds projects that yield a
more rapid return on investment.
Despite these assurances, some members of the community believe that NIH's
interest in basic science is flagging. For example, investigators have told
us that the requirement for a “Public Health Relevance” statement in every
NIH research grant application suggests that every project must relate
directly to a public health concern—that NIH places less value on projects
that cannot be expected to yield an immediate public health benefit. This is
simply not true. As we wrote in our Strategic Plan (2), we recognize that
many of the most important medical advances trace back to basic research
that had no explicit disease link. To address this concern, we have revised
our application instructions (3) so that the Public Health Relevance
statement reflects the NIH mission and our commitment to supporting a robust
, diverse research portfolio, including the pursuit of basic biological
knowledge.
"PHOTO: ©PHIL DEGGINGER/ALAMY STOCK PHOTO"
We are particularly concerned that misperceptions about NIH's priorities and
interests may be causing investigators to submit fewer basic research
applications. For example, the National Institute of Neurological Disorders
and Stroke (NINDS) noticed a gradual and significant decline in the number
of basic grants awarded between 1997 and 2012 (4). This decrease in awards
was not a consequence of peer review given that basic grant applications
actually did substantially better in review than applied research proposals.
Instead, the major driver of this decline was a decrease in the number of
fundamental basic research applications submitted.
The taxpayer investment in NIH has yielded spectacular returns from basic
science over the long term. These range from the discoveries of the low-
density lipoprotein receptor (5) and the development of CRISPR-associated
protein-9 nuclease (6, 7) to recent substantial advances in structural
biology through cryo-electron microscopy (8). For this track record of
success to continue, we must continue our vigorous support of the pursuit of
fundamental knowledge. All of NIH's senior leaders believe strongly that
progress toward these goals occurs most rapidly when investigators pursue
their passions, whether they lie in basic research or in applied, disease-
focused studies. By supporting a broad portfolio of basic, translational,
population, and clinical research, NIH will continue to lead the way toward
a healthier future.